Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:A-kinase anchor protein SPHKAPSPHKAPHomo sapiens (Human)-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveliFunctioniAnchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1."Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.", , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SPHK1. "Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.", , , , ,
[] [] []Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH TYPE I REGULATORY SUBUNIT OF PKA, IDENTIFICATION BY MASS SPECTROMETRY. GO - Molecular functioniGO - Biological processiNames & TaxonomyiProtein namesiRecommended name:A-kinase anchor protein SPHKAPAlternative name(s):SPHK1-interactor and AKAP domain-containing proteinSphingosine kinase type 1-interacting proteinGene namesiName:Synonyms:KIAA1678, SKIPOrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi Componenti: Chromosome 2 Organism-specific databases
HGNCi SPHKAP. Subcellular locationi "Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.", , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SPHK1. "Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.", , , , ,
[] [] []Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH TYPE I REGULATORY SUBUNIT OF PKA, IDENTIFICATION BY MASS SPECTROMETRY. Note: Colocalizes with SPHK1 in the cytoplasm.GO - Cellular componentiKeywords - Cellular componentiPathology & BiotechiOrganism-specific databases
PharmGKBi Polymorphism and mutation databases
DMDMi PTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsChaini1700A-kinase anchor protein SPHKAPPRO_Amino acid modificationsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineKeywords - PTMiProteomic databases
PeptideAtlasi
PRIDEi PTM databases
PhosphoSitei ExpressioniTissue specificityiHighly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain."Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.", , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SPHK1. "Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.", , , , ,
[] [] []Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH TYPE I REGULATORY SUBUNIT OF PKA, IDENTIFICATION BY MASS SPECTROMETRY. Gene expression databases
Genevisiblei HS. Organism-specific databases
InteractioniSubunit structureiInteracts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the interaction greatly reduces SPHK1 activity."Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.", , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SPHK1. "Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.", , , , ,
[] [] []Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH TYPE I REGULATORY SUBUNIT OF PKA, IDENTIFICATION BY MASS SPECTROMETRY. Binary interactionsiWithEntry#Exp.IntActNotesSPHK14GO - Molecular functioniProtein-protein interaction databases
BioGridi 1 interaction.
IntActi 1 interaction.
STRINGi Structurei3D structure databases
ProteinModelPortali
MobiDBiFamily & DomainsiRegionFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsRegioni18PKA-RII subunit binding domainDomainiRII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.Sequence similaritiesiBelongs to the .Phylogenomic databases
eggNOGi Eukaryota.
InParanoidi
PhylomeDBi
TreeFami Family and domain databases
InterProi AKAP_110_C.
SPHK1-interactor_AKAP_110.
PANTHERi PTHR10226. 1 hit.
Pfami AKAP_110. 1 hit.
[]Sequences (2)iSequence statusi: Complete.This entry describes 2 isoformsi produced by alternative splicing.
(identifier: Q2M3C7-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MDGNSLLSVP SNLESSRMYD VLEPQQGRGC GSSGSGPGNS ITACKKVLRS
100NSLLESTDYW LQNQRMPCQI GFVEDKSENC ASVCFVNLDV NKDECSTEHL
150QQKLVNVSPD LPKLISSMNV QQPKENEIVV LSGLASGNLQ ADFEVSQCPW
200LPDICLVQCA RGNRPNSTNC IIFEINKFLI GLELVQERQL HLETNILKLE
250DDTNCSLSSI EEDFLTASEH LEEESEVDES RNDYENINVS ANVLESKQLK
300GATQVEWNCN KEKWLYALED KYINKYPTPL IKTERSPENL TKNTALQSLD
350PSAKPSQWKR EAVGNGRQAT HYYHSEAFKG QMEKSQALYI PKDAYFSMMD
400KDVPSACAVA EQRSNLNPGD HEDTRNALPP RQDGEVTTGK YATNLAESVL
450QDAFIRLSQS QSTLPQESAV SVSVGSSLLP SCYSTKDTVV SRSWNELPKI
500VVVQSPDGSD AAPQPGISSW PEMEVSVETS SILSGENSSR QPQSALEVAL
550ACAATVIGTI SSPQATERLK MEQVVSNFPP GSSGALQTQA PQGLKEPSIN
600EYSFPSALCG MTQVASAVAV CGLGEREEVT CSVAPSGSLP PAAEASEAMP
650PLCGLASMEL GKEAIAKGLL KEAALVLTRP NTYSSIGDFL DSMNRRIMET
700ASKSQTLCSE NVVRNELAHT LSNVILRHSI DEVHHKNMII DPNDNRHSSE
750ILDTLMESTN QLLLDVICFT FKKMSHIVRL GECPAVLSKE TIRRRETEPS
800CQPSDPGASQ AWTKATESSS SSPLSNSHNT SLVINNLVDG MYSKQDKGGV
850RPGLFKNPTL QSQLSRSHRV PDSSTATTSS KEIYLKGIAG EDTKSPHHSE
900NECRASSEGQ RSPTVSQSRS GSQEAEESIH PNTQEKYNCA TSRINEVQVN
950LSLLGDDLLL PAQSTLQTKH PDIYCITDFA EELADTVVSM ATEIAAICLD
1000NSSGKQPWFC AWKRGSEFLM TPNVPCRSLK RKKESQGSGT AVRKHKPPRL
1050SEIKRKTDEH PELKEKLMNR VVDESMNLED VPDSVNLFAN EVAAKIMNLT
1100EFSMVDGMWQ AQGYPRNRLL SGDRWSRLKA SSCESIPEED SEARAYVNSL
1150GLMSTLSQPV SRASSVSKQS SCESITDEFS RFMVNQMENE GRGFELLLDY
1200YAGKNASSIL NSAMQQACRK SDHLSVRPSC PSKQSSTESI TEEFYRYMLR
1250DIERDSRESA SSRRSSQDWT AGLLSPSLRS PVCHRQSSMP DSRSPCSRLT
1300VNVPIKANSL DGFAQNCPQD FLSVQPVSSA SSSGLCKSDS CLYRRGGTDH
1350ITNMLIHETW ASSIEALMRK NKIIVDDAEE ADTEPVSGGS PSQAEKCANR
1400LAASRMCSGP TLLVQESLDC PRKDSVTECK QPPVSSLSKT ASLTNHSPLD
1450SKKETSSCQD PVPINHKRRS LCSREVPLIQ IETDQREACA GEPEPFLSKS
1500SLLEEAEGHS NDKNIPDVVR GGDTAVSACQ IHSDSLDTRD VPEAEASTEA
1550RAPDEAPNPP SSSEESTGSW TQLANEEDNP DDTSSFLQLS ERSMSNGNSS
1600ATSSLGIMDL DIYQESMPSS PMINELVEEK KILKGQSEST EAPASGPPTG
1650TASPQRSLLV INFDLEPECP DAELRATLQW IAASELGIPT IYFKKSQENR
1700IEKFLDVVQL VHRKSWKVGD IFHAVVQYCK MHEEQKDGRL SLFDWLLELG 1,700186,456February 21, 2006 - v1Checksum:i3D49589CAC5A1BDEBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q2M3C7-2)
[]The sequence of this isoform differs from the canonical sequence as follows:&&&&&: Missing.&1,671183,414Checksum:iFB6CD08DE8CC4797BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence cautioniThe sequence
differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Experimental InfoFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsSequence conflicti1D & G in
(PubMed:).Sequence conflicti1L & P in
(PubMed:).Sequence conflicti1F & S in
(PubMed:).Sequence conflicti1P & L in
(PubMed:).Sequence conflicti1D & I in
(PubMed:).Natural variantFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsNatural varianti1.Corresponds to variant rs4283414 [
].VAR_039263Natural varianti1."The full-ORF clone resource of the German cDNA consortium.", , , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 1), VARIANTS GLU-617 AND GLN-847. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.", , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 2), VARIANTS GLU-617 AND GLN-847. Corresponds to variant rs3811514 [
].VAR_039264Natural varianti1."The full-ORF clone resource of the German cDNA consortium.", , , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 1), VARIANTS GLU-617 AND GLN-847. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.", , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 2), VARIANTS GLU-617 AND GLN-847. Corresponds to variant rs3811515 [
].VAR_039265Natural varianti1.Corresponds to variant rs3828161 [
].VAR_039266Natural varianti1.Corresponds to variant rs [
].VAR_059113Alternative sequenceFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsAlternative sequencei29Missing
in isoform . "The full-ORF clone resource of the German cDNA consortium.", , , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 1), VARIANTS GLU-617 AND GLN-847. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.", , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 2), VARIANTS GLU-617 AND GLN-847. VSP_031712Sequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: .
Different initiation. mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .
UniGenei Genome annotation databases
Ensembli; ; .
UCSCi human.
[]Keywords - Coding sequence diversityi, Cross-referencesiSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: .
Different initiation. mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .
UniGenei 3D structure databases
ProteinModelPortali
MobiDBiProtein-protein interaction databases
BioGridi 1 interaction.
IntActi 1 interaction.
STRINGi PTM databases
PhosphoSitei Polymorphism and mutation databases
DMDMi Proteomic databases
PeptideAtlasi
PRIDEi Protocols and materials databases
Structural Biology KnowledgebaseGenome annotation databases
Ensembli; ; .
UCSCi human.
[]Organism-specific databases
GeneCardsi
HGNCi SPHKAP.
MIMi gene.
GenAtlasiPhylogenomic databases
eggNOGi Eukaryota.
InParanoidi
PhylomeDBi
TreeFami Miscellaneous databases
GenomeRNAii
SOURCEiGene expression databases
Genevisiblei HS. Family and domain databases
InterProi AKAP_110_C.
SPHK1-interactor_AKAP_110.
PANTHERi PTHR10226. 1 hit.
Pfami AKAP_110. 1 hit.
ProtoNetiPublicationsi"The full-ORF clone resource of the German cDNA consortium.", , , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 1), VARIANTS GLU-617 AND GLN-847. Tissue: . "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: . "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.", , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
(ISOFORM 2), VARIANTS GLU-617 AND GLN-847. Tissue: . "Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.", , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SPHK1. "Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.", , , , ,
[] [] []Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH TYPE I REGULATORY SUBUNIT OF PKA, IDENTIFICATION BY MASS SPECTROMETRY. + MiscellaneousiKeywords - Technical termi, Documents
Human chromosome 2: entries, gene names and cross-references to MIM
List of human entries with polymorphisms or disease mutations
Index of human polymorphisms and disease mutations
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Index of protein domains and families
Similar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.spray是什么意思_spray的翻译_音标_读音_用法_例句_爱词霸在线词典
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i该生词本已经创建啦! i不可以出现中文，英文，数字之外的符号哒! i生词本名称长度不能大于24字符! i请填写生词本名称!No input file specified.请问SPCHP是什么材料?_百度知道
请问SPCHP是什么材料?
我有更好的答案
这材料牌号从哪儿摘录的、准确吗？完整？SPCC原是日本标准(JIS)的“一般用冷轧碳钢薄板及钢带”钢材名称
完整的，我想是不是SPC，加的HP是什么意思就不明白了！
完整吗？你把上下文和具体出处（该材料用在什么场合？这些可能对推断都有帮助）都介绍清楚，要不然你直接问出处，看他们怎么回答，你怎么就这么肯定你摘抄的这个材料拼写没有错误呢？（现实中出现类似错误的情况比比皆是，要么字母拼写多了或少了，要么字母干脆拼写错了！如果是在错误的道路上花那么多时间值吗？）
最终选择注入法为主要制备方法通过正交L&,93&&'4&表考察脂质体的处方，最终确定处方为SPCH5∶1，SPPDTT10∶1，SPCHP3∶0.5，无菌注射用水为分散介质 5 PDTT长循环肺靶向脂质体体内外分析方法的建立通过HPLC建立了快速准确测定PDTT和异烟肼的方法，处方中辅料和可能残留的溶剂不会对测定产生影响体内HPLC分析方法能够准确测定异烟肼和PDTT在动物血浆中的含量
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