Adenium obesum怎么缩写

来源：蜘蛛抓取(WebSpider) 时间：2011-10-21 19:35 标签： 英文缩写
人生若只如初见，于千万人中相识，在转身的那一刻，不期而遇，那种美好的感觉犹如春天绽放的花儿，那种温馨，那种自然，那种真诚，那种回忆，会一直弥留在你的生命中，该是一种何等的美妙境界！
读席慕容的《初相遇》：美丽的梦和美丽的诗一样，都是可遇不可求的，常常在最没能料到的时刻里出现。
我喜欢那样的梦，在梦里，一切都可以重新开始，一切都可以慢慢解释，心里甚至还能感觉到，所有被浪费的时光都能重回时的狂喜与感激。胸怀中满溢着幸福，只因你就在我眼前，对我微笑，一如当年。
我真喜欢那样的梦，明明知道你已为我跋涉千里，却又觉得芳草鲜美，落英缤纷。好像你我才初初相遇。
人生若只如初见，所有
路边的灯光下，
我看到了那双鞋，
来自天堂的红色，
永远藏在记忆的最深处，
惟有你我知晓。。。
该穿凉鞋的时候了，
火热的夏是否还在怀恋春的美好，
还是我总在幻想，
知道你累了倦了，
好想你靠在我的肩膀上，就像从前一样，
让我再次感觉那份美好。。。
亲爱的朋友：
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2011 Feb 21;9(4):1133-9. doi: 10.677g. Epub
2010 Dec 20.New hedgehog/GLI-signaling inhibitors from Adenium obesum.1, , , , , .1Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. marai@p.chiba-u.ac.jpAbstractThe aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors. We recently constructed a cell-based screening system to search for Hh/GLI signaling inhibitors from natural resources. Using our screening system, Adenium obesum was found to include Hh/GLI signaling inhibitors from our tropical plant extract libraries. Bioassay-guided fractionation of this plant extract led to the isolation of 17 cardiac glycosides (1-17), including 3 new compounds (4, 9, 16). These compounds showed strong inhibitory activities, especially the IC(50) of 17 is 0.11 μM. The inhibition of GLI-related protein expression with 3, 9, 11, 15 and 17 was observed in human pancreatic cancer cells (PANC1), which express Hh/GLI components aberrantly. The expressions of GLI-related proteins PTCH and BCL2 were clearly inhibited. These compounds also showed selective cytotoxicity against two cancer cell lines, with less effect against normal cells (C3H10T1/2). RT-PCT examinations showed that Ptch mRNA expression by 3, 11, 15 and 17 was inhibited.PMID:
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