Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:Protein tramtrack, beta isoformttkDrosophila melanogaster (Fruit fly)-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveliFunctioniBinds to a number of sites in the transcriptional regulatory region of ftz. Isoform beta is required to repress inappropriate segmentation gene transcription and repress genes incompatible with development of photoreceptor cell fates. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. Inhibits Trl-dependent activation of eve. May bind to the region AGGGC/TGG. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk. A second method of degradation exists that is phyl-independent, this is mediated by recognition of motifs in the C-terminus of ttk."The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern.", EMBO J. 9:207-216(1990)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. "Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack.", Development 117:45-58(1993)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. "Tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye.",
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. "The Drosophila transcription factor tramtrack (TTK) interacts with Trithorax-like (GAGA) and represses GAGA-mediated activation.", , , ,
[] [] []Cited for: FUNCTION, INTERACTION WITH TRL, HOMODIMERIZATION. "Two modes of degradation of the tramtrack transcription factors by Siah homologues.", , ,
[] [] []Cited for: FUNCTION, INTERACTION WITH PHYL. RegionsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsZinc fingeri24C2H2-type 1Zinc fingeri24C2H2-type 2GO - Molecular functioniGO - Biological processiKeywords - Biological processi, Keywords - Ligandi, , Names & TaxonomyiProtein namesiRecommended name:Protein tramtrack, beta isoformAlternative name(s):Repressor protein fushi tarazuTramtrack p69Gene namesiName:ttkSynonyms:FTZ-F2ORF Names:CG1856OrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi Componenti: Chromosome 3R Organism-specific databases
FlyBasei ttk. Subcellular locationiGO - Cellular componentiKeywords - Cellular componentiPTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsChaini643Protein tramtrack, beta isoformPRO_Proteomic databases
PRIDEi ExpressioniDevelopmental stageiExpressed both maternally and zygotically. Expressed in preblastoderm embryos, followed by complete decay upon formation of the cellular blastoderm when ftz striped expression is at its peak."The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern.", EMBO J. 9:207-216(1990)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. "Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack.", Development 117:45-58(1993)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Gene expression databases
ExpressionAtlasi differential.
Genevisiblei DM. InteractioniSubunit structureiCan form homodimers. Interacts with Trl in vivo via the BTB domain. Interacts with phyl."The Drosophila transcription factor tramtrack (TTK) interacts with Trithorax-like (GAGA) and represses GAGA-mediated activation.", , , ,
[] [] []Cited for: FUNCTION, INTERACTION WITH TRL, HOMODIMERIZATION. "Two modes of degradation of the tramtrack transcription factors by Siah homologues.", , ,
[] [] []Cited for: FUNCTION, INTERACTION WITH PHYL. Binary interactionsiWithEntry#Exp.IntActNotesMEP-16GO - Molecular functioniProtein-protein interaction databases
BioGridi 56 interactions.
IntActi 3 interactions.
STRINGi StructureiSecondary structure1643Legend: HelixTurnBeta strandFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsBeta strandi4Beta strandi3Turni3Beta strandi4Helixi11Beta strandi4Turni3Beta strandi3Helixi113D structure databases
Select the link destinations:PDBeiRCSB PDBiPDBji
EntryMethodResolution (&A)ChainPositionsPDBsumX-ray2.80A/D[]
ProteinModelPortali
SMRi Positions
MobiDBiMiscellaneous databases
EvolutionaryTracei Family & DomainsiDomains and RepeatsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsDomaini66BTBSequence similaritiesiContains 1 .Contains 2 s.Zinc fingerFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsZinc fingeri24C2H2-type 1Zinc fingeri24C2H2-type 2Keywords - Domaini, Phylogenomic databases
eggNOGi Eukaryota.
OMAi Family and domain databases
Gene3Di 2 hits.
InterProi BTB/POZ_dom.
SKP1/BTB/POZ.
Znf_C2H2-like.
Znf_C2H2/integrase_DNA-bd.
Pfami BTB. 1 hit.
SMARTi BTB. 1 hit.
ZnF_C2H2. 2 hits.
SUPFAMi SSF54695. 1 hit.
PROSITEi BTB. 1 hit.
ZINC_FINGER_C2H2_1. 2 hits.
ZINC_FINGER_C2H2_2. 2 hits.
[]Sequences (2)iSequence statusi: Complete.This entry describes 2 isoformsi produced by alternative splicing.
(identifier: P17789-1)
[] Also known as: p69, C, D, FThis isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MKMASQRFCL RWNNHQSNLL SVFDQLLHAE TFTDVTLAVE GQHLKAHKMV
100LSACSPYFNT LFVSHPEKHP IVILKDVPYS DMKSLLDFMY RGEVSVDQER
150LTAFLRVAES LRIKGLTEVN DDKPSPAAAA AGAGATGSES TATTPQLQRI
200QPYLVPQRNR SQAGGLLASA ANAGNTPTLP VQPSLLSSAL MPKRKRGRPR
250KLSGSSNGTG NDYDDFDREN MMNDSSDLGN GKMCNESYSG NDDGSDDNQP
300NAGHTDDLNE SRDSLPSKRS KNSKDHRVVS HHEDNSTSDG NDSDGEGLDT
350SYMEPQLMLD EYDEPVEFKY NPLTDNSSPT QDHTDGSHLN EQARQQAFLI
400AAQRKHQVET AAAAAASGIK LNIIGMAAGG AQVKSMVSIP KLTPIGKVNA
450ASTPLVSPAG SFSTATVKPR VQKRPKLGKQ NGDVKPAVFS SQEYLDIYNS
500NDGFKLKAAG LSGSTPNLSA GLGTPSVKTK LNLSSNVGEG EAEGSVRDYC
550TKEGEHTYRC KVCSRVYTHI SNFCRHYVTS HKRNVKVYPC PFCFKEFTRK
600DNMTAHVKII HKIENPSTAL ATVAAANLAG QPLGVSGAST PPPPDLSGQN
640 SNQSLPATSN ALSTSSSSST SSSSGSLGPL TTSAPPAPAA AAQ 64368,771May 2, 2002 - v2Checksum:i98DAEA1A5E97DC59BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: P42282-1)
[] Also known as: p88, A, EThe sequence of this isoform can be found in the external entry . Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.81388,383BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence cautioniThe sequence
differs from that shown. Reason: Erroneous initiation. The sequence
differs from that shown. Reason: Frameshift at positions . The sequence
differs from that shown. Reason: Erroneous initiation. Experimental InfoFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsSequence conflicti1T & M in
(PubMed:).Sequence conflicti1H & Q in
(PubMed:).Sequence conflicti1T & I in
(PubMed:).Sequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: .
Different initiation. mRNA. Translation: .
Different initiation. mRNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .
Frameshift.
UniGenei Genome annotation databases
EnsemblMetazoai; ; .
GeneIDi Keywords - Coding sequence diversityiCross-referencesiSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: .
Different initiation. mRNA. Translation: .
Different initiation. mRNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .
Frameshift.
UniGenei 3D structure databases
Select the link destinations:PDBeiRCSB PDBiPDBji
EntryMethodResolution (&A)ChainPositionsPDBsumX-ray2.80A/D[]
ProteinModelPortali
SMRi Positions
MobiDBiProtein-protein interaction databases
BioGridi 56 interactions.
IntActi 3 interactions.
STRINGi Proteomic databases
PRIDEi Protocols and materials databases
Structural Biology KnowledgebaseGenome annotation databases
EnsemblMetazoai; ; .
GeneIDi Organism-specific databases
FlyBasei ttk. Phylogenomic databases
eggNOGi Eukaryota.
OMAi Miscellaneous databases
EvolutionaryTracei
GenomeRNAii Gene expression databases
ExpressionAtlasi differential.
Genevisiblei DM. Family and domain databases
Gene3Di 2 hits.
InterProi BTB/POZ_dom.
SKP1/BTB/POZ.
Znf_C2H2-like.
Znf_C2H2/integrase_DNA-bd.
Pfami BTB. 1 hit.
SMARTi BTB. 1 hit.
ZnF_C2H2. 2 hits.
SUPFAMi SSF54695. 1 hit.
PROSITEi BTB. 1 hit.
ZINC_FINGER_C2H2_1. 2 hits.
ZINC_FINGER_C2H2_2. 2 hits.
ProtoNetiPublicationsi"The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern.", EMBO J. 9:207-216(1990)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: . "Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack.", Development 117:45-58(1993)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: . "Tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye.",
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. "The genome sequence of Drosophila melanogaster.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: . "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: . "A Drosophila full-length cDNA resource.", , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: . Tissue: . , , , , , , , , , Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: . Tissue: . "Sequence-specific DNA binding by a two zinc-finger peptide from the Drosophila melanogaster Tramtrack protein.", , ,
[] [] []Cited for: DNA-BINDING. "The Drosophila transcription factor tramtrack (TTK) interacts with Trithorax-like (GAGA) and represses GAGA-mediated activation.", , , ,
[] [] []Cited for: FUNCTION, INTERACTION WITH TRL, HOMODIMERIZATION. "Two modes of degradation of the tramtrack transcription factors by Siah homologues.", , ,
[] [] []Cited for: FUNCTION, INTERACTION WITH PHYL. "The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition.", , , ,
[] [] []Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF . +
Q9V9V3Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990Last sequence update: May 2, 2002Last modified: July 6, 2016This is version 162 of the entry and version 2 of the sequence.
[]Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programMiscellaneousiCautionIt is uncertain whether Met-1 or Met-3 is the initiator.Keywords - Technical termi, , Documents
Drosophila: entries, gene names and cross-references to FlyBase
Index of Protein Data Bank (PDB) cross-references
Index of protein domains and families
Similar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.中基奥迪恭迎您来店品鉴2011款奥迪TT
来源：经销商供稿
时间： 17:30
中基奥迪恭迎您来店品鉴2011款奥迪TT新奥迪TT--Roadster新奥迪TTSCoupe(现展厅展示车型) 车型指导价(万元)TTCoupe2.0TFSIquattro51.90TTRoadster2.0TFSI56.50TTSCoupe2.0TFSIquattro66.20TTSRoadster2.0TFSI70.80 中基奥迪城市展厅2011款TT已到店，有部分现车，欢迎来店品鉴！ 2011款奥迪TT全系共推出了4款车型，与日在中国大陆地区上市，售价区间为51.9-70.8万元。2011款奥迪TT与此前在中国大陆地区销售的09款奥迪TT车型相比最大的改变在于前部分车型的进气格栅增加了镀铬饰条，并且全系增加了LED日间行车灯。使整车前脸看着更有气势、更显活力。 车型主要亮点 动力配备上实现了全面进化,新奥迪TT比老款车型在加速性上有了大幅提升,新奥迪TTCoup和Roadster在从静止加速到100公里/小时分别仅需6.0秒和6.1秒，比老款车型均节约了0.4秒.高性能版本的新奥迪TTS上搭载的2.0TFSI发动机最大功率更是达到了惊人的200千瓦(272马力)。对油耗的控制上，新车型搭载一套可以在刹车和行驶过程中为电池蓄能的"能量回收系统"，使新奥迪TTCoup和Roadster的每百公里油耗仅为6.9升，而动力更强的新奥迪TTSCoup和Roadster的每百公里油耗也控制在8升以内。同时车身采用基于ASF技术的轻量化车身使得自重降低。 一汽-大众奥迪特许经销商： 宁波中基汽车销售服务有限公司 销售热线：6 服务热线：1 地址：宁波市鄞州区下应北路666号 中基奥迪城市会所 尊享热线：1 7 会所地址：宁波市江东区江东南路159号（锦地水岸一层）（责任编辑：谢庆忠）雷克萨斯GS 300推出限量版 限量销售140台
来源：北青网汽车
时间： 09:02
近日，LEXUS雷克萨斯向中国市场推出GS 300特别限量版DDGS 300辉煌版，限量销售140辆，市场售价为64.9万元。 据介绍，GS 300辉煌版动力没有任何变化，只是在外观及内饰上做了比较大的改进，使这款车更具运动个性化。比如钢琴黑色的前格栅、纯黑格调前大灯反射板搭配时尚灰色轮毂；明亮的深棕、深橙双色彩条贯穿车身前后；深棕、深橙双色点缀于车门内饰板、方向盘及扶手箱上，配以专业团队度身定制的同配色真皮座椅等等。 另外，为了强调运动，GS 300辉煌版配备了抓地力更好的18英寸合金轮毂及更宽的胎面。（责任编辑：谢庆忠）代办居住证要价2000？工商局曝典型消费投诉典型案例
来源： 时间： 06:17
广佛都市网讯& 在电器店买的燃气灶两度爆燃，人身财产怎保障？外地户籍的消费者来佛山购车，车行代办居住证服务费居然要两千？购买“纯天然”碧玺手链，发现竟是化学物料填充时怎么办？近日，佛山市工商局12315公布3个去年消费投诉典型案例，提醒消费者维护自身利益。
两度爆燃的燃气灶谁敢用
2014年10月，蔡先生在禅城区某家用电器店购买了一台价值290元的家用燃气灶。使用两个月，燃气灶就发生爆燃，幸运的是并未伤到人，蔡先生赶紧向商家反映情况。两个月后，商家给他换了一台同品牌的单头燃气灶。没想到的是，替换的燃气灶在2015年4月下旬再度发生爆燃现象。这一次，蔡先生向商家反映问题后，商家却不予理睬。
无奈的蔡先生致电12315热线投诉。接到投诉后，工商部门执法人员到该家用电器店核查，要求商家对有质量问题的燃气灶作下架处理，不得继续销售。后经调解，商家最终同意为蔡先生更换一台不锈钢面的双头燃气灶。
消费提醒
市民选购燃气灶时，应注意选购产品的气源应与实际使用的气源一致，同时应选购具有熄火保护装置的产品，避免购买“假针式”或所谓“风吹不灭”无真正熄火保护装置的产品；购买前最好试火，检查其功能、燃烧状态、火力调节、风门调节等功能是否正常可靠；最后，切记选择标识明确、规范、具备安装资质和良好售后服务的知名企业、知名品牌的产品。
代办居住证要两千服务费
2015年9月初，罗先生在南海区罗村某车行订购一辆汽车，并支付了5000元预付款。他与车行签订的汽车销售协议上，明确约定车行一并提供包上牌、汽车保险、三年内保养等服务项目。但罗先生去提车时却遇到问题，由于他是外籍户口，车行表示若要为汽车办理佛山牌照，则需加收2000元居住证代办费用，或者由罗先生自己办理居住证后再办理车辆登记。
罗先生认为双方已约定好“包上牌”的服务，临时加收代办居住证费用做法不合理，因此提出解除购车协议、退回预付款的要求。车行以罗先生单方面违约为由拒绝退款。双方协商不成，罗先生随后向工商局投诉。
工商部门调解认为，双方协议中并未对购车总价款中“牌证费”一项的内容进行明确，并因沟通不充分而引起纠纷。最终，车行和罗先生达成和解，车行扣去1500元作为调配车辆产生的损失弥补，退回3500元预付款。
消费提醒
建议消费者在购车前及时了解我市汽车上牌的规定，咨询自身是否符合上牌、贷款条件，并在办理居住证后再购车；最重要的是，要与销售商约定在购车协议中列明具体收费项目、提车日期、上牌期限等事项。
“纯天然”碧玺手链填充化学物
去年，马女士在禅城一家饰品店购买一条价值6000元的碧玺手链，商家承诺该手链为“纯天然”的碧玺材质。但玉石鉴定中心的检测结果却显示，该碧玺手链经过处理，天然包体，但内有化学物质填充。对此，马女士向商家提出退货退款处理，协商失败后，向工商局12315热线求助。
在调解过程中，商家解释为了改善玉石的外观，往往需要对玉石进行处理，这是行业内部通行的做法，因此只愿意为消费者更换其他款式的碧玺手链。后经多次协调，商家最终同意了马女士退货退款的要求。
消费提醒
消费者在选购珠宝玉石首饰时，首先要了解珠宝玉石的品种、成色、颜色、折射率等相关知识，要明白纯天然珠宝玉石会因色泽、净度、切工的不同而价值相差甚远，不要盲目相信商家所宣传的低价促销手段；购买价格较高的珠宝玉石时，要向商家索取购物凭证，要求在凭证上注明“纯天然”、“A货”等字样；购买后应尽快到有资质的珠宝玉石鉴定所鉴定，一旦发现问题及时维权。
制图/曾玉婷& 文/佛山日报见习记者唐格桢
（责任编辑：梁毅玲）韩国三名登山队员于喜马拉雅山失踪 韩方已放弃救援
来源：环球网
时间： 09:03
环球网记者张哲报道，据韩国国际广播电台11月1日报道，韩国三名登山队员10月18日在尼泊尔攀登喜马拉雅山安娜普纳峰的过程中，与地面失去联系。韩国方面虽然先后派出两支搜救队前去救援，但始终未能找到失踪者。目前，搜救队已停止救援工作。 报道称，韩国著名登山家朴英硕（音）当地时间10月18日下午随同另两名队员试图攻破安娜普纳顶峰，但是他们在海拔6500米高处和地面进行最后一次通话后，便与地面失去了联系。 报道指出，位于尼泊尔加德满都的搜救指挥部及韩国“大韩山岳联盟”都曾派搜救队前去救援，但是没能找到失踪者。指挥部方面已将停止救援的消息传达给了失踪者家属。失踪者的家属目前已经抵达尼泊尔，并在当地一所寺庙里与韩国救援人员一起举行了“慰灵祭”。 据悉，朴英硕去年在安娜普纳峰南段的同一地点曾进行过路线开拓，但当时遇到了暴雪天气，该计划没能成功。（责任编辑：小A）
