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Replicase polyprotein 1abrepBat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)-Annotation score: -Protein inferred from homologyiFunctioniThe replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.Manual assertion inferred from sequence similarity toiHost translation inhibitor nsp1: Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.Manual assertion inferred from sequence similarity toiNon-structural protein 2: May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.Manual assertion inferred from sequence similarity toiPapain-like proteinase: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.Manual assertion inferred from sequence similarity toiNon-structural protein 4: Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.Manual assertion inferred from sequence similarity toiProteinase 3CL-PRO: Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).Manual assertion according to rulesiManual assertion inferred from sequence similarity toiNon-structural protein 6: Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.Manual assertion inferred from sequence similarity toiNon-structural protein 7: Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Manual assertion inferred from sequence similarity toiNon-structural protein 8: Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Manual assertion inferred from sequence similarity toiNon-structural protein 9: May participate in viral replication by acting as a ssRNA-binding protein.Manual assertion inferred from sequence similarity toiNon-structural protein 10: Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.Manual assertion inferred from sequence similarity toiRNA-directed RNA polymerase: Responsible for replication and transcription of the viral RNA genome.Manual assertion inferred from sequence similarity toiHelicase: Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.Manual assertion inferred from sequence similarity toiGuanine-N7 methyltransferase: Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.Manual assertion inferred from sequence similarity toiUridylate-specific endoribonuclease: Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.Manual assertion inferred from sequence similarity toi2'-O-methyltransferase: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.Manual assertion inferred from sequence similarity toiMiscellaneousBat coronavirus 279/2005 is highly similar to SARS-CoV (SARS-like).Catalytic activityiNucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).Manual assertion according to rulesiATP + H2O = ADP + phosphate.TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).SitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthActive siteiFor PL-PRO activityManual assertion according to rulesi1Active siteiFor PL-PRO activityManual assertion according to rulesi1Active siteiFor 3CL-PRO activityManual assertion according to rulesi1Active siteiFor 3CL-PRO activityManual assertion according to rulesi1Metal bindingiZinc 1Manual assertion according to rulesi1Metal bindingiZinc 1Manual assertion according to rulesi1Metal bindingiZinc 2Manual assertion according to rulesi1Metal bindingiZinc 1Manual assertion according to rulesi1Metal bindingiZinc 1Manual assertion according to rulesi1Metal bindingiZinc 2Manual assertion according to rulesi1Metal bindingiZinc 2Manual assertion according to rulesi1Metal bindingiZinc 2Manual assertion according to rulesi1Metal bindingiZinc 3Manual assertion according to rulesi1Metal bindingiZinc 3Manual assertion according to rulesi1Metal bindingiZinc 3Manual assertion according to rulesi1Metal bindingiZinc 3Manual assertion according to rulesi1RegionsFeature keyPosition(s)DescriptionActionsGraphical viewLengthZinc fingeriC4-typeManual assertion according to rulesi 38Zinc fingeri 17Zinc fingeri 14Nucleotide bindingiATP8GO - Molecular functioniGO - Biological processiKeywordsiMolecular function, , , , , , , , , , , Biological process, , , , , , , , , , , , , , , Ligand, , , Protein family/group databasesMEROPSiNames & TaxonomyiProtein namesiRecommended name:Replicase polyprotein 1abShort name: pp1abAlternative name(s):ORF1ab polyproteinCleaved into the following 15 chains:Short name: nsp1Alternative name(s):Leader proteinShort name: nsp2Alternative name(s):p65 homolog (EC:, EC:)Short name: PL-PROAlternative name(s):Non-structural protein 3Short name: nsp3Short name: nsp4 (EC:)Short name: 3CL-PROShort name: 3CLpAlternative name(s):nsp5Short name: nsp6Short name: nsp7Short name: nsp8Short name: nsp9Short name: nsp10Alternative name(s):Growth factor-like peptideShort name: GFL (EC:)Short name: PolShort name: RdRpAlternative name(s):nsp12 (EC:, EC:)Short name: HelAlternative name(s):nsp13 (EC:, EC:)Short name: ExoNAlternative name(s):nsp14 (EC:)Alternative name(s):NendoUnsp15 (EC:)Alternative name(s):nsp16Gene namesiName:repORF Names:1a-1bOrganismiTaxonomic identifieri
[]Taxonomic lineagei >
Virus hosti [TaxID: ]Proteomesi Componenti: Genome Subcellular locationi : ;
Manual assertion inferred from sequence similarity toi : ; Note: Localizes in virally-induced cytoplasmic double-membrane vesicles.Manual assertion inferred from sequence similarity toi :
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). :
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). :
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). :
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). :
Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA. :
TopologyFeature keyPosition(s)DescriptionActionsGraphical viewLengthTransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 21TransmembraneiHelical 20TransmembraneiHelical 20TransmembraneiHelical 21TransmembraneiHelical 21GO - Cellular componentiKeywords - Cellular componenti, , PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_Host translation inhibitor nsp1Manual assertion inferred from sequence similarity toi 179ChainiPRO_Non-structural protein 2Manual assertion inferred from sequence similarity toi 639ChainiPRO_Papain-like proteinaseManual assertion inferred from sequence similarity toi 1928ChainiPRO_Non-structural protein 4Manual assertion inferred from sequence similarity toi 500ChainiPRO_3C-like proteinaseManual assertion inferred from sequence similarity toi 306ChainiPRO_Non-structural protein 6Manual assertion inferred from sequence similarity toi 290ChainiPRO_Non-structural protein 7Manual assertion inferred from sequence similarity toi 83ChainiPRO_Non-structural protein 8Manual assertion inferred from sequence similarity toi 198ChainiPRO_Non-structural protein 9Manual assertion inferred from sequence similarity toi 113ChainiPRO_Non-structural protein 10Manual assertion inferred from sequence similarity toi 139ChainiPRO_RNA-directed RNA polymeraseManual assertion inferred from sequence similarity toi 932ChainiPRO_HelicaseManual assertion inferred from sequence similarity toi 601ChainiPRO_Guanine-N7 methyltransferaseManual assertion inferred from sequence similarity toi 527ChainiPRO_Uridylate-specific endoribonucleaseManual assertion inferred from sequence similarity toi 346ChainiPRO_2'-O-methyltransferaseManual assertion inferred from sequence similarity toi 298Post-translational modificationiSpecific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).SitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthSiteiCleavage2SiteiC by PL-PRO2SiteiC by PL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2SiteiC by 3CL-PRO2Proteomic databasesPRIDEiInteractioniSubunit structureiNsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.Manual assertion inferred from sequence similarity toiStructurei3D structure databasesProteinModelPortaliSMRiModBaseiMobiDBiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)DescriptionActionsGraphical viewLengthDomainiMacroManual assertion according to rulesi 167DomainiPeptidase C16Manual assertion according to rulesi 265DomainiPeptidase C30Manual assertion according to rulesi 306DomainiRdRp catalyticManual assertion according to rulesi 163DomainiCV ZBDManual assertion according to rulesi 84Domaini(+)RNA virus helicase ATP-binding 182Domaini(+)RNA virus helicase C-terminal 170RegionFeature keyPosition(s)DescriptionActionsGraphical viewLengthRegioniHD1 280RegioniHD2 408RegioniHD3 213RegioniRNA-directed RNA polymerase 303Compositional biasFeature keyPosition(s)DescriptionActionsGraphical viewLengthCompositional biasiGlu-rich 70Compositional biasiPoly-Leu4Compositional biasiPoly-Cys4Compositional biasiCys-rich 26DomainiThe hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.Sequence similaritiesiBelongs to the .Zinc fingerFeature keyPosition(s)DescriptionActionsGraphical viewLengthZinc fingeriC4-typeManual assertion according to rulesi 38Zinc fingeri 17Zinc fingeri 14Keywords - Domaini, , , Phylogenomic databasesOrthoDBiFamily and domain databasesGene3Di, 1 hit, 1 hit, 1 hit, 1 hit, 1 hit, 1 hitInterProi (+)RNA_virus_helicase_core_dom Corona_NSP4_C Coronavirus_NSP16 CV_ZBD EndoU-like Macro_dom NAR_dom NSP1 NSP10_sf NSP11 NSP1_sf Nsp3_coronavir Nsp3_coronavir_sf Nsp3_PL2pro Nsp3_PL2pro_sf NSP4_C_sf NSP7 NSP7_sf NSP8 NSP8_sf NSP9 NSP9_sf P-loop_NTPase Peptidase_C30 Peptidase_C30/C16 Peptidase_S1_PA pp1a/1ab RNA-dir_pol_PSvirus RNA_pol_N_coronovir RNA_synth_NSP10_coronavirus SAM-dependent_MTases SARS-CoV_Nsp3_N Viral_proteasePfami Corona_NSP4_C, 1 hit Corona_RPol_N, 1 hit DUF3655, 1 hit Macro, 1 hit NAR, 1 hit Nsp1, 1 hit NSP10, 1 hit NSP11, 1 hit NSP13, 1 hit Nsp3_PL2pro, 1 hit nsp7, 1 hit nsp8, 1 hit nsp9, 1 hit Peptidase_C30, 1 hit SUD-M, 1 hit Viral_protease, 1 hitSMARTi A1pp, 1 hitSUPFAMi SSF hit SSF hit SSF hit SSF hit SSF hit SSF hit SSF hit SSF50494, 1 hit SSF52540, 1 hit SSF53335, 1 hitPROSITEi CV_ZBD, 1 hit M_PRO, 1 hit MACRO, 1 hit PEPTIDASE_C16, 1 hit PSRV_HELICASE, 1 hit RDRP_SSRNA_POS, 1 hitSequences (2)iSequence statusi: Complete.Sequence processingi: The displayed sequence is further processed into a mature form.This entry describes 2 isoformsi produced by ribosomal frameshifting.
(identifier: P0C6V9-1)
[] Also known as: pp1abThis isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MESLALGVSE KTHVQLSLPV LQVRDVLVRG FGDSVEEALA EAREHLKNGT
100CGLVELEKGV LPQLEQPYVF IKRSDAQGTN HGYKVVELVA ELDGIQYGRS
150GTTLGVLVPH VGETPVAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGVELG
200TDPIEDYEQN WNTKHGGGVL RELIRELNGG AFTRYVDNNF CGPDGYPLEC
250IKDLLARAGK SMCTLSEQLD YIESKRGVYC CREHEHEIVW FTERSEKSYE
300RQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI
350RSVYPVATPQ ECNDMHLSTL MKCNHCDEVS WQTCDFLKAT CEQCGTENLV
400CEGPTTCGYL PANAVVKMPC PACQDPEVGP EHSVADYHNH SNIETRLRKG
450GRTKCFGGCV FAYVGCYNKR AYWVPRASAN IGASHTGITG DNVETLNEDL
500MEILNRDRVN INIVGDFHLN EEVAIILASF SASTCAFVDT VKGLDYKTFK
550DIVESCGNFK VTRGRAKKGA WNIGQEKSIL TPLYGFPSQA AGVIRSIFTR
600ALDTANHSIP DLQRAAITIL DGISEQSLRL IDAMVYTSDL LTNSVIVMAY
650VTGGLVQQIT QWLSNMLGTT VDKLKPVFTW VEAKLSAGIE FLRDAWEILK
700FLVTGVFDIV KGQIQVASDN LKECVKAFLD VLNKALEMCI DQVIIAGAKL
750RTLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLRAPKEVT FFEGDSHDTV
800FTSEEVVLKN GELEALETPV DSFTNGAVIG TPVCVNGLML LELKDKEQYC
850ALSPGLLATN NVFSLKGGAP VKGVTFGEDT VLEVQGYKNV KITFELDERV
900DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE
950WSVATFYLFD DAGEEKLSSR MYCSFYPPDE EEDCEEYEDE EEIPEETCEH
1000EYGTEDDYKG LPLEFGASTE IQQVDEEEEE DWLEEAIAAK PEPEPLPEEP
1050VNQFTGYLKL TDNVAIKCVD IVKEAQHAKP TVIVNAANVH LKHGGGVAGA
1100LNKATNGAMQ QESDDYIKKN GPLTVGGSCL LSGHNLAKKC MHVVGPNLNA
1150GEDVQLLKAA YANFNSQDVL LAPLLSAGIF GAKPLQSLKM CVETVRTQVY
1200FAVNDQDLYD HVVLGYLDSL KPKVETPTQE NLELKEQPAV ETLTQENLEL
1250EELPVIEKPV DVKFKARIEE VNTSLEETKF LTSRLLLFAD INGKLYQDSQ
1300NMLRGEDMFF LEKDAPYIVG DVISSGDITC VIIPAKKAGG TTEMLAKALK
1350KVPVSEYITT YPGQGCAGYT LEEAKTALRK CKSVFYVLPS KTPNDKEEIL
1400GTVSWNLREM LAHAEETRKL MLICMDVKAL MSTIHRRYKG IKVQEGIVDY
1450GVRFFFYTSK EPVASIITKL NLLNEPLVTM PIGYVTHGLN LEEAARCMRS
1500LKAPAVVSVS SPDAVTTYNG YLTSSSKTSE EHFIETVSLA GMYRDWSYSG
1550QRTELGVEFL KRGDKVVYHT VGSPIQFHLD GEVLLLDKLK SLLSLREVRT
1600IKVFTTVDNT NLHTQIVDMS MTYGQQFGPT YLDGADVTKI KPHAKHEGKT
1650FFVLPSDDTL RSEAFEYYHT LDESFLGRYM SALNHTKKWK FPQIGGLTSI
1700KWADNNCYLS SVLLALQQIE VKFNAPALQE AYYRARAGDA ANFCALILAY
1750SNRTVGELGD VRETMTHLLQ HANLESAKRV LNVVCKTCGQ KSTTLTGVEA
1800VMYMGTLSYE ELKTGVTIPC ICGRDATQYL VQQESSFVMM SAPPSEYTLQ
1850QGAFLCANEY TGSYQCGHYT HVTVKETLYR IDGAYLTKMS EYKGPVTDVF
1900YKEISYTTTI KPVSYKLDGV IYTEIQPKLD EYYKKDNAYY TEQPIDLVPT
1950QPLPNASFDN FKLTCSNTKF ADDLNQMTGF KKPASRELSV TFFPDLNGDV
2000VAIDYRHYSA SFKKGAKLLH KPIIWHINQT TNKTTYKPNT WCLRCLWSTK
2050PVETSNSFEV LEVEDTQGMD NLACESQTPT SEEVVENPTI QKEVIECDVK
2100TIEVVGNVIL KPSEEGVKVT QELGHEDLMA AYVEETSITI KKPNELSLAL
2150GLRTLATHGA AAINSVPWSK ILAYVKPFLG QAAVTTTNCI KRCVQRVFNN
2200YMPYVITLLF QLCTFTRSTN SRIRASLPTT IAKNSVKSVA KLCLDVCINY
2250VKSPKFSKLF TIAMWLLLLS ICLGSLIYVT AAFGVLLSNL GIPSYCDGVR
2300ESYVNSSNVT TMDFCEGSFL CSVCLNGLDS LDSYPALETI QVTISSYKLD
2350LTSLGLAAEW FLAYMLFTKF FYLLGLSAIM QVFFGYFASH FISNSWLMWF
2400IISIVQMAPV SAMVRMYIFF AFCYYVWKSY VHIMDGCTSS TCMMCYKRNR
2450ATRVECTTIV NGMKRSFYVY ANGGRGFCKA HNWNCLNCDT FCAGSTFISD
2500EVARDLSLQF KRPINPTDQS SYVVDSVAVK NGALHLYFDK AGQKTYERHP
2550LSHFVNLDNL RANNTKGSLP INVIVFDGKS KCDESAAKSA SVYYSQLMCQ
2600PILLLDQALV SDVGDSTEVS VKMFDAYVDT FSATFSVPME KLKALVATAH
2650SELAKGVALD GVLSTFVSAA RQGVVDTDVD TKDVIECLKL SHHSDLEVTG
2700DSCNNFMLTY NKVENMTPRD LGACIDCNAR HINAQVAKSH NVSLIWNVKD
2750YMSLSEQLRK QIRSAAKKNN IPFRLTCATT RQVVNAITTK ISLKGGKIVS
2800TWFKLMLKAT LLCVLAALFC YIIMPVHSLS VHDGYTNEII GYKAIQDGVT
2850RDIMATDDCF ANKHAGFDSW FSQRGGSYRN DKSCPVVAAI ITREIGFIVP
2900GLPGTVLRAI NGDFLHFLPR VFSAVGNICY TPSKLIEYSD FATSACVLAA
2950ECTIFKDAMG KPVPYCYDTN LLEGSISYSE LRPDTRYVLM DGSIIQFPNT
3000YLEGSVRVVT TFDAEYCRHG TCERSEAGVC LSTSGRWVLN NEHYRALPGV
3050FCGVDAMNLI ANIFTPLVQP VGALDVSASV VAGGIIAILV TCAAYYFMKF
3100RRAFGEYNHV VAANALLFLM SFTILCLAPA YSFLPGVYSI FYLYLTFYFT
3150NDVSFLAHLQ WFAMFSPIVP FWITAIYVFC ISLKHCHWFF NNYLRKRVMF
3200NGVTFSTFEE AALCTFLLNK EMYLKLRSET LLPLTQYNRY LALYNKYKYF
3250SGALDTTSYR EAACCHLAKA LNDFSNSGAD VLYQPPQTSI TSAVLQSGFR
3300KMAFPSGKVE GCMVQVTCGT TTLNGLWLDD TVYCPRHVIC TAEDMLNPNY
3350EDLLIRKSNH SFLVQAGNVQ LRVIGHSMQN CLLRLKVDTS NPKTPKYKFV
3400RIQPGQTFSV LACYNGSPSG VYQCAMRPNY TIKGSFLNGS CGSVGFNIDY
3450DCVSFCYMHH MELPTGVHAG TDLEGKFYGP FVDRQTAQAA GTDTTITLNV
3500LAWLYAAVIN GDRWFLNRFT TTLNDFNLVA MKYNYEPLTQ DHVDILGPLS
3550AQTGIAVLDM CAALKELLQN GMNGRTILGS TILEDEFTPF DVVRQCSGVT
3600FQGKFKKIVK GTHHWMLLTF LTSLLILVQS TQWSLFFFVY ENAFLPFTLG
3650IMAIAACAML LVKHKHAFLC LFLLPSLATV AYFNMVYMPA SWVMRIMTWL
3700ELADTSLSGY RLKDCVMYAS ALVLLVLMTA RTVYDDAARR VWTLMNVITL
3750VYKVYYGNSL DQAISMWALV ISVTSNYSGV VTTIMFLARA IVFVCVEYYP
3800LLFITGNTLQ CIMLVYCFLG YCCCCYFGLF CLLNRYFRLT LGVYDYLVST
3850QEFRYMNSQG LLPPKSSIDA FKLNIKLLGI GGKPCIKVAT VQSKMSDVKC
3900TSVVLLSVLQ QLRVESSSKL WAQCVQLHND ILLAKDTTEA FEKMVSLLSV
3950LLSMQGAVDI NKLCEEMLDN RATLQAIASE FSSLPSYAAY ATAQEAYEQA
4000VANGDSEVVL KKLKKSLNVA KSEFDRDAAM QRKLEKMADQ AMTQMYKQAR
4050SEDKRAKVTS AMQTMLFTML RKLDNDALNN IINNARDGCV PLNIIPLTTA
4100AKLMVVVPDY GTYKNTCDGN TFTYASALWE IQQVVDADSK IVQLSEINMD
4150NSQNLAWPLI VTALRANSAV KLQNNELSPV ALRQMSCAAG TTQTACTDDN
4200ALAYYNNSKG GRFVLALLSD HQDLKWARFP KSDGTGTIYT ELEPPCRFVT
4250DTPRGPKVKY LYFIKGLNNL NRGMVLGSLA ATVRLQAGNA TEVPANSAVL
4300SFCAFAVDPA KAYKDYLASG GQPITNCVKM LCTHTGTGQA ITVTPEANMD
4350QESFGGASCC LYCRCHIDHP NPKGFCDLKG KYVQIPATCA NDPVGFTLKN
4400TVCTVCGTWK GYGCSCDQLR EPMMQSADAS TFLNRVCGVS AARLTPCGTG
4450TSTDVVYRAF DIYNERVAGF AKFLKTNCCR FQEKDEEGNL LDSYFVVKRH
4500TMSNYQHEET IYNLVKECPA VAVHDFFKFR VDGDMVPHIS RQRLTKYTMA
4550DLVYALRHFD EGNCDTLKEI LVTYNCCDDD YFNKKDWYDF VENPDILRVY
4600ANLGERVRQA LLKTVQFCDA MRDAGIVGVL TLDNQDLNGN WYDFGDFVQV
4650APGCGVPIVD SYYSLLMPIL TLTKALAAES HMDADLAKPL IKWDLLKYDF
4700TEERLCLFDR YFKYWDQTYH PNCINCLDDR CILHCANFNV LFSTVFPPTS
4750FGPLVRKIFV DGVPFVVSTG YHFRELGVVH NQDVNLHSSR LSFKELLVYA
4800ADPAMHAASG NLLLDKRTTC FSVAALTNNV AFQTVKPGNF NKDFYDFAVS
4850KGFFKEGSSV ELKHFFFAQD GNAAISDYDY YRYNLPTMCD IRQLLFVVEV
4900VDKYFDCYDG GCINANQVIV NNLDKSAGFP FNKWGKARLY YDSMSYEDQD
4950VLFAYTKRNV IPTITQMNLK YAISAKNRAR TVAGVSICST MTNRQFHQKL
5000LKSIAATRGA TVVIGTSKFY GGWHNMLKTV YSDVETPHLM GWDYPKCDRA
5050MPNMLRIMAS LVLARKHSTC CNLSHRFYRL ANECAQVLSE MVMCGGSLYV
5100KPGGTSSGDA TTAYANSVFN ICQAVTANVN ALLSTDGNKI ADKYVRNLQH
5150RLYECLYRNR DVDHEFVDEF YAYLRKHFSM MILSDDAVVC YNSNYAAQGL
5200VASIKNFKAV HYYQNNVFMS EAKCWTETDL TKGPHEFCSQ HTMLVKQGDD
5250YVYLPYPDPS RILGAGCFVD DIVKTDGTLM IERFVSLAID AYPLTKHPNQ
5300EYADVFHLYL QYIRKLHDEL TGHMLDMYSV MLTNDNTSRY WEPEFYEAMY
5350TPHTVLQAVG ACVLCNSQTS LRCGACIRRP FLCCKCCYDH VISTSHKLVL
5400SVNPYVCNAP GCDVTDVTQL YLGGMSYYCK LHKPPISFPL CANGQVFGLY
5450KNTCVGSDNV TDFNAIATCD WTNAGDYILA NTCTERLKLF AAETLKATEE
5500TFKLSYGIAT VREVLSDREL HLSWEVGKPR PPLNRNYVFT GYRVTKNSKV
5550QIGEYTFEKG DYGDAVVYRG TTTYKLNVGD YFVLTSHTVM PLSAPTLVPQ
5600EHYVRITGLY PTLNISDEFS SNVANYQKVG MQKYSTLQGP PGTGKSHFAI
5650GLALYYPSAR IVYTACSHAA VDALCEKALK YLPIDKCSRI IPARARVECF
5700DKFKVNSTLE QYVFCTVNAL PETTADIVVF DEISMATNYD LSVVNARLRA
5750KHYVYIGDPA QLPAPRTLLT KGTLEPEYFN SVCRLMKTIG PDMFLGTCRR
5800CPAEIVDTVS ALVYDNKLKA HKEKSAQCFK MFYKGVITHD VSSAINRPQI
5850GVVREFLTRN PAWRKAVFIS PYNSQNAVAS KILGLPTQTV DSSQGSEYDY
5900VIFTQTTETA HSCNVNRFNV AITRAKIGIL CIMSDRDLYD KLQFTSLEVP
5950RRNVATLQAE NVTGLFKDCS KIITGLHPTQ APTHLSVDTK FKTEGLCVDI
6000PGIPKDMTYR RLISMMGFKM NYQVNGYPNM FITREEAIRH VRAWIGFDVE
6050GCHATRDAVG TNLPLQLGFS TGVNLVAVPT GYVDTENNTE FTRVNAKPPP
6100GDQFKHLIPL MYKGLPWNVV RIKIVQMLSD TLKGLSDRVV FVLWAHGFEL
6150TSMKYFVKIG PERTCCLCDR RATCFSTSSD TYACWNHSVG FDYVYNPFMI
6200DVQQWGFTGN LQSNHDQHCQ VHGNAHVASC DAIMTRCLAV HECFVKRVDW
6250SVEYPIIGDE LKINAACRKV QHMVVKSALL ADKFSVLHDI GNPKAIKCVP
6300QAEVDWKFYD AQPCSDKAYK IEELFYSYAT HHDKFTDGVC LFWNCNVDRY
6350PANAIVCRFD TRVLSNLNLP GCDGGSLYVN KHAFHTPAFD KSAFTYLKQL
6400PFFYYSDSPC ESHGKQVVSD IDYVPLKSAT CITRCNLGGA VCRRHANEYR
6450QYLDAYNMMI SAGFSLWIYK QFDTYNLWNT FTRLQSLENV AYNVVNKGHF
6500DGQIGEAPVS IINNAVYTKV DGNDVEIFEN KTTLPVNVAF ELWAKRNIKP
6550VPEIKILNNL GVDIAANTVI WDYKREAPAH VSTIGVCTMT DIAKKPTESA
6600CSSLTVLFDG RVEGQVDLFR NARNGVLITE GSVKGLTPSK GPAQASVNGV
6650TLIGESVKTQ FNYFKKVDGI IQQLPETYFT QSRDLEDFKP RSKMETDFLE
6700LAMDEFIQRY KLEGYAFEHI VYGDFSHGQL GGLHLMIGLA KRSQDSPLKL
6750EDFIPTDSTV KNYFITDAQT GSSKCVCSVI DLLLDDFVEI IKSQDLSVIS
6800KVVKVTIDYA EISFMLWCKD GHVETFYPKL QASQAWQPGV AMPNLYKMQR
6850MLLEKCDLQN YGENAVIPKG IMMNVAKYTQ LCQYLNTLTL AVPYNMRVIH
6900FGAGSDKGVA PGTAVLRQWL PTGALLVDSD LNDFVSDADS TLIGDCATVH
6950TANKWDLIIS DMYDPKTKHV TKENDSKEGF FTYLCGFIKQ KLALGGSVAV
7000KITEHSWNAD LYKLMGHFSW WTAFVTNVNA SSSEAFLIGV NYLGKLREQI
7050DGYTMHANYI FWRNTNPIQL SSYSLFDMSK FPLKLRGTAV MSLKENQIND
7070 MIYSLLENGR LIIRENNRVV VSSDILVNN
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.7,079791,654June 10, 2008 - v1Checksum:iCE92AE7AE019B902BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: P0C6F5-1)
[] Also known as: pp1a, ORF1a polyproteinThe sequence of this isoform can be found in the external entry . Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.Note: Produced by conventional translation.4,388487,709BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence cautioniThe sequence
differs from that shown. Reason: Erroneous initiation.Sequence databasesSelect the link destinations:EMBLiGenBankiDDBJi Genomic RNA Translation:
Different initiation.Keywords - Coding sequence diversityiSimilar proteinsi7073707370737073707370737073707370737073 Genomic RNA Translation:
Different initiation.3D structure databasesProteinModelPortaliSMRiModBaseiMobiDBiProtein family/group databasesMEROPSiProteomic databasesPRIDEiProtocols and materials databasesStructural Biology KnowledgebasePhylogenomic databasesOrthoDBiFamily and domain databasesGene3Di, 1 hit, 1 hit, 1 hit, 1 hit, 1 hit, 1 hitInterProi (+)RNA_virus_helicase_core_dom Corona_NSP4_C Coronavirus_NSP16 CV_ZBD EndoU-like Macro_dom NAR_dom NSP1 NSP10_sf NSP11 NSP1_sf Nsp3_coronavir Nsp3_coronavir_sf Nsp3_PL2pro Nsp3_PL2pro_sf NSP4_C_sf NSP7 NSP7_sf NSP8 NSP8_sf NSP9 NSP9_sf P-loop_NTPase Peptidase_C30 Peptidase_C30/C16 Peptidase_S1_PA pp1a/1ab RNA-dir_pol_PSvirus RNA_pol_N_coronovir RNA_synth_NSP10_coronavirus SAM-dependent_MTases SARS-CoV_Nsp3_N Viral_proteasePfami Corona_NSP4_C, 1 hit Corona_RPol_N, 1 hit DUF3655, 1 hit Macro, 1 hit NAR, 1 hit Nsp1, 1 hit NSP10, 1 hit NSP11, 1 hit NSP13, 1 hit Nsp3_PL2pro, 1 hit nsp7, 1 hit nsp8, 1 hit nsp9, 1 hit Peptidase_C30, 1 hit SUD-M, 1 hit Viral_protease, 1 hitSMARTi A1pp, 1 hitSUPFAMi SSF hit SSF hit SSF hit SSF hit SSF hit SSF hit SSF hit SSF50494, 1 hit SSF52540, 1 hit SSF53335, 1 hitPROSITEi CV_ZBD, 1 hit M_PRO, 1 hit MACRO, 1 hit PEPTIDASE_C16, 1 hit PSRV_HELICASE, 1 hit RDRP_SSRNA_POS, 1 hitProtoNetiMiscellaneousiKeywords - Technical termiDocumentsIndex of protein domains and familiesWe'd like to inform you that we have updated our
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