中国长江三峡集团公司->走进金沙江
&&&&大自然的鬼斧神工，造就了“万里长江第一湾”，造就了“虎跳峡”奇观，成就了金沙江那夺人心魄的壮美。&&&&金沙江是世界上少有的水能富集的河流。金沙江流经地区，天然落差达到5100米，水能资源理论蕴藏量4000多万千瓦，约占全国的17%。&&&&当年红军长征经过金沙江，毛主席写下了“金沙水拍云崖暖，大渡桥横铁索寒”这样豪迈的诗句。而今，把“高峡平湖”宏伟蓝图变为现实的三峡建设者，又向金沙江迈出了水电开发的步伐。中国长江三峡集团公司肩负“建设三峡，开发长江”的历史使命，将在金沙江上建设溪洛渡、向家坝、乌东德、白鹤滩等电站，仅这四个电站的总装机容量就达3850万千瓦。&&&&中国长江三峡集团公司2004年工作会议提出了加快金沙江水电开发步伐的目标。工作会议结束仅9天，中国长江三峡集团公司党组书记、总经理李永安，就率队赴金沙江考察。&&&&金沙江水电开发，不仅关系到总公司的发展战略，更是备受社会各界关注的热点。在2月8日召开的三峡工程新闻座谈会上，中央暨地方各大媒体采访的热点之一就是金沙江水电开发。为了让社会各界了解金沙江，中国长江三峡集团公司网站推出“走进金沙江”专题，并由一名特邀记者作随行报道。&&&&中国长江三峡集团公司网站欢迎您关注来自金沙江最前沿、最新的考察报道。
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版权所有& CopyRight , , All Rights Reserved第65期 流行病学5 4 冠心病风险因子
Effect of Correcting for Long-Term Variation in Major Coronary Heart Disease Risk Factors: Relative Hazard Estimation and Risk Prediction in the Atherosclerosis Risk in Communities StudyNina P. Paynter, PhDAffiliationsDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MDDivision of Preventive Medicine, Brigham and Women’s Hospital, Boston, MAAddress correspondence to: Nina P. Paynter, PhD, Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Ave, Boston, MA 02215. Tel.: +1 617 278 0798; Fax: +1 617 731 3843., Ciprian M. Crainiceanu, PhDAffiliationsDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, A. Richey Sharrett, MD, DrPHAffiliationsDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, Lloyd E. Chambless, PhDAffiliationsDepartment of Biostatistics, University of North Carolina School of Public Health, Chapel Hill, NC, Josef Coresh, MD, PhDAffiliationsDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MDDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MDReceived 29 April 2011; accepted 13 December 2011. published online 05 January 2012.Abstract Full Text PDFImages References Supplemental MaterialsPurposeTo examine the effect of correcting coronary heart disease (CHD) risk factors for long-term within-person variation on CHD risk.MethodsBy using 5533 men and 7301 women from the Atherosclerosis Risk in Communities (ARIC) study, we compared models incorporating risk factors measured at a single visit and models incorporating additional measurements for systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol taken 3 years before baseline.ResultsThe largest change away from null was observed for systolic blood pressure, ie, hazard ratio (HR) 1.38 to 1.69 (+81%) in women and HR 1.26 to 1.41 (+56%) in men. HRs also decreased for age (-32% in women, -9% in men), race (-67% in women), the presence of diabetes (-13% in men and women), and medication use for hypertension (-27% in women, -26% in men) and cholesterol (-97% in women, HR 1.06–0.93 in men). The area under the ROC curve did not improve significantly in men or women, whereas reclassification was only significant in women (net reclassification improvement 5.4%, p = 0.016).ConclusionsModeling long-term variation in CHD risk factors had a substantial impact on HR estimates, with new effect estimates further from the null for some risk factors and closer for others including age and medication use, but only improved risk classification in women.Key Words: Cardiovascular Models, Epidemiology, Heart Diseases, Risk Assessment, Risk Factors, StatisticsSelected Abbreviations and Acronyms: CHD, coronary heart disease, HDL, high-density lipoprotein, ARIC, Atherosclerosis Risk in Communities, AUC, area under the receiver operator characteristic curveTo access this article, please choose from the options below & Login Username:Password:Forgot Password? Remember me Register Login to an existing account or Register a new account.
Purchase this article for 31.50 USD (You must login/register to purchase this article) Online access for 24 hours. The PDF version can be downloaded as your permanent record.Subscribe to this title Get unlimited online access to this article and all other articles in this title 24/7 for one year. Claim access now For current subscribers with Society Membership or Account Number.Visit SciVerse ScienceDirect to see if you have access via your institution.
PII: S)00368-1doi:10.1016/j.annepidem.© 2012 Elsevier Inc. All rights reserved.温馨提示！由于新浪微博认证机制调整，您的新浪微博帐号绑定已过期，请重新绑定！&&|&&
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