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投Analytical Chemistry,一个大修，一个拒稿，编辑给拒了，还用申诉吗？
Dear Prof. Yu:
I am reporting on the above manuscript, which you recently submitted for consideration in Analytical Chemistry.
After a careful study of the manuscript and considering the reviewers' comments, I regret to inform you that I have decided against publication.&&The potential usefulness of your work is not in question.&&However, in light of the reviewers' evaluation and comments, I do not believe that publication is justified.&&I hope you will find the reviewers' specific comments helpful in planning future work.&&These comments are either included here or, if they were given in the form of a file, will appear at the bottom of the copy of this letter which will appear and be stored in your Author Center.
I appreciate the opportunity to have considered this contribution, and thank you for your interest in Analytical Chemistry.
Kind regards,
Reviewer: 1
Recommendation: Should not be published in Analytical Chemistry.
The authors reported a fluorescence turn-on method for the detection of Hg2+ based on the interaction of perylene probe and Au nanoparticles. In fact, the similar sensing strategies have been reported elsewhere, the paper itself lacks novelty. Moreover, the following questions should also be addressed.
1. In the introduction, the outstanding advantages of fluorescence assays compared with the reported methods are imprecise (Page 3, line 31-34).
2. In the manuscript, the authors state that the formation of the Au/Hg amalgam resulted in release of the probes. However, the probes should be added in the system after the formation of Au/Hg amalgam according to the Experimental Section and Scheme 1.
3. Some experiments and data should be supplemented. For example, the corresponding stability of the system, the corresponding concentrations should be noted in Figures for clearness, errors bars should be added in Fig. 5, and the experimental conditions for the detection of Hg2+ in lake water samples should be described in detail.
4. As for the selectivity, the authors only selected common divalent metal ions, other valent metal ions such as Ag+, Fe3+ should be performed.
5. The limit of detection (LOD) value of 5 nM was reported. How about the maximum residue limit of Hg2+ in drinking water as prescribed in Europe or USA? In addition, the authors should describe how the LOD was calculated.
6. For the real sample analysis, the sensors should be ultrasensitive, simple, rapid, and inexpensive. The chip sensor is a good choice, so the reported method could be further developed onto a chip sensor.
Additional Questions:
Significance: Moderate (not suitable for Analytical Chemistry)
Originality: Moderate (not suitable for Analytical Chemistry)
Broad Interest: Moderate (not suitable for Analytical Chemistry)
Technical Quality: Moderate (not suitable for Analytical Chemistry)
Are the conclusions adequately supported by the data?: Yes
Are the references appropriate and correct?: In Part
Is the English adequate?: In Part
Is the quality of the figures sufficient?: In Part
Are the data statistically significant with appropriate controls included?: In Part
Reviewer: 2
Recommendation: May eventually be publishable, but requires s as indicated.
This manuscript reports a novel fluorescence turn-on strategy based on Au nanoparticles and a perylene probe for the sensing of Hg2+ ions. Although the mechanism behind the synthesis &detection are carefully studied and the results are clearly presented, this work need major revise to satisfy the requirement of publication in Anal. Chem. Please take into account the following comments:
1. The author stated that the fluorescence turn-on strategy to detect Hg2+ ions. Form the meaning of “turn-on”, we think that the fluorescence of perylene probe is first quenched by Au NPs. Then with increasing of Hg2+ ions, the fluorescence of the sensor was becoming more and more strong. But in the actual detection, the sensing of Hg2+ was performed in two separate progresses. How about the results when the experiment was performed in the continuous detection progress?
2. In the study of selectivity of the sensor, the author selected a few ions only in (Ⅱ), how about the interference when ions (Ⅰ&Ⅲ) present? Such as Ag+?
Additional Questions:
Significance: High (suitable for Analytical Chemistry)
Originality: Moderate (not suitable for Analytical Chemistry)
Broad Interest: Moderate (not suitable for Analytical Chemistry)
Technical Quality: Moderate (not suitable for Analytical Chemistry)
Are the conclusions adequately supported by the data?: In Part
Are the references appropriate and correct?: Yes
Is the English adequate?: Yes
Is the quality of the figures sufficient?: In Part
Are the data statistically significant with appropriate controls included?: In Part
可能是人误解了
图片和表格我都是放在正文里面的，Electronic or PDF Journal Publishing Agreement 是老板提交的，我不懂
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analytical chemistry 非一般大修后接受的可能性多大？
analytical chemistry&& 四个审稿人 有一个直接据了 另二个大修 一个小修 编辑给的是非一般的大修？修改后接受的可能性有多大？这几天补实验补郁闷了 想放弃 可是analytical chemistry 一直是我最想发的杂志之一 所以还在坚持着～～
Thank you for submitting your manuscript for publication in the American Chemical Society journal Analytical Chemistry. It has been examined by expert reviewers whose reviews are enclosed. The reviewers have expressed serious reservations about this work that I do not believe could be addressed through a standard major revision. In light of the comments received, I am unable to accept the manuscript for publication in Analytical Chemistry.
However, if further experimentation, analysis, and revisions allow you to address the referees concerns in full we would be happy to consider a revised manuscript that included such data and analysis (assuming no related data is published in the interim). This revision should address the reviewers' comments and include a point-by-point response to the concerns.
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请教大家，关于投稿Analytical Chemistry 的问题
请各位大虾帮忙：
小女子实验马上告罄，接下来的事情就是写完文章然后投稿，我文章是边做边写的，差不多写完了，然后就面临一个很大的问题: 投稿投哪儿?
我的文章是采用一种荧光纳米粒子，研究了它两方面：
1、它本身光学性质：包括发光机理以及其它
2、它的应用： 为了证明我的NPs是可用的，我还利用它做了检测
但是我的文章是以1为主的，也就是说机理占主导，检测为辅
我的老板建议我投Analytical Chemistry& &但楼主认为 分析化学 比较注重检测，然而我的更侧重于机理，检测方面不是做的很全面，所以我想：
1、请大家了解AC投稿的帮我指点一下迷津
2、希望大家能推荐一下机理方面和AC处于同一档次的杂志还有那些？
太感谢大家了 :cat35::cat35::cat35::cat39::cat39::cat39::cat39::arm::hand::hand::hand::hand::arm::arm:
非常感谢您的应助&&听了您的指导感觉可以投AC试一把&&只要AC不止注重检测就好
AC 要低一些:P&&深知自己水平:D 确定投AC了 谢谢你:hand::hand::hand::arm::arm::arm:
学术必备与600万学术达人在线互动！
扫描下载送金币小木虫 --- 600万学术达人喜爱的学术科研平台
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投稿Analytical Chemistry，通讯作者可以有两个么？
RT，求教各位，本人打算投稿Analytical Chemistry，通讯作者可以有两个么？请举例。
由于我们单位没买数据库，我只能查到AC的主页，文章列表里也没看到通讯作者的信息:(
学术必备与600万学术达人在线互动！
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