杀毒后电脑超慢(22点) - 怎么办？ - 怎么治？
Andy 提问：
杀毒后电脑超慢(22点)
我今天用360杀毒查到了毒，杀掉了也重开机过了，但电脑还是好慢，怎么回事?怎么样才能让电脑变的像原来一样呢? 更多：
Pieter 回答：
Hi ,鬼漾但电脑还是好慢，怎么回事?先按Ctrl+Alt+Delete(打开工作管理员)先看看下面的&CPU使用率&%数越高
则效率越差
则效率越高接下来上面标签&处理程序&查看看是不是有无开启Foxy.exe
PPSAP.exePPSStream.exe等容易占有大量CPU使用率的程序若有
& 结束处理程序
&占用CPU的原因有很多大多是开启来的程序另外
也会占用CPU多扫几次毒不然就花钱送修
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235 high-probability publications.
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Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, ... ... Dorrestein PC, et al. Author Correction: Inflammation-induced IgA cells dismantle anti-liver cancer immunity. Nature. PMID
Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, . Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. Msystems. 3. PMID
Patin NV, Floros DJ, Hughes CC, Dorrestein PC, Jensen PR. The role of inter-species interactions in Salinispora specialized metabolism. Microbiology (Reading, England). PMID
McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. Msystems. 3. PMID
Knight R, Vrbanac A, Taylor BC, Aksenov A, Callewaert C, Debelius J, Gonzalez A, Kosciolek T, McCall LI, McDonald D, Melnik AV, Morton JT, Navas J, Quinn RA, Sanders JG, ... ... Dorrestein PC, et al. Best practices for analysing microbiomes. Nature Reviews. Microbiology. PMID
McCall LI, Tripathi A, Vargas F, Knight R, Dorrestein PC, Siqueira-Neto JL. Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome. Plos Neglected Tropical Diseases. 12: e0006344. PMID
Kapono CA, Morton JT, Bouslimani A, Melnik AV, Orlinsky K, Knaan TL, Garg N, Vázquez-Baeza Y, Protsyuk I, Janssen S, Zhu Q, Alexandrov T, Smarr L, Knight R, Dorrestein PC. Creating a 3D microbial and chemical snapshot of a human habitat. Scientific Reports. 8: 3669. PMID
Dorrestein PC, . Chemical signaling at the eukaryotic/prokaryotic interface. Chemical Society Reviews. PMID
Puri AW, , , , Liu D, Piel J, Dorrestein PC, Greenberg P, Lidstrom ME, Clardy J. Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. Journal of the American Chemical Society. PMID
Protsyuk I, Melnik AV, Nothias LF, Rappez L, Phapale P, Aksenov AA, Bouslimani A, Ryazanov S, Dorrestein PC, Alexandrov T. 3D molecular cartography using LC-MS facilitated by Optimus and 'ili software. Nature Protocols. 13: 134-154. PMID
Pla D, , Saviola AJ, Modahl CM, Sanz L, Pérez A, Juárez E, Frietze S, Dorrestein PC, Mackessy SP, Calvete JJ. Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam. Journal of Proteomics. 174: 71-84. PMID
Shalapour S, , Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, ... ... Dorrestein PC, et al. Erratum: Inflammation-induced IgA(+) cells dismantle anti-liver cancer immunity. Nature. PMID
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, ... ... Dorrestein PC, et al. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 551: 340-345. PMID
Scheubert K, Hufsky F, , Wang M, Nothias LF, Dührkop K, Bandeira N, Dorrestein PC, B?cker S. Significance estimation for large scale metabolomics annotations by spectral matching. Nature Communications. 8: 1494. PMID
Hartmann AC, , Quinn RA, Protsyuk I, Archer FI, Ransome E, Williams GJ, Bailey BA, Vermeij MJA, Alexandrov T, Dorrestein PC, Rohwer FL. Meta-mass shift chemical profiling of metabolomes from coral reefs. Proceedings of the National Academy of Sciences of the United States of America. PMID
Garg N, Wang M, Hyde E, da Silva RR, Melnik AV, Protsyuk I, Bouslimani A, Lim YW, Wong R, Humphrey G, Ackermann G, Spivey T, Brouha SS, Bandeira N, Lin GY, ... ... Dorrestein PC, et al. Three-Dimensional Microbiome and Metabolome Cartography of a Diseased Human Lung. Cell Host & Microbe. PMID
Vázquez-Baeza Y, Callewaert C, Debelius J, Hyde E, Marotz C, Morton JT, Swafford A, Vrbanac A, Dorrestein PC, Knight R. Impacts of the Human Gut Microbiome on Therapeutics. Annual Review of Pharmacology and Toxicology. PMID
McCall LI, Morton JT, Bernatchez JA, Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Analytical Chemistry. PMID
Ainsworth S, , Engmark M, Süssmuth RD, Whiteley G, Albulescu LO, Kazandjian TD, Wagstaff SC, Rowley P, Wüster W, Dorrestein PC, Arias AS, Gutiérrez JM, Harrison RA, Casewell NR, et al. The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms. Journal of Proteomics. PMID
Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, . Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. Journal of Natural Products. PMID
Edlund A, Garg N, Mohimani H, Gurevich A, He X, , Dorrestein PC, McLean JS. Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules. Msystems. 2. PMID
Boya P CA, Fernández-Marín H, Mejía LC, Spadafora C, Dorrestein PC, Gutiérrez M. Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants. Scientific Reports. 7: 5604. PMID
Hsu CC, , Gaasterland T, Meehan MJ, , Dorrestein PC. Top-Down Atmospheric Ionization Mass Spectrometry Microscopy Combined With Proteogenomics. Analytical Chemistry. PMID
Melnik AV, Dorrestein PC, da Silva RR, Hyde ER, Aksenov AA, Vargas F, Bouslimani A, Protsyuk I, , Tripathi A, Alexandrov T, Knight R. Coupling targeted and untargeted mass spectrometry for metabolome-microbiome-wide association studies of human fecal samples. Analytical Chemistry. PMID
Luzzatto Knaan T, Garg N, Wang M, Glukhov E, , Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, , Dorrestein PC. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 6. PMID
Kinnel RB, , Leao T, Moss N, , Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, . A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. Journal of Natural Products. PMID
Floros DJ, , Kapono CA, Melnik AV, Ling TJ, Knight R, Dorrestein PC. Mass Spectrometry Based Molecular 3D-Cartography of Plant Metabolites. Frontiers in Plant Science. 8: 429. PMID
Crüsemann M, , Larson CB, Melnik AV, Floros DJ, da Silva RR, Jensen PR, Dorrestein PC, . Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols. Journal of Natural Products. 80: 588-597. PMID
Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, , Kim JN, Lockhart A, Artis K, David G, ... ... Dorrestein PC, et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Science Translational Medicine. 9. PMID
Morton JT, Sanders J, Quinn RA, McDonald D, Gonzalez A, Vázquez-Baeza Y, Navas-Molina JA, Song SJ, Metcalf JL, Hyde ER, Lladser M, Dorrestein PC, Knight R. Balance Trees Reveal Microbial Niche Differentiation. Msystems. 2. PMID
Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, , ... ... Dorrestein PC, et al. Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nature Microbiology. 2: 17010. PMID
, , Dorrestein PC. From single cells to our planet-recent advances in using mass spectrometry for spatially resolved metabolomics. Current Opinion in Chemical Biology. 36: 24-31. PMID
Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, . Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. Journal of Natural Products. PMID
Floros DJ, Jensen PR, Dorrestein PC, Koyama N. A metabolomics guided exploration of marine natural product chemical space. Metabolomics : Official Journal of the Metabolomic Society. 12. PMID
Garg N, Zeng Y, Edlund A, Melnik AV, , Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, , Cichewicz RH, ... ... Dorrestein PC, et al. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. Msystems. 1. PMID
Nothias LF, Knight R, Dorrestein PC. Antibiotic discovery is a walk in the park. Proceedings of the National Academy of Sciences of the United States of America. PMID
Garg N, Luzzatto-Knaan T, Melnik AV, Caraballo-Rodríguez AM, Floros DJ, , Gregor R, Dorrestein PC, Phelan VV. Natural products as mediators of disease. Natural Product Reports. PMID
Bouslimani A, Melnik AV, Xu Z, Amir A, da Silva RR, Wang M, Bandeira N, Alexandrov T, Knight R, Dorrestein PC. Lifestyle chemistries from phones for individual profiling. Proceedings of the National Academy of Sciences of the United States of America. PMID
Quinn RA, Nothias LF, Vining O, Meehan M, , Dorrestein PC. Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy. Trends in Pharmacological Sciences. PMID
Wohlgemuth G, Mehta SS, Mejia RF, Neumann S, Pedrosa D, Pluskal T, Schymanski EL, Willighagen EL, Wilson M, Wishart DS, Arita M, Dorrestein PC, Bandeira N, Wang M, Schulze T, et al. SPLASH, a hashed identifier for mass spectra. Nature Biotechnology. 34: . PMID
Maansson M, Vynne NG, Klitgaard A, Nybo JL, Melchiorsen J, Nguyen DD, , Ziemert N, Dorrestein PC, Andersen MR, Gram L. An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria. Msystems. 1. PMID
Quinn RA, Navas-Molina JA, Hyde ER, Song SJ, Vázquez-Baeza Y, Humphrey G, Gaffney J, Minich JJ, Melnik AV, Herschend J, DeReus J, Durant A, Dutton RJ, Khosroheidari M, Green C, ... ... Dorrestein PC, et al. From Sample to Multi-Omics Conclusions in under 48 Hours. Msystems. 1. PMID
Mohimani H, Gurevich A, Mikheenko A, Garg N, Nothias LF, Ninomiya A, Takada K, Dorrestein PC, . Dereplication of peptidic natural products through database search of mass spectra. Nature Chemical Biology. PMID
Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, , ... ... Dorrestein PC, et al. Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nature Microbiology. 2: 16197. PMID
, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook VY, Garg N, Hoffner N, , Kapono CA, ... ... Dorrestein PC, et al. Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Analytical Chemistry. PMID
Wang M, Carver JJ, , , Garg N, , Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, , ... ... Dorrestein PC, et al. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology. 34: 828-837. PMID
, Quinn RA, Debelius J, Xu ZZ, Morton J, Garg N, Jansson JK, Dorrestein PC, Knight R. Microbiome-wide association studies link dynamic microbial consortia to disease. Nature. 535: 94-103. PMID
Miyamoto S, Hsu CC, Hamm G, Darshi M, Diamond-Stanic M, Declèves AE, Slater L, Pennathur S, Stauber J, Dorrestein PC, Sharma K. Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator. Ebiomedicine. 7: 121-134. PMID
Deveau A, Gross H, Palin B, Mehnaz S, Schnepf M, Leblond P, Dorrestein PC, Aigle B. Role of secondary metabolites in the interaction between Pseudomonas fluorescens and soil microorganisms under iron limited conditions. Fems Microbiology Ecology. PMID
Dorrestein PC, Gallo RL, Knight R. Microbial Skin Inhabitants: Friends Forever. Cell. 165: 771-772. PMID
Quinn RA, Vermeij MJ, Hartmann AC, Galtier d'Auriac I, Benler S, Haas A, Quistad SD, Lim YW, Little M, Sandin S, , Dorrestein PC, Rohwer F. Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence. Proceedings. Biological Sciences / the Royal Society. 283. PMID
Moran MA, Kujawinski EB, Stubbins A, Fatland R, Aluwihare LI, Buchan A, , Dorrestein PC, , Hess NJ, Howe B, Longnecker K, Medeiros PM, Niggemann J, Obernosterer I, et al. Deciphering ocean carbon in a changing world. Proceedings of the National Academy of Sciences of the United States of America. PMID
Spraker JE, , Lowe TM, Dorrestein PC, Keller NP. Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues. The Isme Journal. PMID
, Blainey PC, Cardon ZG, Chun M, , Dorrestein PC, , Gilbert JA, Jansson JK, Knight R, Miller JF, Ozcan A, Prather KA, Quake SR, Ruby EG, et al. Tools for the Microbiome: Nano and Beyond. Acs Nano. 10: 6-37. PMID
Sandoval-Calderón M, Nguyen DD, Kapono CA, Herron P, Dorrestein PC, Sohlenkamp C. Plasticity of Streptomyces coelicolor Membrane Composition Under Different Growth Conditions and During Development. Frontiers in Microbiology. 6: 1465. PMID
Nonejuie P, Trial RM, Newton GL, Lamsa A, Ranmali Perera V, Aguilar J, , Dorrestein PC, Pogliano J, . Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis. The Journal of Antibiotics. PMID
, , , Garg N, Bailey BA, Lim YW, Conrad DJ, Dorrestein PC, Rohwer FL. Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome. The Isme Journal. PMID
de Bruijn I, Cheng X, de Jager V, Expósito RG, Watrous J, Patel N, Postma J, Dorrestein PC, Kobayashi D, Raaijmakers JM. Comparative genomics and metabolic profiling of the genus Lysobacter. Bmc Genomics. 16: 991. PMID
, Blaser MJ, Brodie EL, Chun M, Dangl JL, Donohue TJ, Dorrestein PC, Gilbert JA, Green JL, Jansson JK, Knight R, Maxon ME, , Miller JF, , et al. MICROBIOME. A unified initiative to harness Earth's microbiomes. Science (New York, N.Y.). 350: 507-8. PMID
da Silva RR, Dorrestein PC, Quinn RA. Illuminating the dark matter in metabolomics. Proceedings of the National Academy of Sciences of the United States of America. 112: 12549-50. PMID
Agarwal V, Diethelm S, Ray L, Garg N, Awakawa T, Dorrestein PC, . Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. Organic Letters. 17: 4452-5. PMID
Liu Y, Rzeszutek E, van der Voort M, Wu CH, Thoen E, Skaar I, Bulone V, Dorrestein PC, Raaijmakers JM, de Bruijn I. Diversity of Aquatic Pseudomonas Species and Their Activity against the Fish Pathogenic Oomycete Saprolegnia. Plos One. 10: e0136241. PMID
Hoffmann T, Dorrestein PC. Homogeneous Matrix Deposition on Dried Agar for MALDI Imaging Mass Spectrometry of Microbial Cultures. Journal of the American Society For Mass Spectrometry. 26: 1959-62. PMID
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, , Fewer DP, ... ... Dorrestein PC, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID
Rateb ME, Zhai Y, Ehrner E, , Wang X, Tabudravu J, Ebel R, Bibb M, Kyeremeh K, Dorrestein PC, Hong K, Jaspars M, Deng H. Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate. Organic & Biomolecular Chemistry. 13: 9585-92. PMID
Patin NV, Duncan KR, Dorrestein PC, . Competitive strategies differentiate closely related species of marine actinobacteria. The Isme Journal. PMID
Liaw CC, , Shih CJ, Tseng SP, Lai YM, Hsu CH, Dorrestein PC, Yang YL. Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach. Scientific Reports. 5: 12856. PMID
Boudreau PD, , Mehrotra S, Desfor S, Korobeynikov A, , Murray TF, , Dorrestein PC, . Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. Plos One. 10: e0133297. PMID
Van Der Voort M, Meijer HJ, Schmidt Y, Watrous J, Dekkers E, Mendes R, Dorrestein PC, Gross H, Raaijmakers JM. Genome mining and metabolic profiling of the rhizosphere bacterium Pseudomonas sp. SH-C52 for antimicrobial compounds. Frontiers in Microbiology. 6: 693. PMID
Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, , Duggan BM, Di Marzo V, , Dorrestein PC, , . Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. Journal of Natural Products. PMID
Gao WW, Xiao RQ, Peng BL, Xu HT, Shen HF, Huang MF, Shi TT, Yi J, Zhang WJ, , Gao X, Lin XZ, Dorrestein PC, , Liu W. Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proceedings of the National Academy of Sciences of the United States of America. 112: E3327-36. PMID
Teufel R, Stull F, Meehan MJ, Michaudel Q, Dorrestein PC, Palfey B, . Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. Journal of the American Chemical Society. 137: 8078-85. PMID
Edlund A, , Yooseph S, Hall AP, Nguyen DD, Dorrestein PC, , He X, Lux R, , McLean JS. Meta-omics uncover temporal regulation of pathways across oral microbiome genera during in vitro sugar metabolism. The Isme Journal. PMID
Song J, Liu X, Rao TS, Chang L, Meehan MJ, Blevitt JM, Wu J, Dorrestein PC, . Phenotyping Drug Polypharmacology via Eicosanoid Profiling of Blood. Journal of Lipid Research. PMID
Luzzatto-Knaan T, Melnik AV, Dorrestein PC. Mass spectrometry tools and workflows for revealing microbial chemistry. The Analyst. PMID
, Bormans M, Gugger M, Dorrestein PC, . Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions. Environmental Microbiology. PMID
Oetjen J, Veselkov K, Watrous J, McKenzie JS, Becker M, Hauberg-Lotte L, Kobarg JH, Strittmatter N, Mróz AK, Hoffmann F, Trede D, Palmer A, Schiffler S, Steinhorst K, Aichler M, ... ... Dorrestein PC, et al. Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry. Gigascience. 4: 20. PMID
Duncan KR, Crüsemann M, Lechner A, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, , Dorrestein PC, . Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chemistry & Biology. 22: 460-71. PMID
Garg N, Kapono C, Lim YW, Koyama N, Vermeij MJ, Conrad D, Rohwer F, Dorrestein PC. Mass spectral similarity for untargeted metabolomics data analysis of complex mixtures. International Journal of Mass Spectrometry. 377: 719-717. PMID
Bouslimani A, Porto C, , Wang M, , Gonzalez A, Berg-Lyon D, Ackermann G, Moeller Christensen GJ, Nakatsuji T, Zhang L, Borkowski AW, Meehan MJ, Dorrestein K, , ... ... Dorrestein PC, et al. Molecular cartography of the human skin surface in 3D. Proceedings of the National Academy of Sciences of the United States of America. 112: E2120-9. PMID
, Fang J, Dorrestein PC. Mass Spectrometry Analysis of Pseudomonas aeruginosa Treated with Azithromycin. Journal of the American Society For Mass Spectrometry. 26: 873-7. PMID
Michelsen CF, Watrous J, Glaring MA, , Koyama N, Dorrestein PC, Stougaard P. Nonribosomal peptides, key biocontrol components for Pseudomonas fluorescens In5, isolated from a Greenlandic suppressive soil. Mbio. 6: e00079. PMID
Mascuch SJ, Moree WJ, Hsu CC, Turner GG, Cheng TL, Blehert DS, , Frick WF, Meehan MJ, Dorrestein PC, . Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. Plos One. 10: e0119668. PMID
, Meehan MJ, Gu S, Chen Z, Zhang W, Zhang G, Liu L, , Dorrestein PC, Xu Y, , . Mechanism of action of thalassospiramides, a new class of calpain inhibitors. Scientific Reports. 5: 8783. PMID
Bleich R, Watrous JD, Dorrestein PC, , . Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 112: 3086-91. PMID
, Schwartz SL, Lee J, Korobeynikov A, Dorrestein PC, , . Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. Journal of Natural Products. 78: 493-9. PMID
He X, McLean JS, Edlund A, Yooseph S, Hall AP, , Dorrestein PC, , Hunter RC, , , Lux R, . Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle. Proceedings of the National Academy of Sciences of the United States of America. 112: 244-9. PMID
Hsu CC, Dorrestein PC. Visualizing life with ambient mass spectrometry. Current Opinion in Biotechnology. 31: 24-34. PMID
, Gulland LE, Dorrestein PC, . Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform. Acs Synthetic Biology. 4: 414-20. PMID
Liaw CC, Chen PC, Shih CJ, Tseng SP, Lai YM, Hsu CH, Dorrestein PC, Yang YL. Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach Scientific Reports. 5. DOI: &
Song C, Mazzola M, Cheng X, Oetjen J, Alexandrov T, Dorrestein P, Watrous J, Van Der Voort M, Raaijmakers JM. Molecular and chemical dialogues in bacteria-protozoa interactions Scientific Reports. 5. DOI: &
Brito ?, Gaifem J, Ramos V, Glukhov E, Dorrestein PC, , Vasconcelos VM, Mendes MV, Tamagnini P. Bioprospecting Portuguese Atlantic coast cyanobacteria for bioactive secondary metabolites reveals untapped chemodiversity Algal Research. 9: 218-226. DOI: &
, , , Olson J, Dorrestein PC, . N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system have cytotoxic and proinflammatory activities. Chemistry & Biology. 21: 1457-62. PMID
Sharon G, Garg N, Debelius J, Knight R, Dorrestein PC, Mazmanian SK. Specialized metabolites from the microbiome in health and disease. Cell Metabolism. 20: 719-30. PMID
Medema MH, Paalvast Y, Nguyen DD, Melnik A, Dorrestein PC, Takano E, Breitling R. Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products. Plos Computational Biology. 10: e1003822. PMID
Mohimani H, , , , Dorrestein PC, . NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery. Journal of Natural Products. PMID
Fang J, Dorrestein PC. Emerging mass spectrometry techniques for the direct analysis of microbial colonies. Current Opinion in Microbiology. 19: 120-9. PMID
Moree WJ, McConnell OJ, Nguyen DD, , Yang YL, Zhao X, , Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, , ... ... Dorrestein PC, et al. Microbiota of healthy corals are active against fungi in a light-dependent manner. Acs Chemical Biology. 9: 2300-8. PMID
Dorrestein PC, Mazmanian SK, Knight R. Finding the missing links among metabolites, microbes, and the host. Immunity. 40: 824-32. PMID
Mohimani H, , , Wang M, Purvine SO, , Brewer HM, Pasa-Tolic L, Bandeira N, , , Dorrestein PC. Automated genome mining of ribosomal peptide natural products. Acs Chemical Biology. 9: 1545-51. PMID
Dorrestein PC. Editorial: Mass spectrometry of small molecules and natural products. Natural Product Reports. 31: 704-5. PMID
Bouslimani A, , Garg N, Dorrestein PC. Mass spectrometry of natural products: current, emerging and future technologies. Natural Product Reports. 31: 718-29. PMID
Ursell LK, Haiser HJ, Van Treuren W, Garg N, Reddivari L, Vanamala J, Dorrestein PC, , Knight R. The intestinal metabolome: an intersection between microbiota and host. Gastroenterology. 146: 1470-6. PMID
, Haeckl FP, Boudreau PD, Byrum T, Dorrestein PC, Valeriote FA, . Lipopeptides from the tropical marine cyanobacterium Symploca sp. Journal of Natural Products. 77: 969-75. PMID
, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, , , Dorrestein PC, . Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Molecular & Cellular Proteomics : McP. 13: 1262-72. PMID
, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, , , Dorrestein PC. Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. Journal of Bacteriology. 196: 1683-93. PMID
Yamanaka K, Reynolds KA, , , , , Dorrestein PC, . Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proceedings of the National Academy of Sciences of the United States of America. 111: 1957-62. PMID
Winnikoff JR, Glukhov E, Watrous J, Dorrestein PC, . Quantitative molecular networking to profile marine cyanobacterial metabolomes. The Journal of Antibiotics. 67: 105-12. PMID
Schorn M, Zettler J, , Dorrestein PC, , Kaysser L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. Acs Chemical Biology. 9: 301-9. PMID
, Lamsa A, Wong WR, Boudreau PD, , Peng Y, Moree WJ, Duggan BM, , , , , Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. The Journal of Antibiotics. 67: 99-104. PMID
, Ziemert N, , Duggan BM, , Dorrestein PC, . Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proceedings of the National Academy of Sciences of the United States of America. 110: E4407-16. PMID
Watrous J, Roach P, Heath B, Alexandrov T, , Dorrestein PC. Metabolic profiling directly from the Petri dish using nanospray desorption electrospray ionization imaging mass spectrometry. Analytical Chemistry. 85: 10385-91. PMID
, , , Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, , Zhang L, Debonsi HM, , ... Dorrestein PC, et al. Molecular networking as a dereplication strategy. Journal of Natural Products. 76: 1686-99. PMID
Davis J, Fricke WF, , , Dorrestein PC, . Characterization of the bacterial community of the chemically defended Hawaiian sacoglossan Elysia rufescens. Applied and Environmental Microbiology. 79: 7073-81. PMID
, Zhang Y, Colabroy KL, , , Dorrestein PC, , Ealick SE. Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallographica. Section D, Biological Crystallography. 69: 1685-96. PMID
Hsu CC, White NM, , Lin EC, Poon T, Banerjee I, Chen J, , , Dorrestein PC. Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning. Proceedings of the National Academy of Sciences of the United States of America. 110: 14855-60. PMID
Traxler MF, Watrous JD, Alexandrov T, Dorrestein PC, . Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolome. Mbio. 4. PMID
Moree WJ, , Zhao X, , Aparicio M, Atencio L, Ballesteros J, S??nchez J, Gavil??n RG, Guti?(C)rrez M, Dorrestein PC. Imaging mass spectrometry of a coral microbe interaction with fungi. Journal of Chemical Ecology. 39: 1045-54. PMID
Hsu CC, , Peng Y, Fang J, , Mascuch SJ, M?,ller KA, Alazzeh EK, Pikula J, , Zeng Y, Wolfe BE, Dutton RJ, , Zhang L, ... ... Dorrestein PC, et al. Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Analytical Chemistry. 85: 7014-8. PMID
Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, , van de Wiel C, ... ... Dorrestein PC, et al. MS/MS networking guided analysis of molecule and gene cluster families. Proceedings of the National Academy of Sciences of the United States of America. 110: E2611-20. PMID
Pérez Morales TG, Ho TD, , Dorrestein PC, . Production of the cannibalism toxin SDP is a multistep process that requires SdpA and SdpB. Journal of Bacteriology. 195: 3244-51. PMID
, , Nett M, , Duggan BM, Dorrestein PC, . Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem : a European Journal of Chemical Biology. 14: 955-62. PMID
, , Alexandrov T, Dorrestein PC. Data-independent microbial metabolomics with ambient ionization mass spectrometry. Journal of the American Society For Mass Spectrometry. 24: 1167-76. PMID
, Dorrestein PC. Analytical chemistry: Virulence caught green-handed. Nature Chemistry. 5: 155-7. PMID
, , Gusarov I, , von K?ckritz-Blickwede M, Anik S, Borkowski AW, Dorrestein PC, , . Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. The Journal of Biological Chemistry. 288: 6417-26. PMID
Watrous JD, , Hsu CC, Moree WJ, Duggan BM, Alexandrov T, Dorrestein PC. Microbial metabolic exchange in 3D. The Isme Journal. 7: 770-80. PMID
, Xu Y, Lu L, , Shao Z, Al-Suwailem AM, Dorrestein PC, , . Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria. Journal of the American Chemical Society. 135: 1155-62. PMID
Arnison PG, Bibb MJ, Bierbaum G, , Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... Dorrestein PC, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID
Song J, Liu X, Wu J, Meehan MJ, Blevitt JM, Dorrestein PC, . A highly efficient, high-throughput lipidomics platform for the quantitative detection of eicosanoids in human whole blood. Analytical Biochemistry. 433: 181-8. PMID
Lohr F, Jenniches I, Frizler M, Meehan MJ, Sylvester M, Schmitz A, Gütschow M, Dorrestein PC, K?nig GM, Sch?berle TF. α,β → β,γ double bond migration in corallopyronin A biosynthesis Chemical Science. 4: . DOI: &
, Dorrestein PC, . Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chemistry & Biology. 19: 1600-10. PMID
, , , Donald C, , Sanderson-Smith M, Dorrestein PC, . A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides. The Journal of Biological Chemistry. 287: 40891-7. PMID
, Alexandrov T, Higginbottom SK, Song J, , , Sonnenburg JL, Dorrestein PC. Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations. Analytical Chemistry. 84: 9259-67. PMID
Boudreau PD, Byrum T, , Dorrestein PC, . Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. Journal of Natural Products. 75: 1560-70. PMID
Moree WJ, , Wu CH, Bandeira N, Cornett DS, Duggan BM, Dorrestein PC. Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 109: 13811-6. PMID
Hoefler BC, Gorzelnik KV, , Hendricks N, Dorrestein PC, . Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition. Proceedings of the National Academy of Sciences of the United States of America. 109: 13082-7. PMID
, , Simkovsky R, Watrous JD, Trial RM, , Wenter R, , , , Dorrestein PC. Primer on agar-based microbial imaging mass spectrometry. Journal of Bacteriology. 194: 6023-8. PMID
Roberts AA, Schultz AW, , Dorrestein PC, . Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. Fems Microbiology Letters. 335: 95-103. PMID
, Xu Y, Yang YL, , , Edlund A, Duong T, , Molnár I, , , , Liaw CC, , , ... Dorrestein PC, et al. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. Journal of Proteomics. 75: 5069-76. PMID
Guthals A, Watrous JD, Dorrestein PC, Bandeira N. The spectral networks paradigm in high throughput mass spectrometry. Molecular Biosystems. 8: 2535-44. PMID
Watrous J, Roach P, Alexandrov T, Heath BS, , , van der Voort M, , Gross H, Raaijmakers JM, , , Bandeira N, Dorrestein PC. Mass spectral molecular networking of living microbial colonies. Proceedings of the National Academy of Sciences of the United States of America. 109: E1743-52. PMID
Lamsa A, , Dorrestein PC, . The Bacillus subtilis cannibalism toxin SDP collapses the proton motive force and induces autolysis. Molecular Microbiology. 84: 486-500. PMID
Xu Y, , Nam SJ, Lu L, Al-Suwailem AM, Zheng H, Fenical W, Dorrestein PC, , . Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. Journal of the American Chemical Society. 134: 8625-32. PMID
, , , , , , Malone CL, Derieux J, , , , Dorrestein PC, . Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. The Journal of Biological Chemistry. 287: 13889-98. PMID
, Dorrestein PC. The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes. Current Opinion in Microbiology. 15: 147-54. PMID
, , , Dorrestein PC. Microbial metabolic exchange--the chemotype-to-phenotype link. Nature Chemical Biology. 8: 26-35. PMID
Yang L, , Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, . ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 147: 773-88. PMID
Mohimani H, , Yang YL, Gaud??ncio SP, Fenical W, Dorrestein PC, . Multiplex de novo sequencing of peptide antibiotics. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 18: 1371-81. PMID
, Abeydeera ND, , Pai PJ, Dorrestein PC, , Ealick SE, . Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature. 478: 542-6. PMID
, , Yang YL, , Dorrestein PC. Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. Journal of the American Chemical Society. 133: 18010-3. PMID
, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, , , Dorrestein PC. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nature Chemical Biology. 7: 794-802. PMID
Szu PH, Govindarajan S, Meehan MJ, , Nguyen DD, Dorrestein PC, Minshull J, . Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chemistry & Biology. 18: 1021-31. PMID
Mohimani H, , Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, . Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. Journal of Proteome Research. 10: 4505-12. PMID
Watrous JD, Dorrestein PC. Imaging mass spectrometry in microbiology. Nature Reviews. Microbiology. 9: 683-94. PMID
, Daly M, Bahrainwala T, , Dorrestein PC. Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation. Bioorganic & Medicinal Chemistry. 19: 6639-44. PMID
, Choi H, , Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, , . Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products. 74: 1737-43. PMID
Mohimani H, Yang YL, , Hsieh PW, Dorrestein PC, . Sequencing cyclic peptides by multistage mass spectrometry. Proteomics. 11: 3642-50. PMID
Jones CS, , Dorrestein PC, . Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry. Bioorganic & Medicinal Chemistry. 19: 6620-7. PMID
, , , , Hamby M, , , Dorrestein PC. Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Microbiology (Reading, England). 157: 2485-92. PMID
Yang YL, Xu Y, , , Meehan MJ, , Bandeira N, Dorrestein PC. Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Angewandte Chemie (International Ed. in English). 50: 5839-42. PMID
Jones AC, , Podell S, Hess WR, Klages S, , Niessen S, Hoover H, Rothmann M, Lasken RS, Yates JR, Reinhardt R, Kube M, , Allen EE, ... Dorrestein PC, et al. Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proceedings of the National Academy of Sciences of the United States of America. 108: 8815-20. PMID
, Ishoey T, , , Coates RC, , , Dorrestein PC, , Lasken R, . Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. Plos One. 6: e18565. PMID
Kalaitzis JA, , Meluzzi D, Xiang L, Izumikawa M, Dorrestein PC, . Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorganic & Medicinal Chemistry. 19: 6633-8. PMID
Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, , , Beauchemin N, , Clark BR, , Eust??quio AS, Freel K, , , ... ... Dorrestein PC, et al. Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology. 77: 3617-25. PMID
, , , Mohimani H, Byrum T, , Dorrestein PC, Spadafora C, . Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products. 74: 928-36. PMID
, Choi H, , Rottacker EC, , Dorrestein PC, . Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environmental Microbiology. 13: 1601-10. PMID
, Jones AC, Byrum T, Dorrestein PC, . Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. 108: 5226-31. PMID
Bruand J, Sistla S, Mériaux C, Dorrestein PC, Gaasterland T, Ghassemian M, Wisztorski M, Fournier I, Salzet M, , . Automated querying and identification of novel peptides using MALDI mass spectrometric imaging. Journal of Proteome Research. 10: 1915-28. PMID
Watrous JD, Alexandrov T, Dorrestein PC. The evolving field of imaging mass spectrometry and its impact on future biological research. Journal of Mass Spectrometry : Jms. 46: 209-22. PMID
Dorrestein PC, . 'Omics' of natural products and redox biology. Current Opinion in Chemical Biology. 15: 3-4. PMID
, Karr JR, Watrous JD, Dorrestein PC. Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes. Current Opinion in Chemical Biology. 15: 79-87. PMID
Meehan MJ, , Zhao X, Xu W, , Dorrestein PC. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. Biochemistry. 50: 287-99. PMID
, Patel AD, Niessen S, Meehan M, , , Rothmann M, , Dorrestein PC, , . Practical 4'-phosphopantetheine active site discovery from proteomic samples. Journal of Proteome Research. 10: 320-9. PMID
, Cooper HJ, Dorrestein PC, Tang K, . Proteomics. Journal of Biomedicine & Biotechnology. . PMID
Liu X, Inbar Y, Dorrestein PC, Wynne C, Edwards N, Souda P, Whitelegge JP, , . Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach. Molecular & Cellular Proteomics : McP. 9: 2772-82. PMID
, Yang YL, Xu Y, Lamsa A, , , , , , , , Pogliano J, , , Dorrestein PC. Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 107: 16286-90. PMID
, Dorrestein PC. Metalloenzymes: Natural product nitrosation. Nature Chemical Biology. 6: 636-7. PMID
O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, . Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. Plos One. 5: e11716. PMID
, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, , Ohgi KA, Benner C, Garcia-Bassets I, , , Dorrestein PC, Glass CK, . PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 466: 508-12. PMID
, Lee SW, , , Dahesh S, , Bandeira N, , , Dorrestein PC. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. The Journal of Biological Chemistry. 285: 28220-8. PMID
Le??o PN, Pereira AR, , , , Dorrestein PC, K??nig GM, , . Synergistic allelochemicals from a freshwater cyanobacterium. Proceedings of the National Academy of Sciences of the United States of America. 107: 11183-8. PMID
He C, Nora GP, , Kerr ID, Hansell E, Hirata K, , Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, , Eckmann L, Dorrestein PC, et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27. PMID
Zhou H, , , Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, . Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society. 132: 4530-1. PMID
Watrous J, Hendricks N, Meehan M, Dorrestein PC. Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry. Analytical Chemistry. 82: . PMID
Watrous J, , , Patel A, Hook V, , Barry CE, Bark S, Dorrestein PC. Expansion of the mycobacterial "PUPylome". Molecular Biosystems. 6: 376-85. PMID
Taniguchi M, Nunnery JK, , , Byrum T, Dorrestein PC, . Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 73: 393-8. PMID
, Meehan MJ, Dorrestein PC. Applications of modern mass spectrometry techniques in natural products chemistry Comprehensive Natural Products Ii: Chemistry and Biology. 9: 389-456.&
Jones AC, , , Dorrestein PC, . Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. Bmc Microbiology. 9: 247. PMID
, Yang YL, Watrous J, , Dorrestein PC. Imaging mass spectrometry of natural products. Natural Product Reports. 26: 1521-34. PMID
Yang YL, Xu Y, , Dorrestein PC. Translating metabolic exchange with imaging mass spectrometry. Nature Chemical Biology. 5: 885-7. PMID
, Dorrestein PC. Secondary metabolomics: natural products mass spectrometry goes global. Acs Chemical Biology. 4: 599-601. PMID
, Yang YL, , Dorrestein PC, La Clair JJ, Fenical W. Marinopyrrole A target elucidation by acyl dye transfer. Journal of the American Chemical Society. 131: 12094-6. PMID
, Bandeira N, , Ghassemian M, , , , Dorrestein PC, . Dereplication and de novo sequencing of nonribosomal peptides. Nature Methods. 6: 596-9. PMID
, Meehan MJ, Xu W, Dorrestein PC, . Acyltransferase mediated polyketide release from a fungal megasynthase. Journal of the American Chemical Society. 131: 8388-9. PMID
O'Hayre M, Salanga CL, Dorrestein PC, . Phosphoproteomic analysis of chemokine signaling networks. Methods in Enzymology. 460: 331-46. PMID
, Dorrestein PC, . Probing marine natural product defenses with DESI-imaging mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 106: 7269-70. PMID
, , Meluzzi D, Bandeira N, Gutierrez M, , Schultz AW, , , , , Dorrestein PC. Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Analytical Chemistry. 81: 4200-9. PMID
, , Boshoff HI, Dorrestein PC, Barry CE. Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein. The Journal of Biological Chemistry. 284: 3069-75. PMID
Pouwels LJ, Zhang L, Chan NH, Dorrestein PC, . Kinetic isotope effect studies on the de novo rate of chromophore formation in fast- and slow-maturing GFP variants. Biochemistry. 47: 10111-22. PMID
, Coates C, Simmons L, , , Dorrestein PC. Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Molecular Biosystems. 4: 562-70. PMID
Lee SW, , , , , , Dorrestein PC, , . Discovery of a widely distributed toxin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 105: 5879-84. PMID
, Giang K, , Ma CT, Huynh N, , Dorrestein PC, , Adams JA, . A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Molecular Cell. 29: 563-76. PMID
, , Hilmey DG, , Dorrestein PC, . Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. Journal of the American Chemical Society. 130: 3043-52. PMID
, Coates RC, Clark BR, , , , Dorrestein PC, . Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages. Proceedings of the National Academy of Sciences of the United States of America. 105: 4587-94. PMID
Zhang J, Van Lanen SG, Ju J, , Dorrestein PC, Li W, , . A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 1460-5. PMID
Meluzzi D, Zheng WH, , , Dorrestein PC. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorganic & Medicinal Chemistry Letters. 18: 3107-11. PMID
, , Dorrestein PC, , . Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chemistry & Biology. 14: 835-46. PMID
, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, . Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. The Journal of Biological Chemistry. 282: 16362-8. PMID
, , , Dorrestein PC, , , , , . Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chemistry & Biology. 14: 303-12. PMID
Dorrestein PC, . Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Natural Product Reports. 23: 893-918. PMID
Dorrestein PC, , , , , , , , . Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry. 45: 12756-66. PMID
, Dorrestein PC, , . Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society. 128: 12600-1. PMID
Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, , . The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. Journal of the American Chemical Society. 128: 10386-7. PMID
Van Lanen SG, Lin S, Dorrestein PC, , . Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. The Journal of Biological Chemistry. 281: 29633-40. PMID
, , , , Dorrestein PC. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8977-82. PMID
, , , Dorrestein PC, , , . Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 7: 904-7. PMID
Howarth M, Chinnapen DJ, Gerrow K, Dorrestein PC, Grandy MR, , , . A monovalent streptavidin with a single femtomolar biotin binding site. Nature Methods. 3: 267-73. PMID
Dorrestein PC, Blackhall J, , , , , McLaughlin S, Lin M, , , , . Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 45: 1537-46. PMID
, Dorrestein PC, Blackhall JR, , . Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. Journal of the American Chemical Society. 127: 14986-7. PMID
Dorrestein PC, , , , . Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 13843-8. PMID
, Baumgart S, Dorrestein PC, , , . Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. Journal of the American Chemical Society. 127: 11602-3. PMID
Van Lanen SG, Dorrestein PC, , , Ju J, , . Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. Journal of the American Chemical Society. 127: 11594-5. PMID
, Dorrestein PC, , , . Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. Journal of the American Society For Mass Spectrometry. 16: 1052-9. PMID
Garneau S, Dorrestein PC, , . Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry. 44: 2770-80. PMID
Dorrestein PC, , , . The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS. Chemistry & Biology. 11: 1373-81. PMID
, Dorrestein PC, , , , , Ealick SE. Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry. 43: 11647-57. PMID
Dorrestein PC, , Taylor SV, , . The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. Journal of the American Chemical Society. 126: 3091-6. PMID
, Dorrestein PC, , , , . Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. 42: 12430-8. PMID
Dorrestein PC, Poole K, . Formation of the chromophore of the pyoverdine siderophores by an oxidative cascade. Organic Letters. 5: 2215-7. PMID
, Dorrestein PC, , . Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade. Organic Letters. 5: 2211-3. PMID
, Dorrestein PC, , Augustine AM, , Ealick SE. Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry. 42: 2971-81. PMID
Anand R, Dorrestein PC, , , Ealick SE. Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution. Biochemistry. 41: 7659-69. PMID
Mansour G, Creedon W, Dorrestein PC, Maxka J, , Helburn R. Synthesis and physical characterization of some new hydrophobic forms of the solvatochromic N,N-dialkyl-p-nitroanilines. The Journal of Organic Chemistry. 66: 4050-4. PMID
, Dorrestein PC, Pilley MM. Design of supramolecular layers via self-assembly of imidazole and carboxylic acids Crystal Growth and Design. 1: 29-38.&
, Dorrestein PC, Pilley MM, Foote MM, Lundburg JL, Henning RW, Schultz AJ, Manson JL. Design of layered crystalline materials using coordination chemistry and hydrogen bonds Journal of the American Chemical Society. 122: . DOI: &