opening in the cell 5th...

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Accompanying their father on a temporary job relocation, two sisters, Mie and Ai, find themselves dismayed at the creepy vibe of their new home. The two bedrooms on the second floor in particular almost seem to be possessed. Sensing something is wrong, Mie ventures into Ai's bedroom one day, when all of a sudden, her cell phone rings. However, the voice on the other end is disturbingly not human-like. Compounding Mie's fear is the sudden change in the appearance of Ai, who goes from stylish and beautiful too worn out and emaciated just like that. Suspecting the mysterious phone call, Mie begins to put the pieces of the puzzle together…【G2comix】《DokiDoki Series》
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with a red, pock-marked facepast the still foulerRegions involved in the opening of CIC-2 chloride channel by voltag...
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FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListChoose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 1334533FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mailAdd to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
1992 Dec 24-31;360(.Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume.1, , , .1Centre for Molecular Neurobiology (ZMNH), Hamburg University, Germany.AbstractRegulation of cell volume is essential for every cell and is accomplished by the regulated loss or gain of intracellular ions or other osmolytes. Regulatory volume decrease often involves the parallel activation of potassium and chloride channels. Overexpression of P-glycoprotein leads to volume-activated Cl- currents but its physiological importance for volume regulation is unclear. CIC-2 is a ubiquitously expressed Cl- channel activatable by non-physiologically strong hyperpolarization. We now show that CIC-2 can be activated by extracellular hypotonicity, which suggests that it has a widespread role in volume regulation. Domains necessary for activation by both voltage and volume are localized to the amino terminus. Mutations in an 'essential' region lead to constitutively open channels unresponsive to medium tonicity, whereas deletions in a 'modulating' region produce partially opened channels responsive to both hypo- and hypertonicity. These domains can be transplanted to different regions of the protein without loss of function.PMID: 1334533
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