McArdle萌是什么意思思?

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【求助】APC(min/+)是什么意思?
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这个帖子发布于6年零125天前,其中的信息可能已发生改变或有所发展。
最近刚开始实验,查文献发现 APC(min/+)mice不懂什么意思,尤其是(min/+),既不是-/-,也不是+/-。请懂这个的朋友解释一些
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请读一读这个论文Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8977-81.ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Moser AR, Mattes EM, Dove WF, Lindstrom MJ, Haag JD, Gould MN.McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.AbstractApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.
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由于Apc基因第850号密码子等位突变(allele mutation)引起肠道多发性腺瘤, 因而被称之为Min(multiple intestinal neoplasia)小鼠。APC(min/+)小鼠具有肠道多发性腺瘤特征,。
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貌似 min 是multiple intestinal neoplasia ,是一种APC基因突变小鼠,MIN是指表型,APC(min/+)指的是APC两个等位基因一个发生突变,一个正常表达吧
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请上传整段文献,否则解释不准。“min”一般是指微弱表达的意思。
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The Apc(Min/+) mouse is a popular animal model for studies of human colon cancer(Min/+) 与(-/-)和(+/-)的区别是什么?还有没有(Min/-)或者其他形式的? 谢谢
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(Min/+)的意思是等位基因一个表达,另一个弱表达。(-/-)的意思是等位基因都不表达,完全缺失。(+/-)的意思是等位基因一个表达,另一个不表达。
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貌似 min 是multiple intestinal neoplasia ,是一种APC基因突变小鼠,MIN是指表型,APC(min/+)指的是APC两个等位基因一个发生突变,一个正常表达吧
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兔子子子 貌似 min 是multiple intestinal neoplasia ,是一种APC基因突变小鼠,MIN是指表型,APC(min/+)指的是APC两个等位基因一个发生突变,一个正常表达吧同意,本人上面的相关解释不准。
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请读一读这个论文Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8977-81.ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Moser AR, Mattes EM, Dove WF, Lindstrom MJ, Haag JD, Gould MN.McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.AbstractApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.
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由于Apc基因第850号密码子等位突变(allele mutation)引起肠道多发性腺瘤, 因而被称之为Min(multiple intestinal neoplasia)小鼠。APC(min/+)小鼠具有肠道多发性腺瘤特征,。
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陆军鱼 The Apc(Min/+) mouse is a popular animal model for studies of human colon cancer(Min/+) 与(-/-)和(+/-)的区别是什么?还有没有(Min/-)或者其他形式的? 谢谢求购小鼠
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