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Autor:Gao S; Fan J; Wang ZEndere?o:Department of Pediatrics, Linyi People's Hospital, Linyi City, China.
Título:Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity.
Fonte:Int Arch Allergy I 171(3-4):194-202, 2016.
ISSN:País de publica??o:Switzerland
Idioma:engResumo:BACKGROUND: The aim of this study was to explore whether serum baseline tryptase (sBT) levels might be a useful marker not only for the accurate diagnosis of childhood asthma, but also for the prediction of disease severity. METHODS: A total of 114 asthmatic children were enrolled in this study, 36 of whom had mild intermittent asthma, 38 had mild persistent asthma, and 40 had moderate to severe persistent asthma. Additionally, 34 age-matched healthy children were enrolled as controls. The sBT levels of these populations were measured using a fluoroenzymeimmunoassay kit. The diagnostic performance of sBT levels and their correlation with asthma severity were systematically investigated using receiver operating characteristic (ROC) analysis and correlation analysis. RESULTS: Children with mild and moderate to severe persistent asthma had significantly increased sBT levels as compared to those with mild intermittent asthma and healthy controls. ROC analysis further demonstrated that sBT levels not only appear to be highly sensitive and specific for distinguishing asthmatic children from healthy controls, but also show good accuracy for the differentiation of various asthmatic subgroups. Correlation analysis revealed that in all asthmatic subgroups sBT levels were significantly correlated with a variety of key markers that reflect the disease severity of asthma, including childhood asthma control test scores, serum IgE and interleukin-13 levels, blood eosinophil counts, and pulmonary test parameters. CONCLUSIONS: sBT levels may have a potential use in supporting a diagnosis of asthma in children and as a predictor of disease severity.
Tipo de publica??o: JOURNAL ARTICLE
Nome de subst?ncia:0 (Biomarkers);
(Immunoglobulin E); EC 3.4.21.59 (Tryptases)
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Autor:Micu GV; Staniceanu F; Sticlaru LC; Popp CG; Bastian AE; Gramada E; Pop G; Mateescu RB; Rimbas M; Archip B; Bleotu CTítulo:Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer.
Fonte:Rom J Intern M 54(2):113-20, 2016 Apr-Jun.
ISSN:País de publica??o:Germany
Idioma:engResumo:Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.
Tipo de publica??o: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de subst?ncia:0 (Antigens, CD); 0 (Biomarkers, Tumor); 0 (ENG protein, human); 0 (Endoglin); 0 (Receptors, Cell Surface); EC 3.4.21.59 (Tryptases)
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Autor:Tsujita J; Doi K; Nakahara M; Nakahara T; Kaku Y; Nishio K; Kan N; Sato Y; Nagata S; Nakao A; Yoshida M; Uchi H; Furue MTítulo:Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa).
Fonte:Fukuoka Igaku Z 107(1):12-7, 2016 Jan.
ISSN:XPaís de publica??o:Japan
Idioma:engResumo:The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
Tipo de publica??o: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de subst?ncia:0 (Cyclin-Dependent Kinase Inhibitor p16); EC 3.4.21.59 (Tryptases)
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Autor:Blanca-Lopez N; Campo P; Salas M; García Rodríguez C; Palomares F; Blanca M; Canto G; Feo Brito F; Rondon CEndere?o:Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
Título:Seasonal Local Allergic Rhinitis in Areas With High Concentrations of Grass Pollen.
Fonte:J Investig Allergol Clin I 26(2):83-91, 2016.
ISSN:País de publica??o:Spain
Idioma:engResumo:BACKGROUND: Local allergic rhinitis (LAR) is a phenotype of allergic rhinitis characterized by the presence of a localized immune response in the nasal mucosa of patients with negative skin prick test (SPT) results and undetectable serum specific IgE (sIgE). It unknown whether LAR is limited to areas with low or moderate aeroallergen exposure. OBJECTIVE: To explore the presence of LAR and the clinical and immunological characteristics of this entity in geographic areas with high grass pollen loads. METHODS: A cross-sectional observational study was carried out in 2 hospitals in central Spain (Madrid and Ciudad Real). Sixty-one patients with seasonal rhinitis and negative SPT results and undetectable serum sIgE were evaluated using a clinical questionnaire, determination of serum total IgE, and a nasal allergen provocation test (NAPT) with Phleum species. The response to NAPT was monitored using assessment of nasal symptoms, acoustic rhinometry, and determination of sIgE, tryptase, and eosinophil cationic protein in the nasal cavity. RESULTS: Seasonal LAR was detected in 37 patients (61%) using the techniques described above. Eleven percent of patients with LAR were adolescents or children, and 14% reported onset of rhinitis in childhood. Most patients reported persistent-moderate seasonal nasal symptoms, and 41% reported worsening of the disease during the last 2 years. Conjunctivitis was the most common comorbidity, affecting 95% of cases. CONCLUSIONS: LAR to grass pollen is relevant in patients with seasonal symptoms indicative of allergic rhinitis but with a negative skin test result who live in areas with high allergenic pollen loads. This entity should be included the differential diagnosis of rhinitis.
Tipo de publica??o: JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de subst?ncia:0 (Allergens);
(Immunoglobulin E); EC 3.1.27.- (Eosinophil Cationic Protein); EC 3.4.21.59 (Tryptases)
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Autor:Horiuchi T; Takazawa T; Saito STítulo:[A Case of Rocuronium-induced Anaphylaxis in Which Surgery was Subsequently Performed under General Anesthesia without Neuromuscular Blocking Agents].
Fonte:M 65(3):299-303, 2016 Mar.
ISSN:País de publica??o:Japan
Idioma:jpnResumo:We report here a case of rocuronium-induced anaphylactic shock in a 41-year-old woman. She was scheduled for partial hepatectomy due to liver metastasis of a pheochromocytoma. Anesthesia was induced with propofol, remifentanil, and rocuronium. Bag-mask ventilation was difficult, and her blood pressure fell to around 40 mmHg just after induction. Subsequently, her trachea was intubated and adrenaline was injected. However, due to the subsequent persistence of severe hypotension and hypoxia, cardiopulmonary resuscitation was necessary. Suspecting the development of pulmonary embolism or anaphylaxis, we performed transe however, no evidence of right heart dilatation was observed, indicating a low possibility of pulmonary embolism. Although her general condition was stabilized, surgery was canceled. Blood tests showed high serum histamine and tryptase levels, suggesting an Ig-E mediated allergic reaction. A skin test performed five weeks after anesthesia suggested that she had suffered from rocuronium-induced anaphylaxis. A skin test also showed cross-reactivity between rocuronium and vecuronium. Therefore, we did not use any neuromuscular agent for the subsequent surgery, which was completed uneventfully. Determining the drug responsible for anaphylaxis helps to prevent recurrence of anaphylaxis.
Tipo de publica??o: CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
Nome de subst?ncia:0 (Androstanols); 0 (Neuromuscular Blocking Agents); 0 (Piperidines); EC 3.4.21.59 (Tryptases); P10582JYYK (remifentanil); WRE554RFEZ (rocuronium); YI7VU623SF (Propofol)
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Autor:Paolino G; Moliterni E; Lopez T; Cardone M; Macrì G; Garelli V; Richetta AG; Didona D; Bottoni U; Calvieri SEndere?o:aDermatologic Clinic, Department of Dermatology, Sapienza University of Rome bDermatopathic Institute of the Immaculate-IRCCS, Department of Dermatology, Rome cUniversity of "Magna Graecia", Department of Dermatology, Catanzaro, Italy.
Título:Serum tryptase levels in melanoma patients: first results of clinicopathological features.
Fonte:Melanoma R 26(2):207-8, 2016 Apr.
ISSN:País de publica??o:England
Idioma:engTipo de publica??o: COMMENT; LETTER
Nome de subst?ncia:EC 3.4.21.59 (Tryptases)
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Autor:Bulai Livideanu C; Apoil PA; Lepage B; Eischen M; Laurent C; Laharrague P; Lamant L; Tournier E; Tavitian S; Pouplard C; Recher C; Laroche M; Mailhol C; Dubreuil P; Hermine O; Blancher A; Paul CEndere?o:Mastocytosis Expert Center of Midi-Pyrénées, Department of Dermatology, Paul Sabatier University, Toulouse University Hospital, Toulouse, France.
Título:Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.
Fonte:Clin Exp A 46(1):133-41, 2016 Jan.
ISSN:País de publica??o:England
Idioma:engResumo:BACKGROUND: Mastocytosis is difficult to diagnose, especially when systemic mast cell activation symptoms are not present or involve only one extracutaneous organ. OBJECTIVE: The main objective was to evaluate the accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis in patients with a clinical suspicion of mastocytosis. METHODS: We included all adult patients evaluated in our centre between December 2009 and 2013 for suspected mastocytosis as part of a standardized procedure and who had a bone marrow and serum tryptase assay on the same day. The diagnosis of systemic mastocytosis was established on the basis of the World Health Organization criteria as the gold standard. The accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis was assessed by a receiver operating characteristics curve analysis. The different sensitivity and specificity values, corresponding to the set of possible bone marrow tryptase level cut-off values, were estimated with 95% confidence intervals. RESULTS: Seventy-three patients were included. The diagnosis of systemic mastocytosis was established in 43 patients (58.9%). The median bone marrow tryptase level was 423 ug/L [95% CI: 217-868] in the systemic mastocytosis group and 7.5 ug/L [95% CI: 4.6-17.1] in the non-systemic mastocytosis group (P < 0.001). A cut-off value of 50 ug/L for bone marrow tryptase identified systemic mastocytosis with a sensitivity of 93.0% [95% CI: 80.9-98.5%] and a specificity of 90.0% [95% CI: 73.5-97.9%]. CONCLUSION AND CLINICAL RELEVANCE: The bone marrow tryptase level appears to be a valuable diagnostic criterion for confirming systemic mastocytosis. If this diagnosis can reliably be excluded by evaluation of the bone marrow tryptase level, there would be no need to perform a bone marrow biopsy.
Tipo de publica??o: JOURNAL ARTICLE
Nome de subst?ncia:0 (Biomarkers); EC 3.4.21.59 (Tryptases)
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Autor:Trautmann A; Seidl C; Stoevesandt J; Seitz CSEndere?o:Department of Dermatology and Allergy, University Hospital Würzburg, Würzburg, Germany.
Título:General anaesthesia-induced anaphylaxis: impact of allergy testing on subsequent anaesthesia.
Fonte:Clin Exp A 46(1):125-32, 2016 Jan.
ISSN:País de publica??o:England
Idioma:engResumo:BACKGROUND: Immunoglobulin E-mediated allergy to drugs and substances used during general anaesthesia as well as non-allergic drug hypersensitivity reactions may account for anaesthesia-induced anaphylaxis. As IgE-mediated anaphylaxis is a potentially life-threatening reaction, identification of the culprit allergen is essential to avoid anaphylaxis recurrence during subsequent general anaesthesia. OBJECTIVE: To study whether preventive recommendations derived from allergy testing after intraoperative anaphylaxis were followed in subsequent general anaesthesia. METHODS: Results of standardized allergy testing after anaesthesia-induced anaphylaxis and outcome of subsequent general anaesthesia were analysed retrospectively. RESULTS: Fifty-three of 107 patients were diagnosed with IgE-mediated allergy to a drug or substance used during general anaesthesia, and 54 patients were test negative. Twenty-eight of 29 allergy patients tolerated subsequent general anaesthesia uneventfully. One patient with cefazolin allergy suffered from anaphylaxis recurrence due to accidental reapplication of cefazolin. Twenty-two of 24 test-negative patients tolerated subsequent general anaesthesia, whereas two patients again developed anaphylaxis despite pre-medication regimens. CONCLUSION AND CLINICAL RELEVANCE: Our results confirm the practical impact of allergy testing in general anaesthesia-induced anaphylaxis. By identification of the allergen, it is possible to avoid allergic anaphylaxis during subsequent anaesthesia. In most cases, recommended pre-medication seems to prevent the recurrence of non-allergic drug hypersensitivity reactions.
Tipo de publica??o: JOURNAL ARTICLE
Nome de subst?ncia:0 (Allergens);
(Immunoglobulin E); EC 3.4.21.59 (Tryptases)
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Autor:du Toit-Prinsloo L; Morris NK; Meyer P; Saayman GEndere?o:Department of Forensic Medicine, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa. lorraine.dutoit@up.ac.za.
Título:Deaths from bee stings: a report of three cases from Pretoria, South Africa.
Fonte:Forensic Sci Med P 12(1):81-5, 2016 Mar.
ISSN:País de publica??o:United States
Idioma:engResumo:In South Africa bee stings are most commonly caused by either Apis mellifera capensis or A. mellifera scutellata, indigenous species which are notoriously aggressive when compared to European honey bees. According to Statistics South Africa, 109 deaths were documented for the period
as having been caused by hornets, wasps, and bees (ICD10-X26). This appears to be a small number but, as was reported in Australia, these statistics might be inaccurate due to either over- or underreporting of cases. We report 3 cases of fatalities due to bee stings, including one with postmortem features of diffuse intravascular coagulopathy. A brief overview of the venom of the honey bee, reactions following a bee sting and possible mechanisms of death are presented. Confirming the diagnosis in these cases may be very problematic for the forensic pathologist, as in many cases minimal history is available and both external and internal examination could fail to reveal any specific signs of bee sting or other obvious morphologic abnormalities. Thus, there is a need for reliable confirmatory or supportive diagnostic tests.
Tipo de publica??o: CASE REPORTS; JOURNAL ARTICLE
Nome de subst?ncia:0 (Antibodies); 0 (Bee Venoms);
(Immunoglobulin E); EC 3.4.21.59 (Tryptases)
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Autor:Radheshi E; Reggiani Bonetti L; Confortini A; Silingardi E; Palmiere CEndere?o:Department of Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia - Section of Medicina Legale, Modena, Italy.
Título:Postmortem diagnosis of anaphylaxis in presence of decompositional changes.
Fonte:J Forensic Leg M 38:97-100, 2016 Feb.
ISSN:País de publica??o:England
Idioma:engResumo:Eosinophil and activated mast cell identification in the spleen combined with mast cell tryptase determination in postmortem serum may diagnose fatal anaphylaxis with a high degree of certainty. Mast cell tryptase measurement and significance in corpses with decompositional changes remains however an issue of controversy. Analogously, immunohistochemistry in corpses with decompositional changes may be influenced by several mechanisms, including protein alteration, antigen diffusion and unspecific antibody binding to disrupted protein structures. The authors present an autopsy case involving a 55-year-old woman who unintentionally received clarithromycin. Due to difficult in administrative procedures, the postmortem examination was performed 96 h after death. Mast cell tryptase was measured in postmortem serum from femoral, aortic and right heart blood. The obtained results were consistent with mast cell activation. Histochemistry (Pagoda Red) and immunohistochemistry (anti-tryptase antibodies) allowed splenic eosinophils and mast cells to be detected. Based on the results of all postmortem investigations, the hypothesis of anaphylaxis following accidental clarithromycin administration was formulated.
Tipo de publica??o: CASE REPORTS; JOURNAL ARTICLE
Nome de subst?ncia:0 (Anti-Bacterial Agents); EC 3.4.21.59 (Tryptases); H1250JIK0A (Clarithromycin)
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