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FOXP3相互作用新分子C22orf37的克隆表达纯化及其抗体制备硕士论文.pdf66页
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国际十进分类号（UDC ）
第四军医大学
FOXP3相互作用新分子--C22orf37 的克隆表
FOXP3相互作用新分子--C22orf37 的克隆表
FFOOXXPP33相相互互作作用用新新分分子子----CC2222oorrff3377的的克克隆隆表表
达纯化及其抗体制备
达纯化及其抗体制备
达达纯纯化化及及其其抗抗体体制制备备
（作者姓名）
张英起 教授
指导教师姓名
第四军医大学药学系生物制药教研室
指导教师单位
生化与分子生物学
申请学位级别
论文提交日期
论文起止时间
第四军医大学
学位授予单位
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正在加载中，请稍后...Coordinated regulation of iron-controlling genes, H-ferritin and IR...
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1999 Jan 29;283(.Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.1, , .1Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. an.AbstractThe protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.PMID: 9924025
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External link. Please review our .Iron deficiency alters H- and L-ferritin expression in rat brain.
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):517-28.Iron deficiency alters H- and L-ferritin expression in rat brain.1, , , , .1Department of Nutrition, The Pennsylvania State University, University Park 16802, USA. its@psu.eduAbstractFerritin (Ft) H and L subunits are independently regulated proteins with both transcriptional and translational regulation in response to cellular iron levels. While the heterogeneous distribution of ferritin and iron in the brain is now well established, the relative response of each subunit to iron deficiency and iron supplementation, is not well defined. Weanling male Sprague-Dawley rats (n=12 per group) were randomly assigned to an iron deficient (3.5 mg Fe/kg diet), control (35 mg Fe/kg diet) or supplemented (350 mg Fe/kg diet) diet for six weeks. The H-/L-ferritin subunit ratio and mRNA levels were determined. Overall, the protein ratio in control rats of H to L was approximately 45:1 compared to a ratio &60:1 in iron deficiency but the absolute amounts of each subunit varied greatly from one brain region to another. The ratio of H-:L-ferritin mRNA was 6:1 and was not affected by dietary iron deficiency in contrast to a potent effect on mRNA levels in liver. Severe iron deficiency reduced brain ferritin H protein levels significantly in all regions, whereas only ferritin L levels in striatum, substantia nigra and pons were affected by iron deficiency. Supplemental dietary iron increased both ferritin subunits, with the largest increase (50%) in the hippocampus. These data indicate that ferritin H and L subunits within the brain respond differently to iron status and suggest post transcription regulation as a key event.PMID:
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External link. Please review our .H-ferritin overexpression promotes radiation-induced leukemia/lymph...
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):2269-75. doi: 10.1093/carcin/bgs251. Epub
2012 Jul 27.H-ferritin overexpression promotes radiation-induced leukemia/lymphoma in mice.1, , , , , , , , , .1Molecular Imaging Center, National Institute of Radiological Sciences,
Chiba 263-8555, Japan.AbstractH-ferritin (HF) is a core subunit of the iron storage protein ferritin and is related to the pathogenesis of malignant diseases. HF overexpression is present in human hematologic malignancies, suggesting that HF overexpression may contribute to the development of hematologic cancers. However, in vivo evidence that HF is directly linked to hematologic tumorigenesis has not yet been shown. In this study, we show that transgenic (tg) mice overexpressing the human HF gene (hHF-tg) developed aggressive radiation-induced thymic lymphoma/leukemia (TL) compared with wild-type (WT) mice, providing evidence that HF overexpression promotes leukemia/lymphomagenesis. Fractionated X-irradiation of hHF-tg mice caused a higher incidence and earlier onset of TL compared with WT mice. Immunological and pathological features of TLs were similar in both groups. However, proliferative activity of hHF-tg lymphoma cells was higher than that of WT lymphoma cells, and microarray analyses revealed that some leukemia/lymphoma-related genes were differentially expressed in hHF-tg TLs compared with WT TLs. To investigate whether cell damage induced by irradiation is related to leukemia/lymphomagenesis, we evaluated apoptotic levels in the thymus and bone marrow (BM) of hHF-tg and WT groups after fractionated X-irradiation. Apoptosis was augmented in the hHF-tg BM, but not in the thymus, compared with the WT BM, suggesting a possible linkage between increased BM apoptosis by HF overexpression and accelerated radiation-induced TL development. Our findings indicate that HF overexpression is closely related to the development of leukemia/lymphoma, which could have implications for the prevention of malignant hematologic diseases.PMID:
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External link. Please review our .ferritin是什么意思，词典释义与在线翻译：
提示：各行业词典APP中含有本词条的独家正版内容，在手机上可看到更多释义内容。
ferritin 在《外教社药学英语词典》APP的缩略释义：
ferritin 在《外教社医学英语词典》APP的缩略释义：
a protein containing 20% iron that is found in the intestines
it is one of the chief forms in which iron is stored in the body
ferritin的用法和样例：
用作名词 (n.)
Ferritin, one of the storage forms of iron, is brown, iron-containing protein.
铁的贮存形式之一的铁蛋白，是一种棕色含铁蛋白质。
铁蛋白标记抗体...
铁蛋白标记抗体...
铁蛋白结合抗体...
铁蛋白标记
ferritin的海词问答与网友补充：
ferritin的相关资料：
ferritin 在《医学英语词典》APP的缩略释义：
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