KEGG ENZYME: 6.3.5.4
&&&ENZYME: 6.3.5.4
EC&6.3.5.4&&&&&&&&&&&&&&&&&&Enzyme&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&
asparagine synthase (glutamine-hydrolysing);
asparagine synthetase (glutamine-hydrolysing);
glutamine-dependent a
asparagine synthetase B;
Forming carbon-
Carbon-nitrogen ligases with glutamine as amido-N-donor
L-aspartate:L-glutamine amido-ligase (AMP-forming)
Reaction(IUBMB)
ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate (overall reaction) [RN:];
(1a) L-glutamine + H2O = L-glutamate + NH3 [RN:];
(1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine [RN:]
Reaction(KEGG)
ATP [CPD:];
L-aspartate [CPD:];
L-glutamine [CPD:];
H2O [CPD:];
NH3 [CPD:]
AMP [CPD:];
diphosphate [CPD:];
L-asparagine [CPD:];
L-glutamate [CPD:];
NH3 [CPD:]
The enzyme from Escherichia coli has two active sites [4] that are connected by an intramolecular ammonia tunnel [5,6]. The enzyme catalyses three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain. The C-terminal active site mediates both the synthesis of a beta-aspartyl-AMP intermediate and its subsequent reaction with ammonia. The ammonia released is channeled to the other active site to yield asparagine [6].
EC 6.3.5.4 created 1972, modified 2006
&&Alanine, aspartate and glutamate metabolism&&Metabolic pathways&&Biosynthesis of secondary metabolites
&&asparagine synthase (glutamine-hydrolysing)
HSA:&(ASNS)PTR:&(ASNS) (ASNS)PPS:&(ASNS)GGO:&(ASNS)PON:&(ASNS)NLE:&(ASNS)MCC:&(ASNS)MCF:&(ASNS)CSAB:&(ASNS)RRO:&(ASNS)RBB:&(ASNS)CJC:&(ASNS)SBQ:&(ASNS)MMU:&(Asns)RNO:&(Asns)CGE:&(Asns)NGI:&(Asns)HGL:&(Asns)CCAN:&(Asns)OCU:&(ASNS)TUP:&(ASNS)CFA:&(ASNS)AML:&(ASNS)UMR:&(ASNS)ORO:&(ASNS)FCA:&(ASNS)PTG:&(ASNS)AJU:&(ASNS)BTA:&(ASNS)BOM:&(ASNS)BIU:&(ASNS)CHX:&(ASNS)OAS:& (ASNS)SSC:&(ASNS)CFR:&(ASNS)CDK:&(ASNS)BACU:&(ASNS)LVE:&(ASNS)ECB:&(ASNS)EPZ:&(ASNS)EAI:&(ASNS)MYB:&(ASNS)MYD:&(ASNS)HAI:& (ASNS)RSS:& (ASNS)PALE:&(ASNS)LAV:&(ASNS)TMU:&MDO:&(ASNS)SHR:&(ASNS)OAA:&GGA:&(ASNS)MGP:&(ASNS)CJO:&(ASNS)APLA:&(ASNS)ACYG:&(ASNS)TGU:&(ASNS)GFR:&(ASNS)FAB:&(ASNS)PHI:&(ASNS)PMAJ:&(ASNS)CCW:&(ASNS)FPG:&(ASNS)FCH:&(ASNS)CLV:&(ASNS)EGZ:&(ASNS)AAM:&(ASNS)ASN:&(ASNS)AMJ:&(ASNS)PSS:&(ASNS)CMY:&(ASNS)CPIC:&(ASNS)ACS:&(asns)PVT:&(ASNS)PBI:&(ASNS)GJA:&(ASNS)XLA:&(asns.L)XTR:&(asns)NPR:&(ASNS)DRE:&(asns)SRX:& SANH:& SGH:& (asns)CCAR:&
(asns)IPU:&(asns)AMEX:&
TRU:&(asns) TNG:& LCO:&(asns) NCC:& MZE:&(asns)OLA:&(asns)XMA:&(asns) PRET:&(asns)NFU:&(asns)CSEM:&(asns)LCF:&(asns)HCQ:&(asns)BPEC:&(asns)SASA:&(asns) ELS:&(asns)SFM:&(asns)CMK:&(asns)BFO:&
CIN:&SPU:&APLC:& SKO:&DME:&(AsnS)DPO:&DAN:&DER:&DPE:&DSE:&DSI:&(Dsim_GD14936)DWI:& DYA:& DGR:& DMO:& DVI:& MDE:& AGA:&AAG:&CQU:& AME:&(asparagine-synthetase)BIM:&BTER:&AEC:&ACEP:&PBAR:&HST:&CFO:&LHU:&PGC:&NVI:&TCA:&DPA:&NVL:&BMOR:&DPL:&PMAC:&PRAP:&PXY:&API:&DNX:&PHU:&ZNE:&FCD:&TUT:&CEL:&(asns-1) (asns-2)CBR:&(Cbr-nrs-2) NAI:&
LGI:& CRG:&MYI:&
EPA:&ADF:&HMG:&ATH:&(ASN1) (ASN3) (ASN2)ALY:&
CIT:& CIC:& TCC:& GRA:&
EGR:& GMX:&
(AS2) (AS1) (SAS3)PVU:&
LJA:&(Lj0g3v) (Lj0g3v) (Lj0g3v) (Lj0g3v) (Lj0g3v) (Lj0g3v) (Lj2g3v)LANG:&
FVE:& PPER:& PMUM:& PAVI:& MDM:&
ZJU:& CSV:&
MCHA:& CMAX:&
RCU:& JCU:& HBR:&
POP:&(POPTRDRAFT_829702) (POPTRDRAFT_207428) (POPTRDRAFT_722643)JRE:&
VVI:&SLY:& (LEAS1)SPEN:& SOT:&(ASN1) CANN:& (AS1)NTA:&
SIND:& OEU:&
OSA:& DOSA:&(Os03g0291500) (Os06g0265000)OBR:& BDI:&
ATS:&(LOC) (LOC) (LOC) (LOC) (LOC)SBI:&
ZMA:&(asn2) (asn3) (asn4)
(asn1)SITA:&
ATR:& SMO:& PPP:&
CRE:& VCN:&MNG:&OLU:&OTA:&BPG:&MIS:&(ASN2)MPP:&(ASN2)CSL:&CVR:&APRO:&CME:&GSL:&CCP:&SCE:&(ASN2) (ASN1)AGO:&ERC:&KLA:&LTH:&VPO:&ZRO:&CGR:&NCS:&(NCAS0F03510)NDI:&(NDAI0B05810)TPF:&(TPHA0D04200)TBL:&(TBLA0C04430)TDL:&(TDEL0D05520)KAF:&(KAFR0G03670)PPA:&DHA:&PIC:&(ASN1)PGU:&SPAA:&(ASN1)LEL:&CAL:&(ASN1)CTP:&COT:&CDU:&CTEN:&YLI:&CLU:&CLUS:&CAUR:&NCR:&NTE:&(NEUTE1DRAFT_119472)SMP:&PAN:& TTT:& MTM:& CTHR:&MGR:& TMN:&FGR:& FPU:& FVR:&FOX:&NHE:&TRE:&(asn1)MAW:&MAJ:& CMT:& PLJ:&VAL:&VDA:&CFJ:&
ELA:&PFY:&
SSL:&BFU:&MBE:&PSCO:&GLZ:&ANI:& AFM:&AOR:&ANG:&(An12g07660) (An04g01340)AFV:&
ACT:& NFI:&PCS:& PDP:&CIM:&CPW:&PBL:& PBN:& URE:&ABE:&TVE:&AJE:& PNO:& PTE:& BZE:& BSC:& BOR:& ZTR:&PFJ:&BCOM:& NPA:& TML:&SPO:&(asn1)CNE:&CNB:&CGI:&TMS:&TVS:&DSQ:&PCO:&SHS:& HIR:&PSQ:&ADL:&FME:&GTR:&LBC:&MPR:&
CCI:&SCM:&ABP:&(AGABI1DRAFT_68665)ABV:&(AGABI2DRAFT_190553)CPUT:&SLA:& WSE:&WIC:&UMA:&PFP:&MGL:&PGR:&MLR:&DDI:&(asnB) (asns)DPP:&
DFA:&(asns)ACAN:&PFA:&PFH:& PYO:&PCB:&(PC.0)PBE:&
PKN:&PVX:&PCY:&TGO:&TET:&PTM:&
SMIN:&(symbB.v1.2.) (symbB.v1.2.) (symbB.v1.2.)PTI:&FCY:&
TPS:&(ANS1)AAF:& (AS)PIF:&PSOJ:&SPAR:&
NGR:&ECO:&(asnB)ECJ:&(asnB)ECD:&(asnB)EBW:&(asnB)ECOK:&(asnB)ECE:&(asnB)ECS:&(asnB)ECF:&(asnB)ETW:&(asnB)ELX:&(asnB)EOJ:&(asnB)EOI:&(asnB)EOH:&(asnB)ECG:&(asnB)EOK:&(asnB)ELR:&(asnB)ECC:&(asnB)ECP:&ECI:&(asnB)ECV:&(asnB)ECX:&(asnB)ECW:&(asnB)ECM:&(asnB)ECY:&ECR:&(asnB)ECQ:&(asnB)ECK:&(asnB)ECT:&(asnB)EOC:&(asnB)EUM:&(asnB)ECZ:&(asnB)ELO:&(asnB)ELN:&(asnB)ELH:&ESE:&ESO:&(asnB)ESM:&(asnB)ESL:&(asnB)ECL:&EBR:&(asnB)EBD:&EKO:&EKF:&(asnB)EAB:&(asnB)EDH:&EDJ:&(asnB)EIH:&(asnB)ENA:&(asnB)ELU:&(asnB)EUN:&(asnB)ELW:&(asnB)ELL:&(asnB)ELC:&(asnB)ELD:&(asnB)ELP:&(asnB)EBL:&(asnB)EBE:&(asnB)ELF:&(asnB)ECOA:&(asnB)ECOL:&(asnB)ECOI:&(asnB)ECOJ:&(asnB)ECOO:&(asnB)ECOH:&(asnB)ECOS:&(asnB)EFE:&(asnB)EAL:&(asnB)STY:&(asnB)STT:&(asnB)SEX:&SENT:&(asnB)STM:&(asnB)SEO:&(asnB)SEV:&SEY:&(asnB)SEM:&(asnB)SEJ:&(asnB)SEB:&(asnB)SEF:&(asnB)SETU:&(asnB)SETC:&(asnB)SENR:&(asnB)SEND:&(asnB)SENI:&(asnB)SEEN:&(asnB)SEK:&(asnB)SPQ:&SEI:&(asnB)SEC:&(asnB)SEH:&(asnB)SHB:&SENH:&(asnB)SEEH:&(asnB)SEE:&(asnB)SENN:&SEW:&(asnB)SEA:&(asnB)SENS:&(asnB)SED:&(asnB)SEG:&(asnB)SEL:&(asnB)SEGA:&(asnB)SET:&(asnB)SENA:&(asnB)SENO:&(asnB)SENV:&(asnB)SENQ:&(asnB)SENL:&(asnB)SENJ:&(asnB)SEEC:&(asnB)SEEB:&(asnB)SENB:&(asnB)SENE:&(asnB)SENC:&(asnB)SES:&SBG:&(asnB)SBZ:&SBV:&(asnB)SFL:&(asnB)SFX:&(asnB)SFV:&(asnB)SFE:&(asnB)SFN:& SFS:&SFT:&(asnB)SSN:&(asnB)SBO:&(asnB)SBC:&(asnB)SDY:&(asnB)SDZ:&SHQ:&(asnB)ENT:&ENC:&ENO:&(asnB)ECLO:&EEC:&(asnB)ENL:&(asnB)ECLG:&ECLE:&(asnB)ECLN:&(asnB)ECLI:&(asnB)ECLX:&(asnB)ECLY:&(asnB)ECLZ:&(asnB)ECLA:&(asnB)ECLC:&(asnB)EAS:&EAU:&(asnB)EHM:&(asnB)EKB:&(asnB)ELG:&(asnB)EXF:&(asnB)ECLS:&(asnB)ENR:&(asnB)ENX:&(asnB)ENF:&ESA:&CSK:&(asnB)CSZ:&(asnB)CSI:&CSJ:&CCON:&(asnB)CDM:&(asnB)CMJ:&(asnB)CUI:&(asnB)CMW:&(asnB)CTU:&(asnB)KPN:&(asnB)KPU:&(asnB)KPM:&KPP:&KPK:&(asnB)KPH:&(asnB)KPZ:&(asnB)KPV:&(asnB)KPW:&(asnB)KPY:&(asnB)KPG:&(asnB)KPC:&(asnB)KPQ:&(asnB)KPT:&(asnB)KPE:&(asnB)KPO:&(asnB)KPR:&(asnB)KPJ:&KPI:&(asnB)KPA:&KPS:&KPX:&(asnB)KPB:&(asnB)KPNE:&(asnB)KPNU:&(asnB)KVA:&KVD:&(asnB)KVQ:&(asnB)KOX:&(asnB)KOE:&KOY:&(asnB)KMI:&(asnB)KOK:&(asnB)KOC:&(asnB)KOM:&(asnB)KQU:&(asnB)EAE:&(asnB)EAR:&KQV:&(asnB)CKO:&CRO:&(asnB)CFD:&(asnB)CBRA:&(asnB)CWE:&(asnB)CAMA:&(asnB)CAF:&(asnB)CIF:&(asnB)CFAR:&(asnB)GQU:&(asnB)HDE:&(asnB)EBT:&(asnB)ROR:&(asnB)RON:&(asnB)CNT:&(asnB)CEM:&(asnB)CEN:&(asnB)CED:&(asnB)PGE:&(asnB)ESC:&KLE:&(asnB)KSA:&(asnB)KOR:&(asnB)KRD:&(asnB)KCO:&(asnB)KIN:&(asnB)LAX:&(asnB)LAZ:&(asnB)LEF:&EBF:&PSTS:&YPE:&(asnB)YPK:&(asnB)YPA:&YPN:&YPM:&(asnB)YPP:&YPG:&(asnB)YPZ:&(asnB)YPT:&(asnB)YPD:&(asnB)YPX:&(asnB)YPH:&(asnB)YPW:&(asnB)YPJ:&(asnB)YPV:&(asnB)YPL:&(asnB)YPS:&(asnB)YPO:&(asnB)YPI:&(asnB)YPY:&YPB:&YPQ:&(asnB)YPU:&(asnB)YPR:&(asnB)YPC:&(asnB)YPF:&(asnB)YEN:&(asnB)YEP:&YEY:&YEL:&(asnB)YEW:&(asnB)YET:&(asnB)YEF:&YEE:&(asnB)YSI:&(asnB)YAL:&(asnB)YFR:&(asnB)YIN:&(asnB)YKR:&(asnB)YRO:&(asnB)YRU:&(asnB)YRB:&(asnB)YAK:&(asnB)SPE:& SRR:&SRL:&(asnB)SRY:&(asnB)SPLY:&(asnB_1) (asnB_2)SRS:&SRA:&SMAF:&SMW:&(asnB)SMAR:&(asnB)SMAC:&(asnB)SLQ:&(asnB)SERF:&(asnB)SERS:&(asnB)SFW:&(asnB)SFG:&(asnB)SRZ:&SFO:&(asnB)RAH:&RAQ:&RAA:&(asnB)ECA:&(asnB)PATR:&(asnB)PATO:&(asnB)PCT:&PCC:&PCV:&(asnB)PWA:&PPAR:&(asnB)PEC:&PWS:&(asnB)PPOA:&(asnB)SGL:&SOD:&(asnB)PES:&(asnB)DDA:&DZE:&DDC:&DZC:&(asnB)DSO:&(asnB)DDQ:&BGJ:&(asnB)ETA:&(asnB)EPY:&(asn) (asnB)EPR:&(asnB) (asnB)EAM:&(asnB) (asnB2)EAY:& (asnB)EBI:&(asnB)ERJ:&(asnB)EGE:&(asnB)WBR:&WGL:&(asnB)PAM:&(asnB)PLF:& (asnB)PAJ:&(asnB) (oxyD)PAQ:&
PVA:&(asnB) (asnB)PAO:&KLN:&(asnB)PANT:&(asnB)PANP:&(asnB)HHS:&(asnB) (asnB)PCK:&PAGG:&(asnB)PAGC:&(asnB) PSTW:&(asnB)PALH:&(asnB)TCI:&(asnB)PLU:&PAY:&(wbmC) (wbfR)PMIB:&XBO:&
XNE:&XNM:&EIC:&ETR:&(asnB)ETD:&ETE:&(asnB)ETC:&(asnB)EDW:&(asnB)EDL:&(asnB)EHO:&(asnB)HAV:&(asnB)PFQ:&(asnB)PSHI:&(asnB)GAN:&XFA:&XFT:&(asnB)XFM:&XFN:&XFF:&(asnB)XFL:&(asnB)XFS:&(asnB)XFH:&(asnB)XCC:&(asnB) (wbpS)XCB:& XCA:&(asnB2) (asnB1)XCP:&(asnB) (asnB)XCV:&(asnB) (asnB2) XAC:&(asnB) (asn) (asnB) XCI:& (asnB) (asnB) (asnB) (asnB) (asnB)XCT:&
XFU:&(wbqG) (asnB)XAX:&(asnB) XAO:&
(asnB) XOO:&(AsnB) (asnB)XOM:&(XOO1412) (XOO1881)XOP:&(asnB) (asnB)XOY:&(asnB) XOR:&(asnB) (asnB)XOZ:&(asnB) XAL:&(asnB)XSA:&(asnB) XTN:&(asnB)XFR:&(asnB) XGA:&(asnB)
XVE:& (asnB) XPE:& (asnB)XHR:& (asnB) XPH:&(XppCFBP) (asnB)SML:& (asnB) SMT:&
SMZ:& (asnB) (asnB2)SACZ:& (asnB) (stcC)STEK:&(asnB)SRH:& SLM:& (asnB)STEN:&(asnB) (asnB) (asnB)PSU:& PSUW:&(asnB)PSD:&(asnB)LAB:&(asnB) (asnB)LAQ:&(asnB) (asnB)LCP:&(asnB)LGU:& (asnB) (asnB)LEZ:&(asnB)
LUM:&(asnB)SNJ:&FAU:&RHD:&
DJI:&(asnB) DJA:& (asnB)DTX:&
DKO:&LRZ:& (asnB)VCH:&(asnB)VCF:&(asnB)VCE:&(asnB)VCJ:&VCO:&(asnB)VCR:&(asnB)VCM:&(asnB)VCI:&(asnB)VCL:&VCQ:&(asnB)VCS:&VCX:&(asnB)VCZ:&(asnB)VVU:&(asnB)VVY:&VVM:&VVL:&(asnB)VPA:&(asnB)VPB:&VPK:&(asnB)VPF:&(asnB)VPH:&VHA:&VCA:&(asnB)VAG:& VEX:&VHR:&(asnB)VNA:&(asnB)VOW:&(asnB)VRO:&(asnB)VSP:&VEJ:&(asnB)VFU:&VNI:& (asnB)VAN:&LAG:&(asnB)VAU:&(asnB)VCY:&(asnB) VCT:&(asnB)VTU:&(asnB)VFL:&(asnB) (asnB)VMI:&(asnB)VBR:&(asnB)VSC:&(asnB)VGA:&(asnB)VSH:&
(asnB)VQI:&(asnB)VFI:&(asnB)VFM:&(asnB)VSA:&(asnB)AWD:&(asnB)PPR:&(Y1198)PGB:&
PDS:&(asnB) GHO:&(asnB)PMAI:&(asnB)PAE:&(phzH)
PAEV:&(asnB) (asnB) (asnB)PAEI:&(asnB) (asnB) (asnB)PAU:&(phzH) (asnB) (asnB)PAP:&(asnB)PAG:&(phzH)
PAF:&(phzH)
PNC:&(phzH) (asnB) (asnB)PAEB:&(phzH) (asnB) (asnB)PDK:&
PAEU:&(phzH)
PAEC:&(asnB) (asnB) (asnB)PAEO:&(asnB) (asnB) (asnB)PMY:&PMK:&
PRE:&(asnB)PPSE:&(asnB)PALC:&
PCQ:&(asnB)PPU:&(asnB)PPF:&PPG:&PPW:& PPT:&PPB:&(asnB)PPI:&PPX:&(asnB)PPUH:&PPUT:&PPUN:&(asnB)PPUD:&PFV:& PMON:&PMOT:&PMOS:& PPJ:&POR:&PST:&(asnB)PSB:& PSYR:&PSP:&(asnB)PCI:&PFL:&(asnB)PPRC:&(asnB)PPRO:&(asnB)PFO:&PFS:& PFE:&PFC:&(asnB)PFN:&PFW:& (asnB)PFB:&PFF:& PFX:& PPZ:&
PMAN:&PTV:& PCG:&PVR:&PAZO:&
PSA:&(asnB)PSZ:&(asnB)PSR:&(asnB-1) (asnB-2)PSC:&PSJ:& PSH:&PSTU:& PSTT:&PBM:&PBA:&PBC:&PPUU:&(asnB)PDR:&PSV:&
PSK:&PKC:&(asnB)PCH:&PCZ:&PFZ:&PRH:&PSW:&PPV:& PSES:& (asnB_2) PSEM:&PSEC:& PPSY:&PSOS:&(MGR_3523) (asnB) (asnB) (C380_07335)PKR:&PFK:&PANR:&PPSL:&AVN:&(asnB)AVL:&(asnB)AVD:&(asnB)ACX:&(asnB)PAR:&(asnB) (wbpS)PCR:&PRW:&PSO:&ABAB:&ABAL:&ASOL:&SON:&(asnB) (wbpQ)SDN:&
SFR:&SAZ:&SBL:&SBM:&SBN:&SBP:&SBT:&SBS:&SBB:&SLO:& SPC:&SHP:&SSE:&SPL:&SHE:&SHM:&SHN:&SHW:&SHL:&SWD:&SWP:&SVO:&(asnB)SHF:&(asnB) (asnB)SJA:&SPSW:&SBJ:&(asnB)ILO:&(asnB)ILI:&IPI:&(asnB)IDI:&(asnB)CPS:& (asnB)COM:&(asnB)
COZ:& (asnB)COLW:&(asnB)PHA:&(asnB)PAT:& PSM:&(asnB)PSEO:&(asnB) PIA:& PPHE:&
PBW:&(asnB)PRR:&(asnB)PTN:&(asnB) PLZ:&(asnB)PALN:&(asnB)PPIS:&(asnB)
(asnB)PEA:&(asnB)PSPO:&(asnB) (asnB)PART:&(asnB)PTU:&(asnB)MAQ:&MHC:&MAD:& MBS:&(asnB)MPQ:&MARI:&MLQ:&AMC:&(asnB) AMH:&(asnB)
AMAA:&(asnB)
AMAL:&(asnB) AMAE:&(asnB) AMAO:&(asnB) AMAD:&(asnB)
AMAI:&(asnB)
AMAG:&(asnB) AMAC:&(asnB)
AMB:&(asnB) AMG:&(asnB) AMK:&(asnB)ALT:&(asnB)AAL:&(asnB) AAUS:&(asnB) ASP:&ASQ:&(asnB)AAW:&(asnB)GAG:&
GNI:& GPS:&
PIN:& PSY:&(asnB)FBL:& MVS:&(asnB)CEB:&CELL:&SDE:&TTU:&(asnB)CBU:&(asnB-1) (asnB-2)CBS:&(asnB1) (asnB2)CBD:&(asnB2) (asnB1)CBG:&(asnB1) (asnB2)CBC:&(asnB1.1) (asnB1.2)CEY:&
(asnB1) LPN:&(wbmI)LPO:&(wbmI)LPU:&LPM:&(asnB2)LPC:&(wbmI)LPA:&(asnB)LPE:&LLO:& LFA:&LOK:&
LCD:&(asnB)MCA:&
MAH:& MPSY:& FTU:&(wbtH)FTQ:&(asnB)FTF:&(wbtH)FTW:&(wbtH)FTR:&FTT:&(wbtH)FTY:&FTG:&(wbtH)FTL:&FTH:&(asnB)FTA:&(wbtH)FTS:&FTI:&(wbtH)FTO:&FTC:&(asnB)FTV:&(asnB)FTZ:&(asnB)FTM:&(wbtH)FTN:&(asnB) (wbtH)FTX:& (asnB)FTD:&FCF:&FCN:& FPH:&FPI:&(asnB)FPX:&(asnB)FPJ:&FHI:& FHA:&(asnB)FRM:& TCX:&TCY:&TAO:& MEJ:&(asnB)TIG:&
BLEP:& NOC:&
TEE:& NTT:& TSY:&
HHA:&HHC:&
TNI:&(asnO_[H]) (asnB_[H])TTI:&
HNA:&HAZ:&WMA:& WOC:&
GAI:&(asnB_1) (asnB_2) (asnB_3) (asnB_4)HCH:&(asnB1) (asnB2) (asnB3) (asnB4) HCO:&(asnB)HALO:& KKO:&KGE:&KSD:&KPD:&(asnB)MME:&MARS:& GSN:&OME:&
AHA:&(asnB)AHY:&(asnB)AHD:&(asnB)AHR:&(asnB)AHP:&(asnB)AHJ:&(asnB)AHH:&(asnB) AHI:&(asnB)ASA:&(asnB)AVR:&AVO:&(asnB)AMED:&ASR:&(asnB)AAJ:&(asnB)AEO:&ADH:&(asnB)ACAV:&(asnB)TAU:&OCE:&(asnB)ZDF:&(asnB)GAP:&FPP:&SDF:&
SLIM:& TBN:&
TSN:&THO:& TTC:&
RMA:&VOK:&(asnB)EBH:&(asnB)ENM:&(asnB)CVI:& (asnB) CVC:&
CHRO:&(asnB)LHK:& PSE:&JEU:&AQL:&RPJ:&REU:&REH:&(h16_A3223)CNC:&(asnB)CGD:&BMA:&
(asnB)BMV:&(asnB) BML:&(asnB_1) (asnB_2) BMN:& (asnB_1) (asnB_2)BMAL:&(asnB) (asnB) (asnB)BMAE:&(asnB) (asnB) (asnB)BMAQ:&(asnB) (asnB) (asnB)BMAI:&
BMAF:&(asnB) (asnB) (asnB)BMAZ:&(asnB) (asnB) (asnB)BMAB:&(asnB) (asnB) (asnB)BPS:& (asnO) BPM:&(asnB) (asnB) (asnB)BPL:& (asnB) (asnB)BPD:& (asnB) (asnB)BPR:&(asnB_1)BPSE:&(asnB) (asnB) (asnB)BPSM:&(asnB) (asnB) (asnB) (asnB)BPSU:&(asnB) (asnB) (asnB) (asnB)BPSD:&(asnB) (asnB) (asnB)BPZ:& (asnO) BPQ:&
BPK:&(asnB) (asnB) (asnB)BPSH:&(asnB) (asnB) (asnB)BPSA:&(asnB) (asnB) (asnB)BPSO:&(asnB) (asnB) (asnB)BUT:&(asnB) (asnB) (asnB)BTE:&(asnB-1) (asnB-2)BTQ:&(asnB) (asnB)BTJ:&(asnB) (asnB)BTZ:&(asnB) (asnB)BTD:&(asnB) (asnB) (asnB) (asnB)BTV:&(asnB) (asnB)BTHE:&(asnB) (asnB)BTHM:&(asnB) (asnB)BTHA:& BTHL:&(asnB) (asnB)BOK:&(asnB) (asnB) (asnB)BOC:&(asnB) (asnB) (asnB)BVI:&BVE:&(asnB)BUR:&BCN:&BCH:&BCM:& BCJ:&BCEN:&(asnB)BCEW:&(asnB)BCEO:&BAM:&BAC:&BMU:&BMK:&(asnB) (asnB)BMUL:&(asnB)BCT:&BCED:&(asnB)BCEP:&BDL:&(asnB)BPYR:&BCON:& BUB:&(asnB)BDF:&BLAT:&BTEI:&BSEM:&BPSL:&BMEC:&BSTG:& BSTL:& BGP:&(asnB) (asnB)BGF:&BGD:&BGO:&(asnB) (asnB)BYI:&BUK:&BUE:&BUL:&(asnB) (asnB) (asnB) (asnB)BPLA:&
BRH:& BCAI:&PARA:& PPUL:&PSPU:&PVE:&POX:&PTX:& PNR:&BPE:&BPC:&BPER:&BPET:&BPEU:&BPA:& (wbmI) (wbmC) BPAR:& (wbmC) BBR:& (wbmI) (wbmC) BBM:&(wbmI) (wbmCC) (wbmC) BBH:& (wbmC) (wbmI) BBX:& (wbmI) (wbmC) BPT:&(asnB) (wbpS)BAV:&(wbpS)BHO:& BHM:& BHZ:&(asnB_1) (asnB_2) (asnB_3) (asnB_4)BTRM:&(wbpS)BPDZ:&
AXY:&(asnB)AXO:&AXN:&
AXX:&(asnB_1) (asnB_2) (asnB_3)ADT:&TEQ:&TEA:&TEG:&PUT:& AKA:&AMIM:&CDN:&AFA:&ODI:& RFR:&
RHY:& POL:&PNA:&AAV:& AAA:&
ACK:&ACID:&ACIP:&ACIN:&ACIS:&VEI:&ADN:&ADK:&RTA:&CBX:&(asnB-1) (asnB-2)LIH:&(asnB)HYR:&(asnB)HYB:&
HYL:& MPT:&JAG:&(asnB)
(asnB)JAZ:& JAL:& JSV:& HSE:&(asnB) (asnB) (asnB) (asnB)HSZ:&
MNR:& MASW:&MASS:& LCH:&TIN:&
THI:& RGE:&(asnB)
RDP:& PKT:&
MIU:&RGU:&BBAG:&
PBH:&(asnB)NEU:&(asnB) NET:&
NMU:& NLC:&
SHD:&METR:&
(asnB) (asnB)TBD:&
MMB:&SLT:&GCA:& SDR:&
EBA:&(asnB)
(asnB)DAR:&
AZO:&(asn) (asnB1) (asnB2)AZA:& (asnB)AZI:&
TCL:&THK:& APP:&
BEB:& HCP:&HTY:& WSU:&(WBPS) (glmS) (WBFR) (PAB1605)TDN:&
SUA:&SKU:& SULR:&CFF:&(asnB) (asnB)CFT:& CFV:& CFX:& CFZ:& CAMP:& CFP:& CCO:& CAJ:&
ABU:&(asnB1) (asnB2) (asnB)ABT:&ABL:&(asnB)ANT:&
ARC:&ALP:&SDL:&SBA:&
SHAL:&NSA:&NIS:& SUN:&NAM:&(asnB)GSU:&(asnB)GSK:&(asnB)GME:&(asnB-2) (asnB-1)GUR:& GLO:&GBM:&(asnB-3) (asnB-4) (asnB-5)GEO:&GEM:& GEB:&
GPI:& GAO:&PPD:&
PACE:& PEF:&DEU:&DVU:& DVL:& DVG:& DDE:&
DDS:&DMA:& DSA:& DAF:& DHY:&
DGG:& (asn) (asnB)DFI:& DPG:&DEF:&(asnB)DAS:&
DEJ:&LIP:&(asnB)LIR:&(asnB)DBA:&
DPS:&DAK:&
DPR:&DSF:&
DOL:& DML:&(asnB)DAT:&(asnB)DTO:&(asnB)ADE:& ACP:&AFW:&ANK:&MXA:&MFU:&
MSD:& MYM:&MMAS:&
CCX:& (asnB) SUR:&
(asnB)MBD:&
VIN:& SCL:&(asnB1) (asnB2) (asnH) (asnB3)SCU:&
SAMY:& LLU:&
HOH:&SAT:& DAO:&
SFU:&DBR:&BMX:&(asnB)
BSTO:&PACA:&CAQ:&
NAF:& MLO:&
MOP:&MAM:&
MAMO:& MESO:&MESW:&
MES:& AAK:& PHT:&PLA:&SME:&(asnO) (asnB)SMK:&
SMX:&(asnB) (asnO)SMI:& (asnO)SMEG:&
SMEL:&(asnO) (asnB)SMER:& SMD:& RHI:& SFH:&(asnB) SFD:&(asnB1) (asnB2)SIX:&(asnB)SAME:& (asnB)SINO:& EAD:&EAH:&ESJ:& ARA:&(asnB)ATF:&(asnB)AGR:&AGC:&(asnB) (asnB) (asnB)RET:&(asnB)RLE:&RHT:& (asnB)NGL:&NGG:&SHZ:& OAN:&OAH:&(asnB)OCH:&(asnB)BJA:& (asnB)BJU:&
BRAD:&BIC:& BRO:&
RPC:& RPE:&RPT:&RPX:&OCA:&OCG:&OCO:&AZC:&MEX:& MEA:&MDI:&MCH:&MRD:&MET:&MPO:&MNO:&
META:&MAQU:&(asnB)MZA:&MOC:& CHEL:&CDQ:&HDN:& HDT:&HMC:&HNI:&
RVA:& FIL:&FIY:&DEQ:&
MSC:& MBRY:& MTW:&
(asnB)MEY:&MAAD:&MMED:&(asnO)AUA:&MCG:&
PSIN:&HDI:&(asnB)RBM:&
CAK:& CSE:&CMB:&(asnB) (asnB)PZU:&BRD:& BNE:&BRG:&BRL:& BVC:&AEX:& CBOT:&
RSP:&(asnB) RSH:&RSQ:&RSK:&RDE:&(asnO)RLI:&PDE:&PCON:&RED:&MALG:&CON:&PPHR:& LAP:&LAGG:&LABR:&AHT:&(asnO)HBC:&
NAR:& NPP:&
SAL:&SPHK:&
SGI:& (asnB) (asnB2) SPHL:&SPHQ:&
SWI:& STAX:& SPHI:&
SSAN:& SMY:& SPAN:&
SPLM:& SPLK:&SPHJ:&SPHD:&
SJP:&(asnB) SCH:& SSY:& (asnB) SYB:& SBD:& SPMI:&SPHB:&(asnB) SPHR:&
(asnB)SINB:&SPHT:&
SHYD:& SYA:&
CIJ:& SPHG:&SFLA:&(asnO) (asnB) (asnO)BLAS:&(asnB) (asnB) RDI:&ELI:& ELQ:&ERY:& EGN:&
EFV:&AAY:&(asnB) (asnO)AMX:&AEP:& ANH:& (asnB)ADO:& (asnB)CNA:&
CMAN:& PNS:&PORL:&GOX:&GOH:&GOY:&(asnB)GAL:&GBE:&GBH:&GBC:&GBS:&ACR:&AMV:&(asnB) GDI:&GDJ:&GXL:&KEU:&(asnB)APT:&APW:&APF:&APU:&APG:&APQ:&APX:&APZ:&APK:&ASZ:&ASV:&APER:&APOM:&(asnB)ATO:&(asnB)ABG:&KBA:&RGI:&ROS:&(asnB)NCH:&RRU:&
RCE:&(asnB) (asnB) (asnB)RPM:&MAG:&
(asnB)MAGX:&
AZL:&(asnB)ALI:&(asnB2) (asnB1) ABS:&(asnB) (asnB)ABQ:&
TMO:&(asnB) (asnO) (asnB) (asnO) (asnB) (asnH)
(asnO) (asnO) (asnO)TXI:& THAC:&(asnB)
(asnB)MAGQ:&(asnB)
NAO:&(asnB)PBR:&MGM:&
MAI:& MAN:& PGV:&APC:& APM:&APB:&AFR:&(asnB)ACU:&BSU:&(asnO) (asnB) (asnH)BSR:&(asnO) (asnB)BSL:& BSH:&(asnO) (asnB) (asnH)BSY:& BSUT:&(asnO) (asnB) (asnH)BSUL:&(asnO) (asnB) (asnH)BSUS:& BSS:&(asnO) (asnB)BST:&(asnO) (asnB)BSO:&(asnO) (asnB)BSN:& BSQ:&(asnO) (asnB) (asnH)BSX:&(asnO)BSP:&
BLI:&(asnB) (asnO)BLD:&(asnO) (asnB) BLH:&(asnO) (asnB) BAY:&(asnO) (asnB)BAQ:&(asnB) (ansB5)BYA:&(asnO) (ansB5)BAMP:& BAML:&(asnO) (asnB)BAMA:&(asnO) (asnB)BAMN:&(asnO) (asnB)BAMB:&(asnB) BAMT:& BAMY:&(asnO) (asnB)BMP:&(asnO) (asnB)BAO:&(asnO) (asnB)BAZ:&(asnO) (asnB)BQL:&(asnO) (asnB)BXH:&(asnO) (asnB)BQY:&(asnO) (asnB)BAMI:& BAMC:& BAMF:& BAE:& BATR:& BVM:& BHA:&BAN:&(asnO1) (asnO2) (asnO3)BAR:&(asnO1) (asnO2) (asnO3)BAT:&
BAH:&(asnO3) (asnO2) (asnO1)BAI:&(asnO1) (asnO2) (asnO3)BAX:&
BANV:& (asnB) (asnB)BCE:& BCA:&(asnO) (asnO) (asnO)BCZ:&(asnO) (asnO) (asnB)BCR:&(asnO1) (asnB) (asnO3)BCB:&(asnO1) (asnO2) (asnO3)BCU:&(asnO1) (asnO2) (asnO) (asnO3)BCG:&(asnO3) (asnO2) (asnO1)BCQ:&(asnO) (asnO) (asnB)BCX:&(asnO1) (asnO2) (asnO3)BAL:& (asnO1) (asnO2) (asnB)BNC:&
BTK:&(asnO) (asnO) (asnB)BTL:&
BTB:&(asnO1) (asnO2) (asnO3)BTT:&
BTC:&(asnO1) (asnO2) (asnO3)BTF:&
BTG:&(asnO1) (asnO2) (asnB)BTI:&
BTW:&(asnB) (asnB) (asnB)BTHY:&
BWW:&(asnB1) (asnB3) (asnB2)BMYC:& (asnB) (asnB)BMYO:&(asnB) (asnB) (asnB) BTY:&
BCL:&(asnO) (asnB)BPU:& BPUM:& BPUS:& BPF:&(asnB) (asnO)BMQ:&(asnO)BMD:&(asnO) BMH:&(asnB) (asnO1)BMEG:&(asnB)BCO:&
BCK:&(ansB) BAG:& BCOA:&(asnB) (asnB)BJS:& BACI:&
BIF:& BLE:& BMET:&(asnO) (asnB)GST:&BACW:& BACP:& BACB:& BBY:&
BACY:& BACL:&(asnO) (asnB) (asnH)BALM:&
BSM:& BSJ:&
BGY:&(asnO) (asnB)BFX:& BGI:& BWH:& BXI:& BHK:&BKW:&(asnO) (asnB)BBEV:&(asnB)BKO:&(asnB)
(asnB)BALT:&(asnB) (asnB) (asnB)BACS:& OIH:&GKA:& (ansB)GTE:& GTK:& GTM:& GLI:& GTN:& GWC:& GYC:& GYA:& GCT:& GMC:& GGH:&(asnO) (asnB)GJF:& GEA:&(asnO) (asnB)GEL:&GSE:& GSR:& GEJ:& GTH:& PTL:& AFL:&(asnB) (asnO)AGN:& ANM:&(asnB) (asnB) (asnB)AAMY:&(asnB) (asnB) (asnB)ANL:&(asnB) (asnB) (asnB)AXL:&LSP:& LGY:& LFU:& HHD:&(asnO) (asnB)HMN:&
TAP:& VIR:& VHL:& VIG:& VIL:&
(asnB)VNE:& (asnB) VPN:&(asnO) (asnB)LAO:& FPN:& FAR:& SJE:& APAK:&
LMO:&(ansB)LMF:&(asnB)LMH:&(asnB)LMC:&(ansB)LMN:&(ansB)LMY:&(ansB)LMT:&LMG:&LMS:&LMJ:&LMQ:&(ansB)LML:&(asnB)LMP:&LMW:&(asnB)LMX:&(asnB)LMZ:&(asnB)LMON:&(asnB)LMOC:&(asnB)LMOS:&(asnB)LMOO:&(asnB)LMOY:&(asnB)LMOT:&(asnB)LMOA:&(asnB)LMOL:&(asnB)LMOG:&(asnB)LMOE:& LMOB:& LMOJ:&LMOZ:&LMOD:&(ansB)LMOW:&LMOX:&LMOQ:&(asnB)LMR:&(asnB)LMOK:&LMV:&LMOM:&LIN:&LWE:&(ansB)LSG:&(asnB)LIV:&(ansB)LII:&LIW:&LIA:&LIO:&BTHS:&(asnB)BBE:&(asnB) (asnO) BLR:&
BFM:& PJD:&GYM:&PPY:&
PPM:&(asnH) (asnB) (asnO)PPO:&(asnH) (asnB) (asnO)PPOL:& PPQ:&(asnB)
(asnO)PMQ:&
PTA:& PLV:&(asnO1) (asnO2) (asnB)PSAB:& PDU:&
PBD:& PGM:& POD:& PAEN:& PAEF:& PAEQ:& PSTE:&
PAEA:& PAEE:& PAEH:& PAEJ:& PBJ:&PIH:& PRI:& (asnO)PPEO:& PNP:&
POW:& PBV:&PXL:&
PYG:&PSWU:& PDH:&(asnB)PIB:& PCX:& PKB:& TCO:&
ANX:& ASOC:&(asnO)AAC:&AAD:&(asnB)BTS:& KYR:&(asnB) (asnB)TUM:& TAB:&(asnB) (asnB)SIV:&SSIL:&SOB:&(asnB)PMAR:&
PPLA:&JEO:& KUR:&(asnB)SPSY:&RST:&LLA:&(asnB) (asnH)LLK:&(asnB) (asnH)LLT:&(asnB) (asnH)LLS:&(asnB) (asnH)LLD:& LLX:&(asnB) (asnH)LLC:& LLM:&(asnB) (asnH)LLR:& LLN:&(asnB) LLI:&(asnB) (asnH)LLW:& LLJ:&(asnB) SPW:&SNM:&SNV:&SSU:&SSV:&SSS:&STJ:&LPL:&(asnB1) (asnB2)LPJ:&(asnB1) (asnB2)LPT:&(asnB1) (asnB2) LPS:&(asnB1) (asnB2)LPR:& LPZ:& LPB:& LJO:&LJF:&(asnB)LJH:&LJN:&LAC:&(asnH)LAI:&LAD:&LAF:&(asnH)LSA:&(asnB)LSL:&(asnB)LSI:&(asnB)LSJ:&(asnB)LDB:&(asnB1)LBU:&LDE:& (asnB)LDL:& LBR:&LBK:&LCA:&LPQ:&LPI:&LPAP:&LCB:&(asnH)LCZ:&LCS:&(asnB)LCE:&(asnB)LCW:&(asnB)LCL:&LCX:&LGA:&LRE:&LRF:&LRU:&(asnB)LRT:&LRR:&LHE:&LHL:&LHR:&LHV:&(asnH)LHH:&LHD:&LFE:& LFR:& LFF:&(asnB) LRH:&(asnB)LRG:&LRL:&(asnB)LRA:&(asnB) (asnB)LRO:&LRC:&LCR:&(asnB)LAM:&LAY:&LBH:&LBN:&(asnB)LKE:&(asnH)LRM:&(asnB) (asnB)LAW:&LHO:&(asnB) LMU:& LAE:&LGN:&LKO:&LHI:&LKU:&LGL:&LPX:&LOR:&
LPAR:&LLE:&LPD:&LJE:&LCU:&LCT:&LBT:&LCV:&LAH:&LAMY:&LAGL:& LZY:& LPG:& PPE:&PPEN:& PCE:&(asnB)PDM:& PACI:&EFQ:&EFC:&EFAU:&EFU:&(asnB)EFM:&EFT:&EHR:&ENE:&ECAS:&EMU:&(asnB)EDU:&EGA:&THL:&(asnB)VTE:&VPI:&ASAN:&CML:&(asnB)CARC:&CAC:&(asnB) CAE:&(asnO) (asnO)CAY:&(asnB) CBO:&CBA:&CBH:&CBK:&(asnB) CBI:&CBN:&CBT:&(asnB) CBE:&CBZ:&CBEI:& CKL:&(asnB) (asn)CKR:& CLJ:& (asn) (asnB)CCB:& CLS:&(AsnB)CLB:& CSR:&(asnO)CPAS:&CPAT:&(asnO)CPAE:&(asnO)CSB:&(asnO)
CLT:&(asnO) (asnB)CBV:&(asnB)CSQ:& CACE:&(asnO)CCK:& CBUT:& CTYK:& (asnB)CEU:& CTAE:& CFM:&CARG:&AMT:&ASF:&ASM:&(asnB)ASO:&(asnB)ASB:&(asnB)GFE:&CTH:&CTX:&RUK:&
CCL:&ESR:&ESU:&CSS:&(asnO)CSD:&CCEL:&(asnO)EHA:&RAL:&
RBR:& RCH:&RUS:&(asnH)RBP:&FPR:&FPA:&BPB:&(asnB1) (asnB2) (asnB3) (asnB4) (asnB5) (asnB6) (asnB7) (asnB8) (asnB9) BFI:&BHU:&
CLE:& RHO:&RIX:& RIM:& COO:&ROB:&BYL:&RTO:& BHAN:&(asnB) CPY:&LACY:&CSH:&CSO:& BPRL:&CPRO:&(asnB_1) (asnB_2) (asnO)ERE:&ERT:&ERA:&CDF:&(asnB) (asnB)PDC:&(asnB1) (asnB2)CDC:& (asnB)CDL:& (asnB)PDF:&(asnB) (asnB1)CST:&(asnB)PSOR:&STH:& SWO:&SLP:&DSY:&DHD:&DDH:&DDL:&DMT:&DRM:&DAE:&
DCA:&DKU:&DRU:&DGI:&DFG:&
PTH:&(AsnB)DAU:&TJR:&SGY:& DOR:& DAI:& DMI:&DED:&DEC:&DRS:&HMO:&(asnB)EEL:&OVA:&(asnO) (asnB)TMR:& SAY:&(asnB) (asnB)SAP:& IBU:&FPLA:&TTE:&(AsnB)TEX:& THX:& TPD:& TIT:& TMT:& TBO:& TWI:& TKI:&(asnO) (asnB)CHY:&(asnB)MTA:&TPZ:& (asnB)CSC:&ATE:&COB:&CHD:&COW:&CKI:&CKN:&CLC:&TOC:&TTM:& TTO:& TXY:&TSH:& MAS:&NTH:&
HOR:&AAR:&HHL:&PMIC:&SELT:&PUF:&PFT:& EUC:&TUR:&
FRO:&ERB:& LPIL:& POY:&(asnB)AYW:&MBP:&(asnB)AOC:&(asnB)MTU:&(asnB)MTV:&MTC:&MRA:&(asnB)MTF:&MTB:&MTK:&MTZ:&MTG:&MTE:&MTUR:&(asnB)MTL:&MTO:&(asnB)MTD:&(asnB)MTN:&(asnB)MTJ:&MTUB:&MTUC:&MTUE:&MTX:&MTUL:&MTUT:&(asnB)MTUU:&(asnB)MTQ:&(asnB)MBO:&(asnB)MBB:&(asnB)MBT:&(asnB)MBM:&(asnB)MBK:&MBX:&MBZ:&MAF:&(asnB)MCE:&(asnB)MCQ:&(asnB)MCV:&(asnB)MCX:&(asnB)MCZ:&(asnB)MMIC:&MLE:&(asnB)MLB:&(asnB)MPA:&(asnB) (asnB)MAO:& MAVI:& MAVU:& MAV:&(asnB) (asnB)MAVD:& MAVR:& MAVA:& MIT:& MIA:& MIE:& MIR:& MID:& MYO:& MCHI:& MMAL:&(asnB) MSM:&(asnB) (asnB)MSG:& (asnB)MSB:& MSN:& MSH:& MSA:&
MUL:&(asnB)MVA:& MGI:& MSP:& MAB:&MABB:&MMV:&MAY:&MABO:&MABL:&MAZ:&MAK:&MYS:&MYC:&MCHE:&MIZ:&
MSTE:&MMC:& MKM:& MJL:& MJD:&(asnB) MMI:&(asnB)MMAE:&(asnB)MRH:&
MMM:& MCB:&
MLI:&(asnB)MKN:&MKS:&MKI:&MNE:&
MYV:& MYE:& MGO:& MFT:& MHAD:&MPHL:&(asnB_1) (asnB_2)MVQ:&(asnB1) (asnB2)MYN:&
MLL:& MDX:& ASD:&CGL:&(Cgl2196)CGB:&(ltsA)CGU:&(LtsA)CGT:&CGS:&CGG:&CGM:&(ltsA)CGJ:&CGQ:&CGX:&CEF:&(ltsA)CDI:&(asnB)CDP:&(ltsA)CDH:&(ltsA)CDT:&(ltsA)CDE:&(ltsA)CDR:&(ltsA)CDA:&(ltsA)CDZ:&(ltsA)CDB:&(ltsA)CDS:&(ltsA)CDD:&(ltsA)CDW:&(ltsA)CDV:&(ltsA)CDIP:&(ltsA)CJK:&(asnB)CUR:&CUA:&(ltsA)CAR:&(ltsA)CKP:&CPU:&(asnB)CPL:&(asnB)CPG:&(asnB)CPP:&(asnB)CPK:&(asnB)CPQ:&(asnB)CPX:&(asnB)CPZ:&(asnB)COR:&(asnB)COP:&(asnB)COD:&(asnB)COS:&(asnB)COI:&(asnB)COE:&(asnB)COU:&(asnB)CPSE:&CPSU:&CPSF:&CRD:&(ltsA)CUL:&(asnB)CUC:&(asnB)CUE:&(asnB)CUN:&(asnB)CUS:&(asnB)CUQ:&(asnB)CUZ:&(asnB)CUJ:&(asnB)CVA:&(ltsA)CHN:&CCN:&CTER:&CMD:&CAZ:&CFN:&CCG:&CVT:&CGY:&CAX:&CII:& CUV:&COA:&(asnB)CDO:&CHM:&CSX:&(asnB)CMQ:&(asnB)CKU:&(asnB)CCJ:&(asnB)CMV:&(asnB)CEI:&(asnB)CTED:&(asnB)CUT:&(asnB)CLW:&CDX:&(asnB)CSP:&(asnB)CSTA:&CCJZ:&CFK:&CPHO:&CFC:&CGV:&(asnB)CSTR:&CAQU:&CSPH:&CAMG:&BFV:&NFA:&(ltsA) NFR:&(asnB_1) (asnB_2)NCY:& (asnB)NBR:&
NNO:&(asnB1) (asnB2) NSL:&
NSR:&(asnB) NTP:&(asnB) (asnB)
(asnB)RHA:&(asn1) (asn2)RER:&(ltsA)REY:&REB:&ROP:&(ltsA) (asnB)ROA:& REQ:&(asnB1) (asnB2)RPY:&RHB:&RAV:& RFA:&(asnB)RHW:&
RHS:&(asnB)RRZ:&(asnB)RHU:&(asnB)GBR:& GPO:&(asnB1) (asnB2) GOR:& GOQ:& GTA:& TPR:&TSM:&SRT:&DTM:& CBQ:&SCO:&(SCF62.12)SMA:& (mcjC1) (mcjC2)SGR:&SGB:&SCB:& SSX:&SVL:&
SCT:&(asnH) (asnO) (asnO)SCY:&
SFA:& SBH:&
SDV:& (asnH2) SALS:&
STRP:& SFI:&
SLV:&SGU:&
SVT:& STRE:&
SXI:& STRM:&
SPRI:& SCZ:&
SRW:&(asnO_1) (asnO_2) (asnO_3)
(TUE45_pSRTUE45c_0245) (asnB)STRF:&
SLE:&(ls3B) (sle_05810) (sle_29740) (sle_57470) (sle_62380) (sle_64640)SRN:&(asnB)
(asnO_2)SPAV:&SLC:&
SCLF:& SGS:&
SNW:&SAUO:& SSIA:&
SMAL:& SLAU:&
SALF:&(asnB)
(asnB) (asnB)SALJ:&
(asnB) (asnB) (asnB)
(asnB) KSK:&
KAB:& KAU:&
LXX:&(asn)LXY:&MIM:&CUB:&FRP:&CART:&CPHY:&AMIN:&ARM:&ARI:& ARE:&AAQ:&ARW:& APN:&RSA:& KFV:&RAJ:&SATK:&BFA:& BRX:&BGG:&(asnB)BRZ:& (asnB)DVA:&LMOI:&XCE:&SKE:&CGA:&ICA:&DCO:&(asnB)PFR:&(asnB)PFRE:&PBO:& AACI:& MPH:&(asnB)TEZ:&NDK:&(asnB)TFU:&NDA:& NAL:&SRO:&
FRE:&FRI:&
(asnO)FSY:&NML:&
GOB:& BSD:& (asnB) MMAR:& (asnB)KRA:&SEN:&(asn1) (asnB-1)SVI:& AMD:&(asnB) (asnB) (asnB) (asnB)AMN:&
AMM:&(asnB) (asnB) (asnB) (asnB)AMZ:&(asnB) (asnB) (asnB) (asnB)AOI:&(asnB) (asnB) (asnB) (asnB)AJA:&(asnO1) (asnB1) (asnO2) (asnB2)AMQ:&
(asnB) (asnB) (asnB) ALU:&
PSEA:& PSEE:&
APRE:&(asnB) (asnB) SESP:&(asnB)
AHM:& ACTI:&
AHG:& (asnO1) (asnO2) (asnB)ALL:&
AMS:& ASE:&
(asn1) (asnH) (asnB)ACTN:&(asnB)
AFS:& PLK:& (asnB) (asnB)CAI:&
SNA:&TPY:&TPYO:&ACQ:&AOS:& AVU:&ACTP:&BLN:&BLON:&BAD:&(asnH)BADL:&BADO:&BDE:&(purF)BDN:&BBRN:&BCOR:&BII:&BANG:&BACT:&GVA:&(asnB)PDO:&TBI:&AEY:&(asnB) (asnB) (asnB) (asnB) (asnB)NHI:&RRD:&CWO:& CCU:&ELE:&
EYY:&(AsnB)GPA:& AEQ:&DDT:&CGO:&CAER:&(asnB)CBAC:& SYW:&(asnB)SYD:&SYE:&SYG:&(asnB)SYR:& (asnB)SYNE:& SYNK:&SYNR:&SYND:&SYH:&(asnB)SYNW:&(asnB)TEL:&THN:&CGC:& CYI:&(asnB)CMP:& LEN:& LET:&(asnB_1) (asnB_2)LBO:&
HHG:&(asnB)PMA:&(asnB)PMI:&PMH:& (asnB) PME:&(asnB)PRC:&PRM:& AMR:&(asnB) (asnB)MPK:& HAO:& CWA:&
GLP:&GEN:&GEE:&CHON:&(asnB_1) (asnB_2)CYT:&(asnB)CYC:&CYN:&
CYJ:& TER:& MIC:&
ARP:&GEI:&
OAC:&ONI:&MPRO:&
CEP:& GLJ:&(asnB)NPU:&
NOP:&NFL:& ANB:& (asnB)ACY:& AWA:&CSG:&
CALO:&CALT:&
CTHE:&SCS:& RRS:&
CAG:& HAU:&
ATM:&(asnB) ABAT:&CAP:&DDR:&(asnB)DMR:&DSW:& TTH:&MRB:& MRE:& CCZ:&TTR:&
PUV:& (asnB)WCH:&(asnB1) (asnB3)OTE:&
OBG:&(asnB)VBA:&RBA:& (asnB) (asnB)PSL:&PIR:&(asnB_1)
(asnB_2)PLM:& PBS:&
PLS:&(asnB_1)
(asnB_2) (asnB_3)PLH:&(asnB_1) (asnB_2) (asnB_3)
(asnB_4) (asnB_5)FMR:&(asnB_1) (asnB_2) (asnB_3) TTF:&GES:&(asnB) IPA:&
PBOR:&(asnO)
(asnB_1) (asnB_2) (asnB_3) (asnB_4) (asnB_5)PHM:&VBL:&(asnB_1) (asnB_2) (asnB_3)TSU:&TBE:&TPI:&(asnB)SSM:&SBU:&SCC:&SGP:&TPX:& ACA:&(asnB1) (asnB2) ACM:&GMA:&TSA:&TRS:& SUS:&
CTM:&ABAC:& (asnB_1) (asnB_2) (asnO)IPO:&STR:&CPOR:&GAU:&(asnB)GPH:& GBA:&
BTH:&(asnB)BTHO:&(asnB)BFR:&BFS:&(asnB)BFG:&(asnB)BFB:&(asnB)BVU:&BHL:&BSA:&BXY:&BDO:&(asnB)BDH:&(asnB)BOA:&(asnB)BCEL:&(asnB)BCAC:&(asnB)BCAE:&(asnB)PGI:&PGN:&PGT:&PBT:&PMUC:&(asnB)PET:&PPN:&PDI:&PARC:&(asnB)TFO:&(asnB)BVS:&(asnB) PSAC:&(asnB)OSP:&APS:&PRU:&(asnB)AFD:&DORI:&(asnB)BLQ:&(asnB_1) (asnB_2)ASX:& SRM:&(asnB)
(asnB)RMR:&
NKO:&FLA:& (asnB) FLN:&HHY:&
SGN:&(asnB) (asnB)PEP:&
PGS:&(asnB)PSN:& SHG:&SHT:&(asnB)SPHN:&(asnB)MUP:&MUC:& CMR:&CAMU:&
BBD:&EVI:&ALM:&
CHU:&(asnB) (asnB) (asnB)DFE:&SLI:&SRD:&SMON:&SPIR:&LBY:&RSI:& EOL:&FAE:&(asnB)FIB:& FLI:& HSW:&HYM:&HYD:&HYE:&HYG:&HYP:&HYZ:&PKO:&(asnB)RUF:&
(asnB)RTI:&(asnB) RUD:&MTT:& FLM:&FBT:&
(asnB)AAS:&GFO:&(asnB) (asnB) GRL:&
GFL:& FJO:& FJG:&(asnB_1) (asnB_2)FPS:& (asnB)FPC:& FPY:& FPO:& FPQ:& FPV:& FPW:& FPK:& FPSZ:&FBR:& (asnB2) (asnB1)FCO:&(asnB)FIN:& (asnB) FCM:&RBI:&ZPR:& CAT:& RAN:& RAI:& RAR:&
RAG:&RAE:&
RAT:& FBC:&MARM:&(asnB)MART:&(asnB)MARB:&(asnB)CAO:&CLY:& CLH:&(asnB)CBAL:&(asnB)CBAT:&(asnB)KDI:&DOK:&(asnB)DDO:&(asnB)LAN:&LVN:&(asnB)LACI:&(asnB)ZGA:& (asnB1) (asnB2) (asnB3)MRS:&MLT:&ASL:&
ORH:&ORI:&(asnB)PTQ:&NDO:&(asnB)NOM:&(asnB)NSD:&(asnB)NOB:&(asnB)POM:&POB:&EAO:&EMN:&(asnB)EEN:&(asnB)ELB:&(asnB_1) (asnB_2)EMG:&(asnB)EGO:&(asnB)EGM:&(asnB)MYR:&(asnB)MPW:&MOD:&CHZ:& CGN:& (asnB)CIH:&(asnB)
CHH:&(asnB)
CIO:&(asnB)
(asnB) (asnB)CHRY:&(asnB) (asnB)CPIP:&(asnB)WIN:& WIJ:& (asnB)SYI:&(asnB)TDI:&(asnB)TJE:&(asnB)TMAR:&(asnB)LUT:&(asnB) LUL:&FOR:&FOH:&SALT:& (asnB) SEON:&AALG:&(asnB)OLL:&(asnB)FBA:&FBU:&(asnB|ASNS)FTE:& FLU:&(asnB)OHO:& BBAU:&
CPC:&PVI:&PLT:&PAA:&PROC:&(asnB)PROS:&(asnB)CTS:&
IAL:&(asnB) (asnB)CACI:& (asnB) HYA:&HHO:&HYS:&TRD:&SAF:&(asnB)TRQ:&PHY:& TME:&FIA:&MPZ:& MARN:&
KOL:&MPG:& CABY:&
TYE:&(asnB)NDE:&(asnB) (asnB)
(asnB4)NMV:&
(asnB) NIO:&
TID:& TOP:&CTHI:&
MIB:&WBA:&MJA:& MFE:&MVU:&MFS:&MIF:& MJH:&MIG:& MMP:&(asnB)MMQ:& MMX:&MMZ:&MMD:&MMAK:&(asnB)MMAO:&(asnB)MAE:&MVN:&MVO:&MOK:& MAC:& (asn)MBA:&MBY:& MBW:&MBAR:& MBAK:& MMA:& MMAZ:&MMJ:& MMAC:& MVC:&MEK:&MLS:& METM:&MEF:&MEQ:&MSJ:&MSZ:&MSW:&MTHE:&MTHR:&MHOR:&
MBU:& MMET:& MEV:&MPY:& MCJ:&(asnB)MHI:&MHU:&MLA:&MEM:& MBG:&(asnB1)
(asnB3)MEMA:&(asnB)
(asnB)MPI:& MBN:& MFO:& MPL:& MPD:&MEZ:&(asnB-1) (asnB-2)RCI:&(asnB-1) (asnB-2)MTH:&MMG:&(asnB)METC:&MWO:&MST:&MSI:&MRU:&(asnB)MEB:&(asnB)MMIL:&(asnB)MEYE:&MOL:&MEL:& MEW:& METH:&MFC:&(asnB)MFI:&
MCUB:&MFV:&MKA:&(asnB)AFU:&AFG:&APO:&AVE:& AST:&FPL:&GAC:&GAH:&HAL:&(asnA)HSL:&(asnB)HDL:&HHB:&(asnB)HJE:&
HMA:&(asnB)HHI:&(asnB) HHN:& HAB:& NPH:&(asnB)NMO:&(asnB)HUT:&HTI:&HMU:&HALI:&
HAE:&HWA:&(asnB)HWC:&(asnB1) (asnB2)HVO:&(asnB) HME:&(asnB) HGI:& HBO:&HLA:&HTU:&
NAT:& NPE:&NGE:&
HRU:&NOU:&
SALI:& HLR:& HLC:&
NAJ:& TAC:&TVO:&(TVG0427721)PTO:&FAC:&FAI:&CDIV:&TAR:& MAX:& MER:& MEAR:& MARC:& PHO:&(PH1102)PAB:&(asnB) PFU:& PFI:& PYN:&PYA:&PYS:&PYC:&TKO:&TON:&TGA:& (asnB) TSI:& TBA:&THE:&THA:&THM:&TLT:&THS:&TNU:&TEU:&TGY:&THV:&TCH:&TPEP:&TPIE:&TGG:&TCE:&TBS:&THH:&TSL:&TTD:&TPRF:&TRL:&TPAF:&PPAC:&ABI:&ACF:&APE:&IHO:&IAG:&PFM:&PAI:&PIS:&PCL:&PYR:&POG:&TNE:&PYW:&TUZ:&TTN:&(asnB)ASC:&CLG:&FFO:& NMR:& NIR:& NID:& NIN:& NKR:& NCT:&
NGA:&(asnB1)
(asnB2) NVN:&(asnB) (asn1) (asn2) NEV:&
TAA:&(asnB_1) (asnB_2) (asnB_3) (asnB_4)CSU:&NBV:&
NDV:& BARC:&BARB:& LOKI:&(asnB)HAH:&AGW:& (asnB)
1&&[PMID:]
Patterson MK Jr, Orr GR.
Asparagine biosynthesis by the Novikoff Hepatoma isolation, purification, property, and mechanism studies of the enzyme system.
J. Biol. Chem. 243 (.
2&&[PMID:]
Boehlein SK, Richards NG, Schuster SM.
Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad.
J. Biol. Chem. 269 (-7.
&&Sequence
3&&[PMID:]
Richards NG, Schuster SM.
Mechanistic issues in asparagine synthetase catalysis.
Adv. Enzymol. Relat. Areas. Mol. Biol. 72 (.
4&&[PMID:]
Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I.
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.
Biochemistry. 38 (-57.
&&Sequence
5&&[PMID:]
Huang X, Holden HM, Raushel FM.
Channeling of substrates and intermediates in enzyme-catalyzed reactions.
Annu. Rev. Biochem. 70 (.
6&&[PMID:]
Tesson AR, Soper TS, Ciustea M, Richards NG.
Revisiting the steady state kinetic mechanism of glutamine-dependent asparagine synthetase from Escherichia coli.
Arch. Biochem. Biophys. 413 (.
&&Sequence
ExplorEnz - The Enzyme Database:&IUBMB Enzyme Nomenclature:&ExPASy - ENZYME nomenclature database:&BRENDA, the Enzyme Database:&CAS:&
&&All links&&
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