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Luis Alberto Diaz, Jr, M.D.
Associate Professor of Oncology
Languages: English, Spanish
Expertise: Colorectal Cancer, Medical Oncology, Pancreatic Cancer
Research Interests:
Gastrointestinal cancers
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231
Phone: 410-955-8964
Background
Dr. Luis Diaz is an associate professor of oncology at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center. He has pioneered several genomic diagnostic and therapeutic approaches for cancer. He is an attending physician at the Johns Hopkins Hospital where he specializes in the treatment of pancreatic and colorectal cancers. He is currently a member of the Ludwig Center for Cancer Genetics and Therapeutics where he directs translational medicine and is the Director of the Swim Across America Laboratory. Dr. Diaz has undergraduate and medical degrees from the University of Michigan, and completed residency training at the Osler Medical Service at Johns Hopkins and medical oncology training at the Johns Hopkins Kimmel Cancer Center.Dr. Diaz is involved in translational research studies with the goal of bringing diagnostic and therapeutic genomic strategies to patients with cancer. His work has involved the clinical development of tumor-derived DNA as a biomarker for cancer screening, early detection, monitoring and measurement of early residual disease. The work is based on the well-accepted premise that cancer is defined by a discrete set of genetic alterations. This approach combines next-generation genomic sequencing with novel digital techniques to count tumor-derived DNA fragments in complex mixtures of DNA. He has demonstrated that the level of mutations circulating in blood, also known as circulating tumor DNA (ctDNA), tracked with fluctuations in tumor burden in patients undergoing curative surgery for colorectal cancer.&Most striking is the ability of ctDNA to accurately predict recurrence after surgery and monitor patients with undetectable CEA levels. This novel biomarker is based on personalized genomics that in essence provides a viral load equivalent for patients with solid tumors. The preliminary studies served as the basis for his invention, the molecular pap smear, which is a promising approach for the early detection of ovarian and endometrial cancers. This work was highlighted in the New York Times, NPR, CNN and NBC Nightly News.
Associate Professor of Oncology
Departments / Divisions
Centers & Institutes
MD, University of Michigan Medical School (1998)
Residencies
Johns Hopkins University School of Medicine / Internal Medicine (2001)
Fellowships
Johns Hopkins University School of Medicine / Oncology (2003)
Johns Hopkins University School of Medicine / Oncology (2004)
Lab Website:
Clinical Trial Keywords colon cancer, pancreas cancer, GI cancers, molecular diagnostics, experimental therapeutics
Selected Publications
PublicationsLeary, Rebecca J, Mark Sausen, Isaac Kinde, Nickolas Papadopoulos, John D. Carpten, David Craig, Joyce OShaughnessy, Kenneth W. Kinzler, Giovanni Parmigiani, Bert Vogelstein, Luis A. Diaz and Victor E. Velculescu. Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing. Sci Transl Med 28 November 2012: Vol. 4, Issue 162, p. 162ra154. PMID: .Sausen M, Leary RJ, Jones S, Wu J, Reynolds CP, Liu X, Blackford A, Parmigiani G, Diaz LA Jr, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE, Hogarty MD. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet. 2012 Dec 2. PMID: Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih IeM, Kurman R, Dao F, Levine DA, Giuntoli R, Roden R, Eshleman JR, Carvalho JP, Marie SK, Papadopoulos N, Kinzler KW, Vogelstein B, Diaz LA Jr. Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers. Sci Transl. Med. 5(167):167ra4 2013 Jan 9 PMID: .Diaz, LA Jr, Richard T. Williams, Jian Wu, Isaac Kinde, J. Randolph Hecht, Jordan Berlin, Benjamin Allen, Ivana Bozic, Johannes G. Reiter, Martin A. Nowak, Kenneth W. Kinzler, Kelly S. Oliner & Bert Vogelstein. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature. 486, 537540.Velculescu VE, Diaz LA Jr. Understanding the enemy. Sci Transl Med. 2011 Aug 31;3(98):98ps37. PMID: .Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA Jr, Allen PJ, Schmidt CM, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development. Sci Transl Med. 2011 Jul 20;3(92):92ra66. PMID: .Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA Jr, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N. DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors. Science 2011 Jan 20. PMID: .Jones S, Wang TL, Shih IM, Mao TL, Nakayama K, Roden R, Glas R, Slamon D, Diaz LA Jr, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma. Science. 2010 Sep 8. PMID: .He Y, Wu J, Dressman DC, Iacobuzio-Donahue C, Markowitz SD, Velculescu VE, Diaz LA Jr, Kinzler KW, Vogelstein B, Papadopoulos N. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature. 2010 Mar 25;464(. PMID: .Rebecca J. Leary, Isaac Kinde, Frank Diehl, Kerstin Schmidt, Chris Clouser, Cisilya Duncan, Alena Antipova, Clarence Lee, Kevin McKernan, Francisco M. De La Vega, Kenneth W. Kinzler, Bert Vogelstein, Luis A. Diaz Jr., Victor E. Velculescu. Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing. Sci Transl Med. 2010 Feb 24;2(20):20ra14. PMID: .Holdhoff M, Schmidt K, Donehower R, Diaz LA Jr. Analysis of Circulating Tumor DNA to Confirm Somatic KRAS Mutations. J Natl Cancer Inst. 2009 Jul 29. PMID: .Meng Li, Wei-dong Chen, Nickolas Papadopoulos, Steven Goodman,Niels Christian Bjerregaard, Sren Laurberg, Bernard Levin, Hartmut Juhl, Nadir Arber, Helen Moinova, Kris Durkee, Kerstin Schmidt, Yiping He, Frank Diehl, Victor E Velculescu, Shibin Zhou1, Luis A Diaz, Jr, Kenneth W Kinzler, Sanford D Markowitz, Bert Vogelstein. Digital quantification of DNA methylation in plasma and stool samples. Nat Biotechnol. 2009 Aug 16. PMID: .Jihye Yun, Carlo Rago, Ian Cheong, Ray Pagliarini, Philipp Angenendt, Harith Rajagopalan, Kerstin Schmidt, James K. V. Wilson, Sandy Markowitz, Shibin Zhou, Luis A. Diaz, Jr, Victor Velculescu, Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells. Science. 2009 Aug 6. PMID: .Parsons DW, Jones S, Zhang X, Lin JC-H, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu I-M, Gallia G, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, Kazue SNM, Shinjo SMO, Yan H, Riggins GR, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. An Integrated Genomic Analysis of Human Glioblastoma Multiforme. Science 7-12. PMCID: PMC2820389.Diehl F, Schmidt K, Choti M, Goodman S, Li M, Romans K, Thornton K, Agrawal N, Szabo SA, Kinzler KW, Vogelstein B, Diaz LA Jr. Circulating Mutant DNA to Assess Tumor Dynamics. Nature Medicine -90. PMCID: PMC2820391.Rago C, Huso DL, Diehl F, Karim B, Liu G, Samuels Y, Velculescu VE, Vogelstein B, Kinzler KW, Diaz LA Jr. Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA. Cancer Res. 4-70.Peters BA., Luis A. Diaz, Kornelia Polyak, Kathy Romans, Eva C. Guinan, Joseph H. Antin, Michael Collector, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer. Contribution of bone-marrow derived stem cells to human tumor vasculature. Nat Med. -262.Samuels Y, Luis Diaz, Jr., Jordan Cummins, Laura DeLong, Ian Cheong, David L. Huso, Kenneth W. Kinzler, Christoph Lengauer, Bert Vogelstein, Victor E. Velculescu. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell -573.Ian Cheong, Xin Huang, Chetan Bettegowda, Luis A. Diaz, Jr., Kenneth W. Kinzler, Shibin Zhou, Bert Vogelstein. A C. novyi-NT Protein Enhances the Release and Efficacy of Liposomal Cancer Drugs. Science 08-1311.
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> 游戏英文网名大全lol
游戏英文网名大全lol
随着社会的进步发展，人们的工作压力也越来越大，人们解压的方法各种各样，有人去健身、有人去打游戏。说起打游戏小编想起了周杰伦，他也是一位游戏狂热迷，不久前的LOL五周年庆典对抗赛，杰伦和韩星金希澈激情开战。说到这里你是不是也很想玩呢？但是玩游戏前必须给角色起一个，不知道怎么起的朋友们，不妨看下小编带来的lol游戏英文网名。
lol游戏英文网名技巧
1、拓展角色名字
游戏中有许多的角色，有的角色它自己的名字本来就非常的好听，甚至有的角色被玩家起了昵称，我们可以用他们自己的名字、昵称拓展一下，然后化为我们自己的名，几个例子如lol里面的扭曲树精茂凯，我们可以拓展为酷炫炸天的茂凯。如：最强胸器拉克丝、德玛西亚的嘉文、霸气侧漏之普朗克船长。
2、添加火星文符号
我们玩游戏的时候，最常见的就是一串文字，虽然名字听着感觉很厉害，但是就这么看会显得过于单调，显示不出自己的特色。所以我们可以添加一些火星文符号，这样名字就会出众许多。如：One、Life 独厮守 ぢ、A monologue. 独白、豹纹 swxy&、kingb心跳 n等。
游戏英文lol
3、动漫人物取名
我们在小的时候肯定看过动漫，小时候电视播放的动漫远比现在的好看，动漫里面不缺乏强大的角色，例如8090后的经典动漫之一的《火影忍者》，里面有许多超级厉害的人，我们可以用他们的名字给自己取网名，例如大蛇丸sam丶、爱吃拉面の鸣人、宇智波^_^我爱鼬等。
lol游戏英文名
亻Man, I love
One、Life 独厮守 ぢ.
A monologue. 独白。
/冷淡丨desolate。
neuropathy
love dance
lonely barr
Night's Aspect
Rosemary颖
Sunflower颖
King of dance-hyun
Like dying
Pr&иCess┾&
Dancer 咏恒
tears-foxmai
b ` sentence
Fleeting r
Spread love
Love, injury っ
Are near r
Ruthless happiness
Killer Blade
lol游戏英文网名大全
臭臭　cheeks
aPretended
逃荒　Apersong
潮轨迹 Tokyo
局外人 (Fa1r)
Ace Killek
Machine gun
lowers情调。
$up3rman 不二情
Cemetery&囚碟
玩命dancers
万念 mannen
Guards寂寞
Μystery
Saint Soldier
Supporting role
Memory Collection
Gloaming 薄暮城
Charm 猫姬
Left farewell.
Like multitudinous
Domineering
Emperor 帝王
Lucifer mike
Daemonic &魔鬼
Angel_baby
Muhammadan
Arrogance 傲气
Blood oath 誓血
GOD &Alory
Lina Inverse
John William
&empress　征服你
Sadness 无心的人
Tout-An.诺粞
冷温柔&Triste
拾字露口&felicity
豹纹 swxy&
kingb心跳 n 、
Invisible Love
a暗里着迷　Dreamland
挂念 - hcs/u3
retrospection（追忆）
浅时光　BonnenuIt
生死相随 lose heart
毒光　Strong
醉凡尘￠ Wor
小矜持。reserved
流年碎　jonathan
凉岛 /MATAHARI
欧典-the empty
灵魂属于kenneth &
食人摩 diable&
温揉 tender%
Hide however
花黎．punma
亡命.honoria
取网名是一件有意思的事情，但是千万别触及法律的名字哦。以上就是的全部内容，希望能帮助您取一个好听的名字。
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