Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:Microtubule-actin cross-linking factor 1Macf1Rattus norvegicus (Rat)-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveliFunctioniF-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).RegionsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsCalcium bindingi121Calcium bindingi122GO - Molecular functioniGO - Biological processiKeywords - Biological processiKeywords - Ligandi, , Names & TaxonomyiProtein namesiRecommended name:Microtubule-actin cross-linking factor 1Alternative name(s):Actin cross-linking family 7Gene namesiName:Macf1Synonyms:Acf7, Aclp7, MacfOrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi Componenti: Unplaced Organism-specific databases
RGDi Macf1. Subcellular locationi &
"The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.", , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AXIN1 AND LRP6, IDENTIFICATION IN A COMPLEX WITH AXIN1; APC; GSK3B AND CTNNB1.
Note: Localizes to the tips of microtubules. APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization. The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity).GO - Cellular componentiKeywords - Cellular componenti, , , , , PTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsChaini5430Microtubule-actin cross-linking factor 1PRO_Amino acid modificationsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsModified residuei1Phosphoserine"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1Phosphoserine"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1Phosphoserine"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1Phosphoserine"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1Phosphoserine"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphothreonineModified residuei1Phosphoserine"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1N6-acetyllysineModified residuei1PhosphoserineModified residuei1Phosphothreonine"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5296, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Modified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserineModified residuei1PhosphoserinePost-translational modificationiPhosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation (By similarity).Keywords - PTMi, Proteomic databases
PeptideAtlasi PTM databases
iPTMneti InteractioniSubunit structureiInteracts with MAPRE1, CLASP1, CLASP2 and GOLGA4 (By similarity). Interacts with AXIN1 and LRP6. Found in a complex composed of MACF1, APC; AXIN1, CTNNB1 and GSK3B."The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.", , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AXIN1 AND LRP6, IDENTIFICATION IN A COMPLEX WITH AXIN1; APC; GSK3B AND CTNNB1. Protein-protein interaction databases
STRINGi Structurei3D structure databases
ProteinModelPortali
MobiDBiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsDomaini295Actin-bindingDomaini104CH 1Repeati24LRR 1Domaini102CH 2Repeati25LRR 2Repeati23LRR 3Repeati24LRR 4Domaini53SH3Repeati24LRR 5Repeati27LRR 6Repeati24LRR 7Repeati26LRR 8Repeati24LRR 9Repeati25LRR 10Repeati76Spectrin 1Repeati23LRR 11Repeati109Spectrin 2Repeati26LRR 12Repeati27LRR 13Repeati109Spectrin 3Repeati24LRR 14Repeati24LRR 15Repeati24LRR 16Repeati105Spectrin 4Repeati104Spectrin 5Repeati26LRR 17Repeati23LRR 18Repeati106Spectrin 6Repeati24LRR 19Repeati103Spectrin 7Repeati104Spectrin 8Repeati105Spectrin 9Repeati25LRR 20Repeati103Spectrin 10Repeati25LRR 21Repeati106Spectrin 11Repeati105Spectrin 12Repeati104Spectrin 13Repeati107Spectrin 14Repeati104Spectrin 15Repeati24LRR 22Repeati107Spectrin 16Repeati102Spectrin 17Repeati105Spectrin 18Domaini36EF-hand 1Domaini36EF-hand 2Domaini73GARRegionFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsRegioni272C-terminal tailRegioni164 X 4 AA tandem repeats of [GS]-S-R-[AR]Compositional biasFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsCompositional biasi4Poly-GluCompositional biasi4Poly-GluCompositional biasi138Ser-richDomainiThe C-terminal tail is required for phosphorylation by GSK3B and for microtubule-binding.Sequence similaritiesiContains 1 .Contains 2 s.Contains 2 s.Contains 1 .Contains 22 s.Contains 1 .Contains 18 s.Keywords - Domaini, , Phylogenomic databases
eggNOGi Eukaryota.
InParanoidi Family and domain databases
Gene3Di 1 hit.
InterProi Actinin_actin-bd_CS.
CH-domain.
EF-hand-dom_pair.
EF_Hand_1_Ca_BS.
EF_hand_dom.
Spectrin/alpha-actinin.
Spectrin_repeat.
PANTHERi PTHR11915:SF37. 5 hits.
Pfami CH. 2 hits.
EF-hand_7. 1 hit.
GAS2. 1 hit.
Spectrin. 18 hits.
SMARTi CH. 2 hits.
EFh. 2 hits.
GAS2. 1 hit.
SPEC. 34 hits.
SUPFAMi SSF hit.
SSF47473. 1 hit.
SSF47576. 1 hit.
PROSITEi ACTININ_1. 1 hit.
ACTININ_2. 1 hit.
CH. 2 hits.
EF_HAND_1. 2 hits.
EF_HAND_2. 2 hits.
GAR. 1 hit.
[]SequenceiSequence statusi: Complete.D3ZHV2-1 []
50MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH
100EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN
150DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ
200VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL
250LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQIQS
300NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV
350PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI RQHTILMSDK SFPQNPVELK
400ALYNQYIHFK ETEILAKERE KGRIKELYKL LEVWIEFGRI KLPQGYHPNH
450VEEEWGKLIV EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA
500KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDEKYY
550QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP STLTTTHLKA
600EPLNKTTHSS STSWFRKPMT RTELVAISSS EDEGSLRFVY ELLSWVEEMQ
650MKLERAEWGN DLPSVELQWE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF
700HTSYVETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSKAT AELIWLNGKE
750EEELACDWSD SNPNISAKKA YFSELTMELE GKQDVFRSLQ DTAELLSLEN
800HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HIKENAAYFQ FFSDARDLES
850FLRNLQDSIK RKYTCDHNTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG
900RSKTIVQLKP RNPDHVLKST LSVKAICDYR QIEITICKND ECVLEDNSQR
950TKWKVISPTG NEAMVPSVCL LIPPPNTEAI DVASRVEQSY QKVMALWHQL
1000HINTKSLISW NYLRKDIDAV QTWNLEKLRS SAPGECHQVM KNLQAHYEDF
1050LQDSHDSALF SVADRLRIEE EVEACKTHFQ QLMESMENED KEETLAKVYI
1100SELKNIRLRL EECEQRLLKQ IQSSASSKTD RDARQDVALR IAEQEHVQED
1150LKHLRSDLDA VSVKCTTFLQ QSPSGSSATT LRSELNLMVE KMDHVYGLSI
1200VCLNKLKTID VIVRSIQDAE LLVKGYEIKL SQEEAVPADL SALESHRTTL
1250QHWLSDVKDK NSVFSVLDEE ISKAKAVAEQ LHHRAAEPNL DLERYQEKGS
1300QLQERWHRVI AQLETRQSEV ESIQEVLRDY RACHGTLIKW IEETTAQQEM
1350MKPGQAEDSR VLSEQLSQQT ELFAEIERNQ TKLDQCQKLS QQYSTTVKDY
1400ELQLMTYKAF VESQQKSPGK RRRMISSSDA ITQEFMDLRT RYTALVTLTT
1450QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKDLLGWVST LARNTQGTTT
1500SSRTSASTDI EKAILEQQVL AEELTTKKEQ VSEAIKTSQI FLAKHGHKLS
1550EREKEQISEQ LCALNKTYHD LCDGSANQLQ QLQSELAQQT EQKTLQKQQD
1600TCHKKLEDLR SWVRQAERAL ERHRGRASQQ ELSALQQNQS DLKDLQGDIQ
1650NHSTSFATAV KDIEGFLEEN QNKLSPQELT ALREKLYQAK EQYEGLQDRT
1700REAQKELEEA VTSALQQETE KSKAATELAE NRRKIDALLD WVTSVGSSDR
1750QPQTSLPGTE QFSGACLEKQ TLDATDGCVD VNQVPEKLDR QYELMKARHQ
1800ELLSQQQNFI VATQSAQSFL DQHSHNLTPE ERQMLQEKLG ELKEQYAASL
1850AQSEAKLRQT QTLRDELQKF LQDHREFENW LERSENELDG MHTGGSSPEA
1900LNSLLKRQGS FSEDVISHKG DLRFVTISGQ KVLETENNFE EGQEPSPTRN
1950LVNEKLKDAT ERYTTLHSKC TRLGSHLNML LGQYQQFQSS ADSLQAWMLT
2000CEASVEKLLS DTVASDPGIL QQQLATTKQL QEELAEHQVP VEKLQKAAHD
2050LMDIEGEPSL DCTPIRETTE SIFSRFQSLS CSLAERSALL QKAIAQSQSV
2100QESMESLLQS MKEVEQNLEG EQVAALSSGL IQEALANNMK LKQDIARQKS
2150SLEATREMVT RFMETADGNS AAVLQDRLAE LSQRFHRLQL QQQEKESGLK
2200KLLPQAETFE QLSSKLQQFV EHKNRLLASG NQPDQDIAHF SQHIQELTLE
2250MEDQKENLGT LEHLVTALGS CGFALDLSQH QEKIQNLKKD FTELQKTVQE
2300REKDASNCQE QLDEFRKLIR TFQKWLKETE GNVPPAETFV SAKELEKQIE
2350HLKGLLDDWA GKGVLVEEIN TKGTALESLI MDITAPDSQA KTGSVLPSVG
2400SSVGSVNGYH TCKDLTEIQC DMSDVNSKYD KLGDALRERQ ESLQTVLSRM
2450EEVQKEASSV LQWLESKEEV LKGMDASLSP TKTETVKAQA ESNKAFLAEL
2500EQNSPKIQKV KEALAGLLEA YPNSQEAENW RKMQEDLNSR WEKATEVTVA
2550RQKQLEESAS HLACFQAAES QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK
2600QQVQFMLKEF EARRQQHEQL TEAAQGILTG PGDVSPSASQ VHKDLQSISQ
2650KWVELTDKLN SRSTQIDQAI VKSTQYQDLL QDLSEKVKAV GQRLSGQSAI
2700STQPDAVKQQ LEETSEIRSD LGQLDDEMKE AQTLCQELSL LIGEQYLKDE
2750LKKRLETVAL PLQGLEDLAA DRMNRLQAAL ASTQQFQQMF DELRTWLDEK
2800QSQQAKNCPI SAKLERLQSQ LQENEEFQKN LNQHSGSYEV IVAEGESLLL
2850SVPPGEEKKT LQNQLVELKS HWEDLNKKTV DRQSRLKDCM QKAQKYQWHV
2900EDLVPWIKDC KSKMSELQVT LDPVQLESSL LRSKAMLNEA EKRRSLLEIL
2950NSAADILINS SEIDEDEIRD EKAGLNQNMD AITEELQAKT GSLEEMTQRL
3000KEFQESFKNI EKKVEGAKHQ LEIFDALGSQ ACSNKNLEKL KAQREVLQAL
3050DPQVDYLRDF TRGLVEDAPD GSDASPLVHQ AELAQQEFLE VKQRVNSSCL
3100TMENKLEGIG QFHCRVREMF SQLADLDDEL DGMGAIGRDT DSLQSQIEDI
3150RLFLNKIQAL RLDIEDSEAE CRKMLEEEGT LDLLGLKREL EALNKQCGKL
3200TERGKARQEQ LELTLGRVED FYSKLKALND AATAAEEGEA LQWIVGTEVD
3250VINQQLADFK MFQKEQVDPL QVKLQQVNGL GQGLIQSAGK TCDVQGLEHD
3300MEEVNTRWNT LNKKVAQRIA QLQEALLHCG KFQDALEPLL SWLTDTEELI
3350ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR KATVDMLQAE GGRIAQAAEL
3400ADREKITGQL ESLECRWTEL LSKAAARQKQ LEDILVLAKQ FHETAEPISD
3450FLSVTEKKLA NSEPVGTQTA KIHQQIIRHK ALEEEIENHA ADVQQAVKIG
3500QSLSSLICPA EQGIMSEKLD SLQARYSEIQ DRCCRKASLL EQALFNARLF
3550GEDEVEVLNW LAEVEDKLSA VFVKDYRQDV LQKQHADHLA LNEEIINRKK
3600NVDQAIKNGQ ALLKQTTGEE VLLIQEKLDG IKTRYADITV TSSKALRTLE
3650QARQLATKFH STYEELTGWL REVEEELAAS GGQSPTGEQI PQFQQRQKEL
3700KKEVMEHRLV LDTVNEVSHA LLELVPWRAR EGLDKLVSDA NEQYKLVSDT
3750VGQRVDEIDA AIQRSQQYEQ AADAELAWVA ETKRKLMALG PIRLEQDQTT
3800AQLQVQKAFS IDIIRHKDSM DELFSHRGEI FSTCGEEQKA VLQEKTECLI
3850QQYEAVSLLN SERYARLERA QVLVNQFWET YEELSPWAEE TLALIAQLPP
3900PAVDHEQLRQ QQEEMRQLRE SIAEHKPHID KILKIGPQLK ELNPEEGKMV
3950EEKYQKAENM YAQIKDEVRQ RALALDEAVS QSAQIAEFHD KIEPMLETLE
4000NLSSRLRMPP LIPAEVDKIR ECISDNKSAT MELEKLQPSF EALKRRGEEL
4050IGRSQGADKD LAAKEIQDKL DQMVFFWEDI KARSEEREIK FLDVLELAEK
4100FWYDMAALLT TIKDTQEIVH DLESPGIDPS IIKQQVEAAE TIKEETDGLH
4150EELEFIRILG ADLIFACGET EKPEVKKSID EMNNAWENLN RTWKERLEKL
4200EDAMQAAVQY QDTLQAMFDW LDNTVIRLCT MPPVGTDLNT VKDQLNEMKE
4250FKVEVYQQQI EMEKLNHQGE LMLKKATDET DRDIIREPLT ELKHLWENLG
4300EKIAHRQHKL EGALLALGQF QHALEELMGW LTHTEELLDA QRPISGDPKV
4350IEVELAKHHV LKNDVLAHQA TVETVNKAGN ELLESSAGDD ASSLRSRLET
4400MNQCWESVLQ KTEEREQQLQ STLQQAQGFH SEIEEFLLEL NRMESQLSAS
4450KPTGGLPETA REQLDAHMEL HSQLRAKEEI YNQLLDKGRL MLLSRGDSGS
4500GSKTEQSVAL LEQKWHVVSS KVEERKSKLE EALSLATEFQ NSLQEFINWL
4550TLAEQSLNIA SPPSLILNTV LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ
4600LKFLSQKQDV VLIKNLLVSV QSRWEKVVQR SIERGRSLDD ARKRAKQFHE
4650AWKKLIDWLE DAESHLDSEL EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY
4700DTTIRTGRAL KEKTLLADDA QKLDNLLGEV RDKWDTVCGK SVERQHKLEE
4750ALLFSGQFMD ALQALVDWLY KVEPQLAEDQ PVHGDLDLVM NLMDAHKVFQ
4800KELGKRTGTV QVLKRSGREL IESSRDDTTW VKGQLQELST RWDTVCKLSV
4850SKQSRLEQAL KQAEEFRDTV HMLLEWLSEA EQTLRFRGAL PDDTEALQSL
4900IDTHKEFMKK VEEKRVDVNA AVAMGEVILA VCHPDCITTI KHWITIIRAR
4950FEEVLTWAKQ HQQRLETALS ELVANAELLE ELLAWIQWAE TTLIQRDQEP
5000IPQNIDRVKA LITEHQSFME EMTRKQPDVD RVTKTYKRKN IEPTHAPFIE
5050KSRSGSRKSL NQPTPPPMPI LSQSEAKNPR INQLSARWQQ VWLLALERQR
5100KLNDALDRLE ELKEFANFDF DVWRKKYMRW MNHKKSRVMD FFRRIDKDQD
5150GKITRQEFID GILASKFPTT KLEMTAVADI FDRDGDGYID YYEFVAALHP
5200NKDAYRPTTD ADKIEDEVTR QVAQCKCAKR FQVEQIGENK YRFGDSQQLR
5250LVRILRSTVM VRVGGGWMAL DEFLVKNDPC RARGRTNIEL REKFILPEGA
5300SQGMTPFRSR GRRSKPSSRA ASPTRSSSSA SQSNHSCTSM PSSPATPASG
5350TKVISSTGSK LKRPTPTFHS SRTSLAGDTS NSSSPASTGA KTNRADPKKS
5400ASRPGSRAGS RAGSRASSRR GSDASDFDLL ETQSACSDTS ESSAAGGQGS
5430SRRGLTKPSK IPTMSKKTTT ASPRTPCPKR
5,430619,600April 20, 2010 - v1Checksum:iC15B030F89CD5FBFBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence databases
Select the link destinations:EMBLiGenBankiDDBJi Genomic DNA. No translation available. Genomic DNA. No translation available.
UniGenei Genome annotation databases
UCSCi rat. Cross-referencesiSequence databases
Select the link destinations:EMBLiGenBankiDDBJi Genomic DNA. No translation available. Genomic DNA. No translation available.
UniGenei 3D structure databases
ProteinModelPortali
MobiDBiProtein-protein interaction databases
STRINGi PTM databases
iPTMneti Proteomic databases
PeptideAtlasi Protocols and materials databases
Structural Biology KnowledgebaseGenome annotation databases
UCSCi rat. Organism-specific databases
RGDi Macf1. Phylogenomic databases
eggNOGi Eukaryota.
InParanoidi Miscellaneous databases
PROi Family and domain databases
Gene3Di 1 hit.
InterProi Actinin_actin-bd_CS.
CH-domain.
EF-hand-dom_pair.
EF_Hand_1_Ca_BS.
EF_hand_dom.
Spectrin/alpha-actinin.
Spectrin_repeat.
PANTHERi PTHR11915:SF37. 5 hits.
Pfami CH. 2 hits.
EF-hand_7. 1 hit.
GAS2. 1 hit.
Spectrin. 18 hits.
SMARTi CH. 2 hits.
EFh. 2 hits.
GAS2. 1 hit.
SPEC. 34 hits.
SUPFAMi SSF hit.
SSF47473. 1 hit.
SSF47576. 1 hit.
PROSITEi ACTININ_1. 1 hit.
ACTININ_2. 1 hit.
CH. 2 hits.
EF_HAND_1. 2 hits.
EF_HAND_2. 2 hits.
GAR. 1 hit.
ProtoNetiPublicationsi"Genome sequence of the Brown Norway rat yields insights into mammalian evolution.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: . "The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.", , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AXIN1 AND LRP6, IDENTIFICATION IN A COMPLEX WITH AXIN1; APC; GSK3B AND CTNNB1. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5296, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", , , , , ,
[] [] []Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-280; SER-1860; SER-2429; SER-2454 AND SER-4074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. MiscellaneousiKeywords - Technical termi, Documents
Index of protein domains and families
Similar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.Glucosamine Sulfate
sulfate is a natural sugar found in and around the fluid and tissues that cushion your joints. This tissue is called cartilage.
Glucosamine is also found in the hard covering of shellfish.
Recommended Related to Vitamins & Supplements
Deer velvet is a traditional Chinese medicine treatment. Other names for it include velvet antler and antler velvet. It is made from immature deer antlers, which are covered in velvet-like hair. At this stage, the antlers are made of cartilage. The antlers also contain protein, fat, minerals, and other chemical compounds.
Glucosamine sulfate
are often made using shellfish. The substance can also be made in a laboratory.
Why do people take glucosamine sulfate?
Glucosamine sulfate is a widely used supplement that may help ease pain in people with
happens when cartilage breaks down. This can cause . Millions of people in the U.S. have .
Scientists have been studying glucosamine sulfate alone, and together with another supplement called chondroitin, for many years. Research results have been conflicting.
Some studies show the supplement reduces
in people with moderate-to-severe osteoarthritis. However, it doesn't seem to work as well in people who:
Have had the condition for a long time
The supplement seems to reduce pain as much as . But it doesn't work as fast. It can take four to eight weeks for glucosamine sulfate to ease pain.
Some studies show that glucosamine sulfate may also work for:
() in the jaw
A study in men also suggests that glucosamine sulfate may help a person bend and flex the
better after a sudden .
Optimal doses of glucosamine sulfate have not been established. Supplement ingredients and quality may vary widely from maker to maker. This makes it hard to establish a standard dose.
The dose used in many studies to treat knee osteoarthritis was 500 milligrams, taken three times a day.
There are different forms of glucosamine. Check the supplement's ingredients. Some may contain glucosamine sulfate. Other
may have glucosamine hydrochloride or another type. Most studies have used glucosamine sulfate.
Glucosamine is sometimes found in
creams used to treat
pain. There is no proof that glucosamine can move through your skin. Scientists think the pain relief may be due to other ingredients in the cream.
Studies done in a laboratory dish hint that glucosamine sulfate may help fight , the virus that causes AIDS. Much more comprehensive research is needed before scientists can say whether or not this supplement could be helpful for those with the virus.
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