RTKN rhotekin [Homo sapiens (human)] - Gene - NCBI
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RTKNprovided by
rhotekinprovided by
Primary source
See related
protein coding
RefSeq status
E M C C V E M E E P H C H Homo
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
See RTKN in
Annotation release
GRCh38.p7 ()
NC_ (441933, complement)
previous assembly
GRCh37.p13 ()
NC_ (669060, complement)
Chromosome 2 - NC_
Genomic Sequence:
NC_ Chromosome 2 Reference GRCh38.p7 Primary Assembly
NC_ Chromosome 2 Alternate CHM1_1.1
NC_ Chromosome 2 Reference GRCh37.p13 Primary Assembly
Go to nucleotide:
Related articles in PubMed
GeneRIFs: Gene References Into Functions
Title: Effect of RTKN on progression and metastasis of colon cancer in vitro.
Title: Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells.
Title: Protein kinase D regulates RhoA activity via rhotekin phosphorylation.
Title: miR-145 inhibits breast cancer cell growth through RTKN.
Title: Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin.
Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Title: Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis.
Title: Association between clinical characteristics and expression abundance of RTKN gene in human bladder carcinoma tissues from Chinese patients.
Title: Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.
Title: Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma.
WI-14006 (e-PCR)
A005N24 (e-PCR)
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Physical Interaction
Evidence Code
Inferred from Direct Assay
Inferred from Electronic Annotation
Inferred from Electronic Annotation
Inferred from Direct Assay
Evidence Code
No biological Data available
Traceable Author Statement
Preferred Names
These reference sequences exist independently of genome builds.
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in
mRNA and Protein(s)
rhotekin isoform a
Status: REVIEWED
Description
Transcript Variant: This variant (1) encodes the longest isoform (a).
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
Conserved Domains (4)
Location:37 → 91
Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
Location:309 → 419
PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
Location:313 → 411
PH; PH domain
Location:117 → 270
A Cell division protein anillin
rhotekin isoform c
Status: REVIEWED
Description
Transcript Variant: This variant (3) differs in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
Conserved Domains (3)
Location:66 → 221
A Cell division protein anillin
Location:1 → 41
HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
Location:259 → 369
PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
rhotekin isoform b
Status: REVIEWED
Description
Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The encoded protein (isoform b) is shorter and has a distinct N-terminus, compared to isoform a.
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
Conserved Domains (4)
Location:23 → 78
Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
Location:296 → 406
PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
Location:300 → 398
PH; PH domain
Location:104 → 257
A Cell division protein anillin
The following sections contain reference sequences that belong to a
specific genome build.
Reference GRCh38.p7 Primary Assembly
NC_ Reference GRCh38.p7 Primary Assembly
441933 complement
mRNA and Protein(s)
Conserved Domains (4)
Location:23 → 78
Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
Location:296 → 406
PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
Location:300 → 398
PH; PH domain
Location:104 → 257
A Cell division protein anillin
Conserved Domains (3)
Location:37 → 91
Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
Location:116 → 271
A Cell division protein anillin
Location:309 → 419
PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
Conserved Domains (3)
Location:37 → 91
Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
Location:116 → 271
A Cell division protein anillin
Location:309 → 419
PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
RNA Sequence
RNA Sequence
RNA Sequence
RNA Sequence
Alternate CHM1_1.1
NC_ Alternate CHM1_1.1
598477 complement
Protein Accession
GenPept Link
UniProtKB Link
The following
resources are supplied by external providers. These providers are responsible for maintaining the links.
Interologous Interaction Database
Novus Biologicals
Pancreatic Expression Database
CREB Target Gene Database
Domain Mapping of Disease Mutations
GenScript:ORF Clones in your selected vector
GeneNetwork
Genevisible
GoPubMed Proteins
HuRef Browser
Human eFP Browser
Ingenuity Pathways Analysis
Kyoto Encyclopedia of Genes and Genomes
Nuclear Receptor Signaling Atlas (NURSA)
OrthoDB: The Hierarchical Catalog of Orthologs
PhosphoSitePlus
Protein Ontology Consortium
SeekQuence Research Antibodies
The Gene Wiki
The Weizmann Institute of Science GeneCards and MalaCards databases
iHOP - Information Hyperlinked over Proteins
iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
Addgene Non-profit plasmid repository
Creative Biomart
ExactAntigen/Labome
GeneCopoeia Inc.
Kazusa DNA Research Institute
LifeSpan BioSciences, Inc.
NITE Biological Resource Center
PlasmID Repository at Harvard Medical School
QIAGEN GeneGlobe
Sino Biological Inc.
antibodies-online
GeneWeaver
InterologFinder.org
Supplemental Content
Order cDNA clone
Related PubChem BioAssays
BioAssays related to the gene by protein target or RNAi target
Summarized PubChem Data on the gene, showing the active data by default
PubChem BioAssays done on the Gene target
BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record
BioAssays that contain the gene as the target of a RNAi reagent
BioProjects related to a gene
BioSystems
Link to CCDS
Related medical variations
Related CDD
Link from Gene to dbVar
Link to related EST entry
Full text in PubMedCentral identified from shared sequence links
Overlapping genes and two nearest non-overlapping genes on either side
Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types
Related Genome
Related GEO
Related HomoloGene
Link to related mapview entry
Link to related Nucleotide entry
Link to related OMIM entry
Related Probe entry
Link to related protein entry
PubChem Compounds
PubChem Substances
Link to related PubMed entry
Link to related PubMed article from GeneRIFs
Gene links to PubMed derived from omim_pubmed_cited links
Citations in PubMed identified from shared sequence and PMC links.
Link to Protein RefSeqs
Link to Nucleotide RefSeq RNAs
Related SNP records
SNPs linked from GeneView
Link to related taxonomy entry
Links to unigene
Related Variants
RTKN rhotekin [Homo sapiens]Gene ID:6242
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