I was blind, but I was ashamed of it if it was known. I refused to use a white stick and hated asking for help. After all, I was a teenager girl, and I couldn’t bear people to look at me and think I was not like them. I must have been a terrible danger on the roads, coming across me wandering through the traffic, motorists probably would have to step rapidly on their brakes. Apart from that, there were all sorts of disasters that used to occur on the way to and from work.One evening, I got off the bus about halfway home where I had to change buses, and as usual I ran into something,“I’m awfully sorry,”I said and stepped forward only to run into it again. When it happened a third time, I realized I had been apologizing to a lamppost. This was just one of the stupid things that constantly happened to me. So I carried on and found the bus stop, which was a request stop, where the bus wouldn’t stop unless passengers wanted to get on or off. No one else was there and I had to try to guess if the bus had arrived.Generally in this situation, because I hated showing I was blind by asking for help, I tried to guess at the sound. Sometimes I would stop a big lorry and stand there feeling stupid as it drew away. In the end, I usually managed to swallow my pride and ask someone at the stop for help.But on this particular evening no one j It seemed that everyone had suddenly decided not to travel by bus. Of course I heard plenty of buses pass, or I thought I did. But because I had given up stopping them for fear of making a fool of myself, I let them all go by. I stood there alone for half an hour without stopping one. Then I gave up. I decided to walk on to the next stop.小题1:The girl refused to ask for help because she thought_________.A．she might be recognizedB．asking for help looked sillyC．she was normal and independentD．being fond blind was embarrassing小题2:After the girl got off the bus that evening, she_________.A．began to runB．hit a person as usualC．hit a lamppost by accidentD．was caught by something小题3:At the request stop that evening, the girl___________.A．stopped a big lorryB．stopped the wrong busC．made no attempt to stop the busD．was not noticed by other people小题4:What was the problem with guessing at the sound to stop a bus?A．Other vehicles also stopped there. B．It was unreliable for making judgments. C．More lorries than buses responded to the girl. D．It took too much time for the girl to catch the bus.小题5:Finally the girl decided to walk to the next stop, hoping__________. A．to find people thereB．to find more buses thereC．to find the bus by herself thereD．to find people more helpful there - 跟谁学
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在线咨询下载客户端关注微信公众号&&&分类：I was blind, but I was ashamed of it if it was known. I refused to use a white stick and hated asking for help. After all, I was a teenager girl, and I couldn’t bear people to look at me and think I was not like them. I must have been a terrible danger on the roads, coming across me wandering through the traffic, motorists probably would have to step rapidly on their brakes. Apart from that, there were all sorts of disasters that used to occur on the way to and from work.One evening, I got off the bus about halfway home where I had to change buses, and as usual I ran into something,“I’m awfully sorry,”I said and stepped forward only to run into it again. When it happened a third time, I realized I had been apologizing to a lamppost. This was just one of the stupid things that constantly happened to me. So I carried on and found the bus stop, which was a request stop, where the bus wouldn’t stop unless passengers wanted to get on or off. No one else was there and I had to try to guess if the bus had arrived.Generally in this situation, because I hated showing I was blind by asking for help, I tried to guess at the sound. Sometimes I would stop a big lorry and stand there feeling stupid as it drew away. In the end, I usually managed to swallow my pride and ask someone at the stop for help.But on this particular evening no one j It seemed that everyone had suddenly decided not to travel by bus. Of course I heard plenty of buses pass, or I thought I did. But because I had given up stopping them for fear of making a fool of myself, I let them all go by. I stood there alone for half an hour without stopping one. Then I gave up. I decided to walk on to the next stop.小题1:The girl refused to ask for help because she thought_________.A．she might be recognizedB．asking for help looked sillyC．she was normal and independentD．being fond blind was embarrassing小题2:After the girl got off the bus that evening, she_________.A．began to runB．hit a person as usualC．hit a lamppost by accidentD．was caught by something小题3:At the request stop that evening, the girl___________.A．stopped a big lorryB．stopped the wrong busC．made no attempt to stop the busD．was not noticed by other people小题4:What was the problem with guessing at the sound to stop a bus?A．Other vehicles also stopped there. B．It was unreliable for making judgments. C．More lorries than buses responded to the girl. D．It took too much time for the girl to catch the bus.小题5:Finally the girl decided to walk to the next stop, hoping__________. A．to find people thereB．to find more buses thereC．to find the bus by herself thereD．to find people more helpful thereI was blind, but I was ashamed of it if it was known. I refused to use a white stick and hated asking for help. After all, I was a teenager girl, and I couldn’t bear people to look at me and think I was not like them. I must have been a terrible danger on the roads, coming across me wandering through the traffic, motorists probably would have to step rapidly on their brakes. Apart from that, there were all sorts of disasters that used to occur on the way to and from work.One evening, I got off the bus about halfway home where I had to change buses, and as usual I ran into something,“I’m awfully sorry,”I said and stepped forward only to run into it again. When it happened a third time, I realized I had been apologizing to a lamppost. This was just one of the stupid things that constantly happened to me. So I carried on and found the bus stop, which was a request stop, where the bus wouldn’t stop unless passengers wanted to get on or off. No one else was there and I had to try to guess if the bus had arrived.Generally in this situation, because I hated showing I was blind by asking for help, I tried to guess at the sound. Sometimes I would stop a big lorry and stand there feeling stupid as it drew away. In the end, I usually managed to swallow my pride and ask someone at the stop for help.But on this particular evening no one j It seemed that everyone had suddenly decided not to travel by bus. Of course I heard plenty of buses pass, or I thought I did. But because I had given up stopping them for fear of making a fool of myself, I let them all go by. I stood there alone for half an hour without stopping one. Then I gave up. I decided to walk on to the next stop.小题1:The girl refused to ask for help because she thought_________.A．she might be recognizedB．asking for help looked sillyC．she was normal and independentD．being fond blind was embarrassing小题2:After the girl got off the bus that evening, she_________.A．began to runB．hit a person as usualC．hit a lamppost by accidentD．was caught by something小题3:At the request stop that evening, the girl___________.A．stopped a big lorryB．stopped the wrong busC．made no attempt to stop the busD．was not noticed by other people小题4:What was the problem with guessing at the sound to stop a bus?A．Other vehicles also stopped there. B．It was unreliable for making judgments. C．More lorries than buses responded to the girl. D．It took too much time for the girl to catch the bus.小题5:Finally the girl decided to walk to the next stop, hoping__________. A．to find people thereB．to find more buses thereC．to find the bus by herself thereD．to find people more helpful there科目:难易度:最佳答案小题1:D小题2:C小题3:C小题4:B小题5:A解析
知识点:&&基础试题拔高试题热门知识点最新试题
关注我们官方微信关于跟谁学服务支持帮助中心The 2-year-old who threw a tantrum in front of the president: She was my kid.
Remember the Toddler Who Threw a Tantrum in Front of President Obama? That Was My Kid.
Remember the Toddler Who Threw a Tantrum in Front of President Obama? That Was My Kid.
President Barack Obama and First Lady Michelle Obama talk with guests, including Arun Chaudhary, Laura Moser and their children Leo and Claudia, in the Red Room prior to hosting a Passover Seder dinner in the Old Family Dining Room of the White House, April 3, 2015.
Photo courtesy Pete Souza/The White House
President Barack Obama and first lady Michelle Obama talk with guests in the Red Room prior to hosting a Passover Seder dinner in the White House, April 3, 2015.
Pete Souza/White House
My 2-year-old daughter Claudia cannot articulate r&s or l&s properly and falls asleep sucking on the ear of a putrid stuffed sheep. She&s usually easygoing by toddler standards, except in the mornings when she demands to strip off all her clothes and don nothing but a fitted dinosaur sheet. (&It&s not a sheet!& she screams. &It&s a sheet-dress! I wear my sheet-dress!&) Somehow, over the course of a few strange days last spring, this unassuming little person became the star of the Internet news cycle.
It was precisely her determination to transform inappropriate household items (not just fitted sheets but also dishrags, washcloths, even Chinese-takeout napkins) into eveningwear that rocketed Claudia to Internet fame. It was early April, and we had for once negotiated her into a dress-dress and escorted her to the White House to have her picture taken with the president before the annual Passover Seder that he has held since his first year in office.
In her fury, Claudia threw herself at the feet of the most famous man in the world.
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Claudia, thoroughgoing 2-year old that she is, had no interest in this ritual. She didn&t want to be in the White House, whatever that was. She wanted to be in her bedroom, emptying out the drawers of her changing table in search of more sheets.
&I take off my shoes,& she told me.
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&No, sweetie, not right now.&
&I take off my dress,& she suggested next.
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&Claudia, if you could just wait one second&&
&I wear a sheet-dress.&
&I&m so sorry, sweet girl, but we didn&t bring any sheets tonight!&
My lack of preparation outraged her. That same instant, the hush associated with the entrance of the chief executive fell over the Red Room, but Claudia didn&t care. Claudia wanted a sheet, and she wanted one now. In her fury, she threw herself at the feet of the most famous man in the world. That same instant, Pete Souza, the chief official White House photographer, walked into the room.
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I will say that I have met the president before. My husband was among the handful of campaign staffers who held an impromptu Seder in a conference room of a Harrisburg, Pennsylvania, Sheraton during the 2008 Pennsylvania primary. I have attended these Seders every year since I was pregnant with my now&6-year-old son. Also, not unimportantly, I follow the news, and like many news-following Americans I am sufficiently aware of Obama&s temperament to know that he&s not going to expend much energy judging the 2-year old at his feet or, for that matter, her parents. The explosion ended, my father (brought here for that express purpose) whisked Claudia and her brother off, and that was that. We thought no more of the tantrum until almost two months later when the White House photo office emailed me a photograph of the incident &for personal use only.&&&&&&&&&
The photograph was wonderful, obviously, but it didn&t for an instant occur to me that it would interest anyone beyond my circle of family and friends when I posted it on my Facebook page, as I do with every year&s Seder pictures. I then went off to the grocery store&my usual Thursday afternoon ritual. While I was there, my brother tweeted the photo, saying, &This really might be the best picture ever: my niece Claudia throwing a fit at Passover.&
This really might be the best picture ever: my niece Claudia throwing a fit at Passover. & Benjamin Moser (@BenjaminFMoser)
By the time I returned with dinner, Claudia&s tantrum was all over the Internet. Entirely unrelated celebrities (Judd Apatow, Joyce Carol Oates) had retweeted my brother. By dinnertime, the picture was on the top of the Reddit home page, with 1 million views.
Over the course of the weekend Claudia&s tantrum was featured in Salon, the Daily Mail, the Huffington Post, CNN, the Washington Post, Yahoo Parenting (FYI, those moms are angry), the Telegraph, the New York Daily News, Time&I could go on. She was written about in Macedonia, China (and Taiwan), Argentina, New Zealand, Peru. Saturday morning, while shepherding my kids to a birthday party, I answered the phone from an unknown 212 it was Good Morning America. I declined to bring Claudia on the show, but they still ran multiple segments about her. She was on Sky News and the Today Show and the local station in the small French town where my brother was staying. And everywhere, everyone had a lot to say about Claudia.
I was shocked by what Internet commenters read into the picture.
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I&m mostly disciplined enough to avoid the comments section of pieces I& what good can come of reading about how annoying/glib/uninformed I am? But with the Claudia picture, I couldn&t resist the comments, precisely because they seemed so completely disconnected from reality. Most people&the ones who&ve actually raised kids&were amused and sympathetic. They understood that my 2-year-old doesn&t care if the president of the United States has just entered the room. This contingent offered the same dorkily good-natured ripostes over and over again: &Guess she voted Republican?& and &So this is what it&s like dealing with John Boehner!& The Jews liked to joke that someone else had found the Afikomen.
But if the Internet has taught us anything, it&s that crazy people have a great deal of free time on their hands. And I was shocked by what they read into the picture. They saw my political beliefs and the pride I took in my inability to raise a child. (&The &she&s just a kid& excuses are the excuses liberal parents make for their lack of parenting skills.&) They saw my income and my ethnic background: I was a &wealthy Jewish donor&&don&t I wish!&and my daughter a spoiled brat: &She doesn&t act like the sort of child that has ever heard the word &No& let alone felt anything other than expensive clothes on her backside.& One commenter recommended thyroid medication to bring my daughter back in balance, but no one said a word about fitted sheets.
Perhaps these hecklers would&ve been satisfied if my face, in that split-second captured by the photographer, had conveyed more dismay, or I&d been in some way publicly chastised? Or maybe the president should&ve taken charge of the situation. I mean, he&s supposed to be a leader, right? &The kid has obviously used this to get her way before,& observed one Daily Mail reader. &Maybe POTUS should paddle her butt!& He was among many who endorsed beating the crap out of my child.
And speaking of Obama&I already knew, of course, that Obama, like any other president, has his professional haters. But Obama doesn&t have to be speaking out against gun violence or praising equal pay for women to provoke his opponents& just standing calmly above a distraught toddler is sufficient. Many commenters opined that Claudia was upset about the president&s reckless tax-and-spend ways (&She just learned that her FOOD STAMPS are going to be cut by 10%,& &She knows she won&t have Social Security,& &Obama took her Binky and gave it to someone he deemed more entitled to it,& etc.) and/or the First Lady&s healthy-eating initiatives (&The little girl thought she would be eating food from the First Diva&s school lunch program&). This cohort scorned me but felt sympathy for my daughter, because after all, who&wouldn&t&throw a tantrum in the presence of the &Prince of Darkness&? In short: &Only a truly innocent child can say what the entire World thinks of Obama & get away with it!&
As I pored over the comments, I was reminded that Internet stars are less humans than tropes: of heroism (black cop helping white racist) and villainy (Minnesota dentist posing next to Cecil the Lion) and everything in between. Actual living humans&in this case, my baby girl&are reduced to Grumpy Cat memes as every day the Internet offers up new canvasses where other people can project their fears and loathings. For almost an entire week, my daughter provided this grist.
For the meme herself, the most significant outcome of her brush with the big time may have been that, on Memorial Day morning, three days after my brother&s tweet, she woke up and announced that she was done with diapers. It was as if, as an international Internet celebrity, she suddenly felt compelled to up her game. And that was news I could use.Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in... - Abstract - Europe PMC
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(PMID:9037538)
Veterans Affair Medical Center, University of Washington, Seattle 98108, USA. szot@u.washington.edu
[-2):233-245]
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
10.-328X(96)00184-2
Two models of genetically epilepsy-prone rat (GEPR) exist, the GEPR-3 and GEPR-9, GEPR-3 and GEPR-9 share a deficiency in presynaptic norepinephrine (NE) and serotonin (5HT) content in specific regions of the central nervous system (CNS). The presynaptic content of dopamine (DA) does not appear to be altered in either adult GEPR strain compared to Sprague-Dawley (SD) rats, the strain from which the GEPR was derived. Presynaptic content of monoamine neurotransmitters, such as NE, 5HT and DA, are maintained by several regulatory proteins which include: synthesis, re-uptake, release, degradation and vesicular transport. To further characterize the monoamine deficiency observed in the GEPR, the mRNA level of the rate limiting enzymes for the synthesis of NE, 5HT and DA and each of the neurotransporter proteins were measured in seizure-naive GEPR-3, GEPR-9 and SD rats. In the locus coeruleus (LC), the major noradrenergic locus, tyrosine hydroxylase (TH) mRNA level was significantly reduced only in GEPR-9 animals compared to SD rats and GEPR-3, while NE transporter (NET) mRNA was significantly elevated in GEPR-3 compared to SD rats and GEPR-9. TH and DA transporter (DAT) mRNA was measured in the dopaminergic neurons of the substantia nigra pars compacta (SNpc), ventral tegmental area (VTA) and zona incerta (ZI), DAT mRNA level was significantly reduced in all dopaminergic neurons in the GEPR-3 compared to SD rats and GEPR-9, while TH mRNA level was significantly elevated in the SNpc/VTA equally in GEPR-3 and GEPR-9 compared to SD rats. In the ZI, TH mRNA level was significantly reduced in GEPR-3 compared to SD rats and GEPR-9. In the dorsal raphe (DR), a major serotonergic locus, tryptophan hydroxylase (TRH) mRNA level was not significantly different from SD in either strain of GEPR; however, 5HT transporter (SERT) mRNA level was significantly reduced in GEPR-9 in the dorsal and lateral regions of the DR compared in SD rats and GEPR-3. These data indicate that two of the regulatory systems that maintain NE, 5HT and DA content are altered in a differential manner in seizure-naive GEPR-3 compared to seizure-naive GEPR-9, with GEPR-3 showing more alterations in dopaminergic neurons. It is uncertain at the present time how these alterations in mRNA level relate to the enhanced seizure susceptibility of these animals. It was apparent that a straightforward correlation between neurotransmitter loss to transcriptional changes in synthesizing enzymes mRNA or to re-uptake protein mRNA was not observed in noradrenergic and serotonergic neurons. Therefore, the decrease in presynaptic NE and 5HT tissue content in these animals may be due to posttranscriptional modification. In contrast, presynaptic DA tissue content which was unaltered in both strains of GEPR, shows an alteration in TH and DAT mRNA level compared to SD rats in all dopaminergic neurons examined. This indicates a possible involvement of DA in regulating the seizure susceptibility of these animals.
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