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Manuel Varela1,*, Carmen Rodriguez1, Luis Vigil1, Eva Cirugeda2, Ana Colas1 andBorja Vargas1DOI:&10.07.12182
Journal of Diabetes pages 287&293, Author Information1Department of Internal Medicine, University Hospital of Mostoles, Madrid, Spain2Computer Science Department (DISCA), Polytechnic University of Valencia, Alcoi, Spain*
Correspondence Manuel Varela, Department of Internal Medicine, University Hospital of Mostoles, c/ rio Jucar s/n, Mostoles, Madrid 28935, Spain. Tel: +34 91 6648729 Fax: +34 91 6648087 Email:
Publication HistoryIssue published online: 28 JAN 2015Article first published online: 19 AUG 2014Accepted manuscript online: 9 JUN AM ESTManuscript Accepted: 1 JUN 2014Manuscript Received: 3 MAR 2014
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metabolic syndrome X;type 2 diabetes mellitus关键&#x8：血糖，X代谢&#x7合征，2型糖尿病AbstractBackgroundOne of the earliest signs of dysfunction in a complex system is the simplification of its output. A well-accepted method to measure this phenomenon is detrended fluctuation analysis (DFA). Herein, we evaluated the usefulness of DFA at the threshold of type 2 diabetes mellitus (T2DM).MethodsWe report on the clinical and glucometric characteristics of a sample of 103 patients at increased risk of developing T2DM. All patients had HbA1c levels 5%&6.4% and met at least one of the following criteria: body mass index (BMI)&&&30&kg/m2, essential hypertension or a first-degree relative with T2DM. For each patient, a 24-h glucose time series was obtained, and the clinical and glucometric variables were compared.ResultsThere was a significant correlation between the number of National Cholesterol Education Program & Adult Treatment Panel (ATP III) metabolic syndrome (MS)-defining criteria and DFA (&&=&0.231, P&=&0.019), and DFA differed significantly between patients meeting or not the ATP III definition of MS (1.443 vs 1.399, P&=&0.018). The DFA was not correlated with HbA1c. Depending on how it was calculated, the area under the log(Fn)&log(n) curve correlated with HbA1c levels or the number of MS criteria. Conventional variability metrics (mean amplitude of glycemic excursions) did not differ between patients complying or not with the definition of MS.ConclusionsComplexity analysis is capable of detecting differences in variables related to the risk of developing T2DM and could be a useful tool to study the initial phases of glucoregulatory dysfunction leading to T2DM.摘要&#x80景：一个复杂的&#x7&#x7发生功&#x80障碍的最早征象之一就是它的产&#x51下降了。非趋&#x52波动分析（detrended fluctuation analysis，DFA）是一&#x79&#x88广为接受的测&#x91这一现象的方法。在这&#x91，我&#x4评估了DFA在2型糖尿病阈值中的实用性。方法：我&#x4研究的样本为103名&#x53&#x80发展为2型糖尿病的高&#x98险患者，报告了他&#x4的临床与血糖测&#x91特征。所有患者的HbA1c水平为5%&6.4%并且符合下列标准中的至少一条：体&#x91指数（BMI）&30&kg/m2、原发性高血压或者有1名一级亲属有2型糖尿病。测&#x91&#x6一名患者的24 h时间序列血糖值，比较他&#x4的临床以&#x53血糖测&#x91值变&#x91。结果：全美胆&#x56醇教育计划&成&#x4&#x6疗小组（ATP III）定义的代谢&#x7合征的&#x8&#x65标准的数&#x91与DFA结果显著相关（&&=&0.231，P&=&0.019），符合或者不符合ATP III代谢&#x7合征定义的患者之间的DFA结果有显著性&#x5异（分别为1.443与1.399；P&=&0.018）。DFA结果与HbA1c之间没有相关性。根据不同的计算方式，log(Fn)-log(n)曲&#x7下面&#x79与HbA1c水平或MS&#x8&#x65标准的数&#x91相关。在符合或者不符合MS定义的患者之间常规的变异性指标（平均血糖波动幅度）没有&#x5异。结&#x8：复杂性分析&#x53以鉴别有&#x53&#x80&#x5致2型糖尿病&#x98险的各&#x79变&#x91之间的&#x5异，对于研究&#x5致2型糖尿病的早期相血糖调节功&#x80障碍来说&#x53&#x80是一&#x79有用的工具。在改革开放的初期,人们都很乐观(at the threshold of)_作业帮
拍照搜题，秒出答案
在改革开放的初期,人们都很乐观(at the threshold of)
在改革开放的初期,人们都很乐观(at the threshold of)
那个后边的英文可以翻译为：“在门槛”